Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Abstract The clinical translation of metal‐based peroxidase‐like nanozymes for antitumor therapy faces two critical challenges: off‐target catalytic activation and suboptimal hydroxyl radical (•OH) generation efficiency. To address these limitations, an innovative chainmail nanocatalyst featuring nitrogen‐doped carbon‐encapsulated nanoceria is developed, which combines spatial confinement effects with photo‐trigger enhancement. graphitic carbon shell serves as a physical barrier that effectively isolates metallic cerium from the biological environment, reducing nonspecific by 100% compared to bare nanoceria. Remarkably, under 1064 nm laser irradiation, electrons species can penetrate through quantum tunneling effects, activating multiple enzymatic pathways. Vacancy engineering further optimizes Ce 3+ /Ce 4+ redox pair ratio (1.75 vs 0.44 in pristine nanoceria), establishing electron reservoir facilitates amplification H 2 O ‐to‐•OH conversion glutathione oxidase‐mimicking activity tumor microenvironment remodeling. This dual mechanism synergistically elevates intracellular oxidative stress while preserving normal tissue viability. In vivo evaluations demonstrate photoactivated exhibits remarkable suppression efficacy, prolonging survival duration tumor‐bearing mice 33 days 70 days. light‐gated architecture provides paradigm spatiotemporally controlled therapy, resolving dilemma between potency specificity nanozyme design.

Language: Английский