Boosting Tumor Apoptosis and Ferroptosis with Multienzyme Mimetic Au Single‐Atom Nanozymes Engaged in Cascade Catalysis DOI
Ziyi Wang,

Runan Chen,

Wenying Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Abstract Nanozyme‐based catalytic therapy has garnered much attention in cancer treatment for converting endogenous substrates into reactive oxygen species (ROS), which induce oxidative stress damage tumors. However, the effectiveness of nanozymes is hindered by limited availability these tumor microenvironment. To address this, a novel gold‐based single‐atom nanozyme (AuSAN), glucose oxidase (GOx, G), and lactate (LOx, L) are meticulously engineered highly ordered biomimetic composite M/GLB@AuSAN, forming an interconnected cascade catalysis that catalyzes carbon sources ROS as sustained antitumor strategy. The loaded GOx LOx aerobically catalyze to produce H 2 O , then rapidly converted ·OH, •− AuSAN. generated serves positive feedback substrate further GOx‐ LOx‐mediated aerobic catalysis, significantly amplifying thereby enhancing accumulation. abundant intracellular scarce effectively exacerbate protein phosphorylation, lipid peroxidation, mitochondrial damage, ultimately provoking apoptosis ferroptosis vitro vivo. Therefore, integrated design GOx/LOx/AuSAN provides promising strategy combine multiple enzymatic activities, deplete sources, enhance production, resulting suppression melanoma progression.

Language: Английский

Closed-loop cascade nanozyme strategy for mutually reinforced catalytic and mild-temperature photothermal therapeutic effects DOI Creative Commons
Fan Yang,

Chunyu Yan,

Nannan Li

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 4, 2025

Nanocatalysis coupled with photothermal therapy is a potent anti-cancer approach, yet its clinical utility limited by low concentration of tumor substrate, redox interference, and risks overheating normal tissues. Herein, we propose an innovative closed-loop nanozyme approach that leverages the synergistic effects catalytic mild (mPTT) to address aforementioned challenges. The strategy features folic acid-functionalized iron single-atom catalyst (FeNC-FA), designed exhibit exceptional multienzymatic capabilities optimal response. In system, engineered FeNC-FA capable inducing reactive oxygen species (ROS) storm depleting glutathione (GSH) in specific microenvironment (TME) initiate ferroptosis. Concurrently, accumulation ROS effectively cleaves heat shock proteins (HSPs), thereby enhancing mPTT. An intriguing aspect increased temperature within TME further facilitates conversion H2O2 O2, alleviating hypoxia providing positive feedback circuit boost therapy. Additionally, advanced photoacoustic (PA) imaging allow for self-monitoring their at sites, guiding mPTT process. Taken together, it provides PA image-guided, mutually reinforced both vitro vivo. This targeted holds great promise personalized medicine applications.

Language: Английский

Citations

0
Catalytic mechanism and biomedical applications of diatomic nanozymes DOI Open Access
Xiaonan Wang,

Lingjie Hou,

Mengyu Dang

et al.

Microstructures, Journal Year: 2025, Volume and Issue: 5(3)

Published: April 21, 2025

The diatomic nanozymes (DANs) represent a class of nanomaterials containing dual metals as active centers with enzyme-like activity inspired by natural enzymes. They hold unique catalytic properties caused their dual-atom structure, which have attracted significant attention. mechanism DANs may involve synergistic interactions between neighboring metal atoms and the regulation electron arrangement near center, enhancing specificity. excellent exceptional stability make promising candidates for developing sensitive biosensors capable precisely detecting disease markers. Furthermore, show great promise antitumor therapeutic agents, offering enhanced efficacy while minimizing side effects. This review outlines biomedical applications DANs. discussion section highlights challenges prospects in development DANs, insights future research endeavors this field.

Language: Английский

Citations

0
Synergizing Catalysis with Post-catalysis Pseudo-Iron Release by Building Dynamic Catalytic Active Sites in Diatomic Nanozymes for Boosting Cancer Therapy DOI

Songjing Zhong,

Zeyu Zhang, Zhuo Wang

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
Amorphous RuO2 Nanozymes with an Excellent Catalytic Efficiency Superior to Natural Peroxidases DOI
Zirui Qin, Lei Jiao, Lijun Hu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract Developing efficient peroxidase‐like nanozymes to surpass natural enzymes remains a significant challenge. Herein, an amorphous RuO 2 nanozyme with activity is synthesized for activating H O specific of 1492.52 U mg −1 , outperforming the crystalline by factor 22 and far superior peroxidases. Amorphous long‐range disordered atomic arrangements can effectively elongate O─O bonds in . Abundant oxygen vacancies lead upshift d ‐band center, enhancing exceptional adsorption strength which improve electron transfer efficiency ensure activity. Accordingly, nanozyme‐linked immunosorbent assay developed precise sensitive detection prostate‐specific antigens limit as low 0.52 pg mL This study introduces simple approach developing high‐performance analytical performances clinical diagnostics.

Language: Английский

Citations

0
Boosting Tumor Apoptosis and Ferroptosis with Multienzyme Mimetic Au Single‐Atom Nanozymes Engaged in Cascade Catalysis DOI
Ziyi Wang,

Runan Chen,

Wenying Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Abstract Nanozyme‐based catalytic therapy has garnered much attention in cancer treatment for converting endogenous substrates into reactive oxygen species (ROS), which induce oxidative stress damage tumors. However, the effectiveness of nanozymes is hindered by limited availability these tumor microenvironment. To address this, a novel gold‐based single‐atom nanozyme (AuSAN), glucose oxidase (GOx, G), and lactate (LOx, L) are meticulously engineered highly ordered biomimetic composite M/GLB@AuSAN, forming an interconnected cascade catalysis that catalyzes carbon sources ROS as sustained antitumor strategy. The loaded GOx LOx aerobically catalyze to produce H 2 O , then rapidly converted ·OH, •− AuSAN. generated serves positive feedback substrate further GOx‐ LOx‐mediated aerobic catalysis, significantly amplifying thereby enhancing accumulation. abundant intracellular scarce effectively exacerbate protein phosphorylation, lipid peroxidation, mitochondrial damage, ultimately provoking apoptosis ferroptosis vitro vivo. Therefore, integrated design GOx/LOx/AuSAN provides promising strategy combine multiple enzymatic activities, deplete sources, enhance production, resulting suppression melanoma progression.

Language: Английский

Citations

2