Assembly of Biaryl Amines via Mild Copper-Catalyzed Coupling of Anilines with (Hetero)aryl Chlorides/Bromides

Organic Letters, Journal Year: 2025, Volume and Issue: 27(6), P. 1498 - 1503

Published: Jan. 31, 2025

CuI/6-hydroxy picolinohydrazide-catalyzed coupling of (hetero)aryl chlorides with anilines proceeded well at 100 °C to afford biaryl amines in a diverse manner, which represents the first example Cu-catalyzed under milder conditions. The same catalytic system could make bromides work room temperature, giving corresponding products an excellent reaction scope.

Language: Английский

Room-Temperature Copper Cross-Coupling Reactions of Anilines with Aryl Bromides

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 28, 2025

We present a novel copper-catalyzed method for aniline cross-couplings promoted by 6-hydroxy picolinhydrazide ligand. The achieves room-temperature reactivity with aryl bromides, enabled methanol/ethanol solvent mixture and mild, functional group-compatible base, catalyst loadings as low 0.5 mol %. use of industrially preferred solvents well the high catalytic activity, offers significant advancement in practicality scalability industrial processes. Furthermore, approach extends to cross-coupling chlorides under elevated temperatures demonstrates compatibility additional nucleophile classes.

Language: Английский