One‐Pot and Gram‐Scale Synthesis of Fe‐Based Nanozymes with Tunable O2 Activation Pathway and Specificity Between Associated Enzymatic Reactions DOI
Yuwei Qiu, Tianqi Cheng, Bo Yuan

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract Nanozymes have recently gained attention for their low cost and high stability. However, unlike natural enzymes, they often exhibit multiple enzyme‐like activities, complicating use in selective bioassays. Since H 2 O are common substrates these reactions, controlling activation—and thus reaction specificity—is crucial. Recent advances tuning the chemical state of cerium enabled control over activation pathways tunable peroxidase/haloperoxidase‐like activities. In contrast, on an element oxidase/laccase nanozymes impact its activities remains unexplored. Herein, a facile one‐pot method is presented gram‐scale synthesis Fe‐based with compositions Fe 3 4 C by adjusting preparation temperatures. The ‐containing samples superior laccase‐like activity, while C‐containing counterparts demonstrate better oxidase‐like activity. This divergent behavior linked to surface species: abundant reactive 2+ promotes activity via 3+ ‐superoxo formation, whereas metallic facilitates OH radical generation Controlled improved sensitivity corresponding biomolecule detection, which should inform design enhanced specificity.

Language: Английский

Sensitive lateral flow immunoassay enabled by signal amplification strategy with high active oxidase-like nanozymes DOI
Jie Zhu, Yunhui Cheng, Xufeng Wang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106470 - 106470

Published: March 1, 2025

Language: Английский

Citations

0
Enhancing the Reactivity of Nanozymes by Asymmetric Structural Oxygen Vacancy Electron Transfer for Colorimetric Sensing and TAC Analysis DOI

Lishi Chen,

Pingfei Wang,

Ao Yin

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

By regulating the electron density of atoms within reaction active center, catalytic activity nanozymes can be precisely controlled, thereby enhancing their reactivity and sensitivity in applications such as colorimetric sensing. In this study, we synthesized metal oxide Fe-MMOov nanozymes, enriched with doping defects oxygen vacancy defects, by Fe-doped LDH an ultrathin 2D structure through roasting-induced topological transformation. This process tunes distribution center its intrinsic asymmetric Zn-Ov-Fe structure, resulting excellent POD-like OXD-like multienzyme activities. enhancement contributes to overall effectiveness colorimetry. These improvements facilitated successful application total antioxidant capacity (TAC) detection various fruit juices commercial beverages. Density functional theory (DFT) calculations revealed that d-band Fe is enhanced Ov microenvironment nanozyme, leading improved activity. Based on this, a Fe-MMOov/TMB visual system was established successfully validated for analytes ascorbic acid, cysteine, glutathione. It further integrated mobile platform on-site TAC food samples. study introduces approach nanozyme design sensing while also presenting rapid, cost-effective, dependable strategy miniaturization, convenience, widespread applicability detection. We demonstrate how introduction vacancies into enhances activity, paving way development more efficient catalysts

Language: Английский

Citations

0
Targeted reversal of iron deposition by highly active manganese-doped carbon dots in MRI-guided treatment of Parkinson's disease DOI
Huihui Wang, Maolin Zhang,

Dongchuan Chu

et al.

Carbon, Journal Year: 2025, Volume and Issue: unknown, P. 120152 - 120152

Published: Feb. 1, 2025

Language: Английский

Citations

0
Boosting Peroxidase-Mimetic Activity of FeMn-NCe Dual-Atom Radiosensitizing Nanozymes for Augmented Radiodynamic Immunotherapy DOI
Bo Chen, Yinggang Wang,

Min Mu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Dual-atom nanozymes (DAzymes) have garnered considerable attention as catalysts for reactive oxygen species (ROS)-based therapies, effectively leveraging ROS generation within the tumor microenvironment (TME). Herein, we introduce FeMn-NCe DAzymes, which are meticulously engineered enhanced peroxidase (POD)-mimetic activity and potent radiosensitization to advance radioimmunotherapy. Density functional theory (DFT) calculations reveal that DAzymes lower energy barrier increase substrate affinity, enabling highly efficient catalytic performance. Within TME, these efficiently convert overexpressed hydrogen peroxide (H2O2) into hydroxyl radicals (•OH), potentially activating cGAS-STING immune pathway. This POD-mimetic catalysis is further accelerated under X-ray irradiation, significantly enhancing radiosensitization. Additionally, a uniform coating of ultrasmall gold nanoparticles on enhances absorption cancer cells. The incorporation STING agonist diABZI onto induces long-term antitumor immunity, reprograms immunosuppressive suppresses growth metastasis following single low-dose treatment. work highlights valuable strategy designing radiodynamic immunotherapy.

Language: Английский

Citations

0
Peripheral effect promotes single-atom catalysis DOI

Yicong Chai,

Fenfei Wei,

Liru Cao

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 536, P. 216649 - 216649

Published: April 6, 2025

Language: Английский

Citations

0
Revealing Significant Electronic Effects on the Oxygen Reduction Reaction with Iron Porphyrins DOI
Haonan Qin, Jiafan Kong,

Xinyang Peng

et al.

ChemSusChem, Journal Year: 2024, Volume and Issue: 18(3)

Published: Aug. 30, 2024

Understanding electronic effects on catalysis from a mechanism point of view is fundamental significance but also challenging. We herein report the oxygen reduction reaction (ORR) with Fe porphyrins. By using FeIII tetraphenylporphyrin (TPP-Fe) and tetra(pentafluorophenyl)porphyrin (TPFP-Fe), we showed their different electrochemical chemical behaviors for ORR. Mechanism studies revealed that FeIII-superoxo species TPP-Fe can undergo smooth protonation trifluoroacetic acid (TFA) electron-deficient TPFP-Fe cannot be protonated TFA. The reactivity difference between origin catalytic ORR behaviors.

Language: Английский

Citations

3
A Novel “Three‐in‐One” Copper‐Based Metal‐Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy DOI Creative Commons
Shuohui Dong,

Haolin Cao,

Ye Yuan

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Despite considerable advancements in the treatment of colorectal cancer (CRC), overall survival rate for patients with advanced CRC remains below 50%, primarily due to challenges posed by drug resistance and metastasis. Here, a novel “Three‐in‐One” Cu‐based metal‐organic framework nanozyme peroxidase‐like (POD‐like) activity has been successfully developed, aiming promote cell death dual targeting oxidative stress copper ion homeostasis, which could via apoptosis cuproptosis, facilitate hypoxia‐inducible factor 1α (HIF‐1α) degradation, leading reversal chemoresistance tumor therapy. These nanozymes, composed 2‐propylimidazole (Cu‐PrIm), feature distorted Cu‐N4 catalytic active center that mimics natural enzyme structures consisting histidine residues, endowing them enzyme‐like activities. The antitumor efficacy Cu‐PrIm nanozymes is validated various vivo models CRC. Especially exhibit excellent biocompatibility, biodegradability, tolerable toxicity profile mouse models, making strong candidate clinical translation. Taken together, study introduces therapeutic paradigm these vulnerabilities leveraging potential using address multiple pathways simultaneously.

Language: Английский

Citations

2
Recent advances toward emerging nanozymes with aggregation-induced emission DOI Creative Commons
Xin Li, Zhao Wang, Jing He

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

AIE luminogens (AIEgens) are a class of unique fluorescent molecules that exhibit significantly enhanced luminescence properties and excellent photostability in the aggregated state. Recently, it has been found some AIEgens can produce reactive oxygen species, which means they may have potential enzyme-like activities thus termed "AIEzymes". Consequently, discovery design novel with emerged as new exciting research direction. Additionally, enhance catalytic efficiency traditional nanozymes by direct combination, thereby endowing multifunctionality. In this regard, aggregation-induced emission (AIE) properties, represents win-win integration, not only take full advantage low cost stability nanozymes, but also incorporate biocompatibility fluorescence AIEgens. These synergistic compounds bring about opportunities for various applications, making AIEzymes interest biomedical research, food analysis, environmental monitoring, especially imaging-guided diagnostics. This review will provide an overview latest strategies achievements rational preparation AIEzymes, well current trends, future challenges prospective solutions. We expect work encourage motivate more people to study explore further promote their applications fields.

Language: Английский

Citations

1
One‐Pot and Gram‐Scale Synthesis of Fe‐Based Nanozymes with Tunable O2 Activation Pathway and Specificity Between Associated Enzymatic Reactions DOI
Yuwei Qiu, Tianqi Cheng, Bo Yuan

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract Nanozymes have recently gained attention for their low cost and high stability. However, unlike natural enzymes, they often exhibit multiple enzyme‐like activities, complicating use in selective bioassays. Since H 2 O are common substrates these reactions, controlling activation—and thus reaction specificity—is crucial. Recent advances tuning the chemical state of cerium enabled control over activation pathways tunable peroxidase/haloperoxidase‐like activities. In contrast, on an element oxidase/laccase nanozymes impact its activities remains unexplored. Herein, a facile one‐pot method is presented gram‐scale synthesis Fe‐based with compositions Fe 3 4 C by adjusting preparation temperatures. The ‐containing samples superior laccase‐like activity, while C‐containing counterparts demonstrate better oxidase‐like activity. This divergent behavior linked to surface species: abundant reactive 2+ promotes activity via 3+ ‐superoxo formation, whereas metallic facilitates OH radical generation Controlled improved sensitivity corresponding biomolecule detection, which should inform design enhanced specificity.

Language: Английский

Citations

0