Effect of Agitation and Temporary Immersion on Growth and Synthesis of Antibacterial Phenolic Compounds in Genus Drosera DOI Creative Commons
Wojciech Makowski, Kinga Mrzygłód, Agnieszka Szopa

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1132 - 1132

Published: Sept. 7, 2024

Sundews (Drosera sp.) are the source of biologically active secondary metabolites: phenolic acids, flavonoids, and 1,4-naphtoquinones. Because obtaining them from natural environment is impossible (rare endangered species), in this study modifications traditional tissue cultures grown solid medium (SM), such as agitated (ACs) (cultures liquid with rotary shaking) temporary immersion bioreactors PlantformTM (TIB), were used for multiplication four sundew species: Drosera peltata, indica, regia, binata, simultaneously effective synthesis compounds. Each species cultivated on SM, AC, TIB was tested biomass accumulation, content total phenols selected derivative concentrations (DAD-HPLC), productivity compounds, well its antibacterial activity against two human pathogens: Staphylococcus aureus Escherichia coli. The results showed that type culture should be each separately. Phytochemical analyses metabolites groups 1,4-naphthoquinones can increased by modifying cultivation conditions. D. regia turned out to richest including 1,4-naphtoquinones: plumbagin ramentaceone. Extracts indica strong both pathogens. It has also been shown growth conditions sundews modify level metabolites, thus, their biological activity.

Language: Английский

The Potential of Hydrogel Preparations Containing Plant Materials in Supporting the Treatment of Vaginal and Vulvar Infections—Current State of Knowledge DOI Open Access
Aneta Ostróżka-Cieślik, Monika Michalak, Tomasz Krzysztof Bryś

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 470 - 470

Published: Feb. 11, 2025

Vaginal hydrogels are a modern alternative to solid (tablets, globules) and other semi-solid forms of medication (ointments, creams) in the control pathogenic microorganisms diseases female reproductive tract. This review aims summarize current state knowledge regarding efficacy containing plant materials treatment vaginal vulvar infections. New therapies essential address growing antimicrobial resistance crisis. Google Scholar, Web Science, Cochrane, Medline (PubMed) databases were searched. Twenty-five studies included review, including basic, pre-clinical, clinical studies. The results obtained confirmed therapeutic potential raw embedded polymer matrix hydrogels. However, due small number trials conducted, further research this area is needed.

Language: Английский

Citations

0
Distribution of Acetogenic Naphthoquinones in Droseraceae and Their Chemotaxonomic Utility DOI Creative Commons
Jan Schlauer, Andreas Fleischmann,

Siegfried R. H. Hartmeyer

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(2), P. 97 - 97

Published: Feb. 3, 2024

Chemotaxonomy is the link between state of art in analytical chemistry and systematic classification phylogenetic analysis biota. Although characteristic secondary metabolites from diverse biotic sources have been used pharmacology biological systematics since dawn mankind, only comparatively recently established reproducible methods allowed precise identification distinction structurally similar compounds. Reliable, rapid screening like TLC (Thin Layer Chromatography) can be to investigate sufficiently large numbers samples for chemotaxonomic purposes. Using distribution patterns mutually exclusive naphthoquinones, it demonstrated this review how a simple set chemical data representative sample closely related species sundew family (Droseraceae, Nepenthales) provides taxonomically phylogenetically informative signal within investigated group beyond.

Language: Английский

Citations

1
Effect of Agitation and Temporary Immersion on Growth and Synthesis of Antibacterial Phenolic Compounds in Genus Drosera DOI Creative Commons
Wojciech Makowski, Kinga Mrzygłód, Agnieszka Szopa

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1132 - 1132

Published: Sept. 7, 2024

Sundews (Drosera sp.) are the source of biologically active secondary metabolites: phenolic acids, flavonoids, and 1,4-naphtoquinones. Because obtaining them from natural environment is impossible (rare endangered species), in this study modifications traditional tissue cultures grown solid medium (SM), such as agitated (ACs) (cultures liquid with rotary shaking) temporary immersion bioreactors PlantformTM (TIB), were used for multiplication four sundew species: Drosera peltata, indica, regia, binata, simultaneously effective synthesis compounds. Each species cultivated on SM, AC, TIB was tested biomass accumulation, content total phenols selected derivative concentrations (DAD-HPLC), productivity compounds, well its antibacterial activity against two human pathogens: Staphylococcus aureus Escherichia coli. The results showed that type culture should be each separately. Phytochemical analyses metabolites groups 1,4-naphthoquinones can increased by modifying cultivation conditions. D. regia turned out to richest including 1,4-naphtoquinones: plumbagin ramentaceone. Extracts indica strong both pathogens. It has also been shown growth conditions sundews modify level metabolites, thus, their biological activity.

Language: Английский

Citations

1