Optimizing locally delivered periodontitis therapy: Development of chitosan‐hydroxyapatite‐encapsulated drug via electrospraying DOI
Binpeng Zhang,

Shaofu Yan,

Yao Zhang

et al.

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Abstract This study presents the development of an optimized drug delivery system for periodontitis treatment utilizing chitosan‐hydroxyapatite nanoparticles. Employing electrospraying technique, researchers encapsulated antibiotic amoxicillin within composite matrices while varying concentrations chitosan and hydroxyapatite The resulting microparticles displayed sizes ranging from 276 to 386 μm. Characterization produced encapsulations indicated that higher resulted in formation larger particles with rougher surfaces, increased mechanical strength, enhanced thermal stability. Notably, nanoindentation analysis revealed increase hardness 0.21 0.35 GPa, elastic modulus 5.32 8.72 GPa escalating content, meeting or surpassing requirements load‐bearing regenerative biomaterials. In vitro release assessments exhibited sustained over 24 h, predominantly through diffusion dissolution mechanisms. Formulations lower polymer mineral content showcased elevated rates, F1 encapsulation (0.5% chitosan, 0.2% HAP) achieving a cumulative 78.3 ± 3.2% contrast 65.1 2.7% F5 formulation (2.5% 1% HAP). These selectively modulated overproduction proinflammatory cytokines, including IL‐1β, IL‐6, TNF‐α, gingival fibroblasts osteoblasts without compromising cell viability. An artificial neural network (ANN) model accurately forecasted material properties biological performance formulations based on their compositional variations, yielding correlation coefficients exceeding 0.97. computational platform offers virtual screening tool refining therapies. developed microparticulate demonstrates promising potential prolonged controlled delivery, improved properties, targeted regulation inflammatory response.

Language: Английский

Research Progress of Natural Polymer Materials in Bone Defect Repair DOI

滕超 奉

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 907 - 914

Published: Jan. 1, 2025

Language: Английский

Citations

0
Electrospun nanofibers and their potential in dental applications: an updated review DOI Open Access

Fernando Rosas López Portillo,

Aurea Elizabeth Valle Urias,

Tonantzin González Arredondo

et al.

International Surgery Journal, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

The use of Electrospun nanofibers has proven to be an innovative technology with great potential in the field dentistry, particularly tissue engineering and regeneration oral dental tissues. Their ability mimic extracellular matrix facilitates cell adhesion, nutrient transport, proliferation, optimizing biological response. However, despite their multiple benefits, some disadvantages have been reported, related structural composition or difficulty obtaining ultrafine fibers. Direct electrospinning techniques proposed optimize parameters incorporate biomolecules. continuous advancement biomaterials research will enable better clinical applications consolidation regeneration.

Language: Английский

Citations

0
Application Progress of Multi-Functional Polymer Composite Nanofibers Based on Electrospinning: A Brief Review DOI Open Access
Shuai Ma, An Li, Ligang Pan

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(17), P. 2459 - 2459

Published: Aug. 29, 2024

Nanomaterials are known as the most promising materials of 21st century, among which nanofibers have become a hot research and development topic in academia industry due to their high aspect ratio, specific surface area, molecular orientation, crystallinity, excellent mechanical properties, many other advantages. Electrospinning is important preparation method for thin membranes its controllability, versatility, low cost, simplicity. Adding nanofillers such ceramics, metals, carbon electrospinning polymer solutions prepare composites can further improve strength multi-functionality also provide possibilities widespread applications. Based on rapid field composite nanofibers, this review focuses polyurethane (PU)-based main representative reviews latest practical applications fields sound-absorbing materials, biomedical (including tissue engineering implants, drug delivery systems, wound dressings anti-bacterial health etc.), wearable sensing devices energy harvesters, adsorbent electromagnetic shielding reinforcement materials. Finally, summary performance-application relationship prospects given. This expected some experience theoretical guidance developments related fields.

Language: Английский

Citations

3
Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application DOI Open Access

Leonardo Donati,

Maria Luisa Valicenti,

Samuele Giannoni

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10386 - 10386

Published: Sept. 26, 2024

Mechanosensing and mechanotransduction pathways between the Extracellular Matrix (ECM) cells form essential crosstalk that regulates cell homeostasis, tissue development, morphology, maintenance, function. Understanding these mechanisms involves creating an appropriate support elicits signals to guide cellular functions. In this context, polymers can serve as ideal molecules for producing biomaterials designed mimic characteristics of ECM, thereby triggering responsive closely resemble those induced by a natural physiological system. The generated specific stimuli depend on different or synthetic origins polymers, chemical composition, assembly structure, physical surface properties biomaterials. This review discusses most widely used their customization develop with tailored properties. It examines how biomaterials-based be harnessed replicate functions biological cells, making them suitable biomedical biotechnological applications.

Language: Английский

Citations

3
Electrospun Conductive Polymer Scaffolds: Tailoring Fiber Diameter and Electrical Properties for Tissue Engineering Applications DOI Creative Commons

Zary Adabavazeh,

Narges Johari, Francesco Baino

et al.

Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 112596 - 112596

Published: April 1, 2025

Language: Английский

Citations

0
Electrospinning of Biocompatible Nanofibres for Medical Coatings: Techniques and Applications DOI
Bancha Yingngam,

Kamonrat Suksumrit,

N. Proykratok

et al.

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 214 - 250

Published: Nov. 15, 2024

The development of biocompatible nanofibres through electrospinning is a promising method for engineers in the biomedical field. existing coating technologies medical field have various limitations, and more investigations are needed to improve their biocompatibility, controlled release properties, mechanical strength. Designing new materials that can interact efficiently with biological systems offer numerous functional advantages major challenge device manufacturing tissue engineering. This chapter reviews approaches used create nanofibres, including design, fabrication functionalization. applications these coatings also reviewed. Furthermore, we discuss methods, used, key parameters impact fibre morphology physiochemical properties. Moreover, incorporation bioactive elements drugs into therapeutic explored. biologically friendly be an effective approach improving coatings. Such enhance properties such as drug delivery, regeneration, implant integration, offering enormous potential patient welfare. Future research areas include investigating use advanced procedures enhanced control over nanofibre composition design fabrication.

Language: Английский

Citations

1
Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future Directions DOI Creative Commons
D. Marian, Giuseppe Toro, Giovanbattista D’Amico

et al.

Medicina, Journal Year: 2024, Volume and Issue: 61(1), P. 20 - 20

Published: Dec. 27, 2024

This review explores the recent advancements and ongoing challenges in regenerating alveolar bone, which is essential for dental implants periodontal health. It examines traditional techniques like guided bone regeneration grafting, alongside newer methods such as stem cell therapy, gene 3D bioprinting. Each approach considered its strengths supporting growth integration, especially cases where complex defects make difficult. also looks at different biomaterials, from bioactive scaffolds to nanomaterials, assessing how well they encourage healing. Personalized treatments, customized 3D-printed scaffolds, show promise enhancing formation tissue compatibility. Additionally, signaling molecules, morphogenetic proteins, play a crucial role guiding process of remodeling. Despite these advances, remain-particularly with severe loss refining biomaterials more reliable, long-term outcomes. proposes combining advanced materials, regenerative technologies, personalized approaches achieve effective consistent outcomes oral maxillofacial surgery.

Language: Английский

Citations

1
Flash Sintering of ZrO2-SnO2-ZrSnO4 Composite Nanofibers: Fabrication, Properties, and Biochemical Effects in Drosophila melanogaster DOI
Eda Güneş, Zeynep Çetınkaya

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: 320, P. 129421 - 129421

Published: May 3, 2024

Language: Английский

Citations

1
Investigation of the Effect of Preparation Parameters on the Structural and Mechanical Properties of Gelatin/Elastin/Sodium Hyaluronate Scaffolds Fabricated by the Combined Foaming and Freeze-Drying Techniques DOI Open Access

Mansour T. Qamash,

S. Misagh Imani,

Meisam Omidi

et al.

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(10), P. 408 - 408

Published: Oct. 4, 2024

This paper aimed to evaluate the effects of different preparation parameters, including agitation speed, time, and chilling temperature, on structural mechanical properties a novel gelatin/elastin/sodium hyaluronate tissue engineering scaffold, recently developed by our research group. Fabricated using combination foaming freeze-drying techniques, scaffolds were assessed understand how these parameters influence their morphology, internal microstructure, porosity, properties, degradation behavior. The fabrication process used in this study involved preparing homogeneous aqueous solution containing 8% gelatin, 2% elastin, 0.5% sodium (w/v), which was then subjected at speeds 500, 1000, 1500 rpm for durations 5, 15, 25 min. mixture subsequently frozen −20 °C −80 °C, followed cross-linking. Morphological analyses laser microscopy scanning electron (SEM) demonstrated that had pore sizes ranging from 100 300 µm, are conducive effective cell interaction regeneration. confirmed efficacy combined method creating highly interconnected porous structures. Our findings indicated temperature slightly influenced size. In contrast, higher longer duration times led increased porosity rate but decreased modulus. Mathematical estimators compressive modulus statistical analysis parameters. validated experimentally, with error between estimated experimental values being less than 6% 21%

Language: Английский

Citations

0
Optimizing locally delivered periodontitis therapy: Development of chitosan‐hydroxyapatite‐encapsulated drug via electrospraying DOI
Binpeng Zhang,

Shaofu Yan,

Yao Zhang

et al.

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Abstract This study presents the development of an optimized drug delivery system for periodontitis treatment utilizing chitosan‐hydroxyapatite nanoparticles. Employing electrospraying technique, researchers encapsulated antibiotic amoxicillin within composite matrices while varying concentrations chitosan and hydroxyapatite The resulting microparticles displayed sizes ranging from 276 to 386 μm. Characterization produced encapsulations indicated that higher resulted in formation larger particles with rougher surfaces, increased mechanical strength, enhanced thermal stability. Notably, nanoindentation analysis revealed increase hardness 0.21 0.35 GPa, elastic modulus 5.32 8.72 GPa escalating content, meeting or surpassing requirements load‐bearing regenerative biomaterials. In vitro release assessments exhibited sustained over 24 h, predominantly through diffusion dissolution mechanisms. Formulations lower polymer mineral content showcased elevated rates, F1 encapsulation (0.5% chitosan, 0.2% HAP) achieving a cumulative 78.3 ± 3.2% contrast 65.1 2.7% F5 formulation (2.5% 1% HAP). These selectively modulated overproduction proinflammatory cytokines, including IL‐1β, IL‐6, TNF‐α, gingival fibroblasts osteoblasts without compromising cell viability. An artificial neural network (ANN) model accurately forecasted material properties biological performance formulations based on their compositional variations, yielding correlation coefficients exceeding 0.97. computational platform offers virtual screening tool refining therapies. developed microparticulate demonstrates promising potential prolonged controlled delivery, improved properties, targeted regulation inflammatory response.

Language: Английский

Citations

0