Science Advances,
Journal Year:
2024,
Volume and Issue:
10(38)
Published: Sept. 20, 2024
Sarcopenia
is
characterized
by
accelerated
muscle
mass
and
function
loss,
which
burdens
challenges
public
health
worldwide.
Several
studies
indicated
that
selenium
deficiency
associated
with
sarcopenia;
however,
the
specific
mechanism
remains
unclear.
Here,
we
demonstrated
selenoprotein
W
(SELENOW)
containing
in
form
of
selenocysteine
functioned
sarcopenia.
SELENOW
expression
up-regulated
dexamethasone
(DEX)–induced
atrophy
age-related
sarcopenia
mouse
models.
Knockout
(KO)
profoundly
aggravated
process
loss
two
Mechanistically,
KO
suppressed
RAC1-mTOR
cascade
interaction
between
RAC1
induced
imbalance
protein
synthesis
degradation.
Consistently,
overexpression
vivo
vitro
alleviated
myotube
DEX.
played
a
role
regulated
genes
aging.
Together,
our
study
uncovered
provides
promising
evidence
for
prevention
treatment
Journal of the Science of Food and Agriculture,
Journal Year:
2024,
Volume and Issue:
104(12), P. 7656 - 7667
Published: May 21, 2024
Bamboo
leaf
flavonoids
(BLF)
are
the
main
bioactive
ingredients
in
bamboo
leaves.
They
have
antioxidant,
anti-inflammatory,
antibacterial,
and
other
effects.
In
this
study,
effects
of
dietary
BLF
on
growth
performance,
immune
response,
antioxidant
capacity,
intestinal
microbiota
broilers
were
investigated.
A
total
288
divided
into
three
groups
with
eight
replicates
12
birds
each
replicate.
Broilers
fed
a
basic
diet
or
supplemented
1000
2000
mg
kg
Animals,
Journal Year:
2024,
Volume and Issue:
14(5), P. 764 - 764
Published: Feb. 29, 2024
Four
trials
were
conducted
to
establish
a
protein
and
amino
acid
requirement
model
for
layer
chicks
over
0–6
weeks
by
using
the
analytical
factorization
method.
In
trial
1,
total
of
90
one-day-old
Jing
Tint
6
with
similar
body
weight
selected
determine
growth
curve,
carcass
feather
deposition,
patterns
proteins.
2
3,
24
seven-day-old
thirty-five-day-old
maintenance
requirements,
pattern,
net
utilization
rate.
4,
ten-day-old
thirty-eight-day-old
standard
terminal
ileal
digestibility
acids.
The
fed
either
corn–soybean
basal
diet,
low
nitrogen
or
nitrogen-free
diet
throughout
different
trials.
Gompertz
equation
showed
that
there
is
functional
relationship
between
age,
described
as
BWt(g)
=
2669.317
×
exp(−4.337
exp(−0.019t)).
Integration
test
results
gave
comprehensive
dynamic
could
accurately
calculate
weekly
requirements
chicks.
By
applying
model,
it
was
found
during
6-week
period
21.15,
20.54,
18.26,
18.77,
17.79,
16.51,
respectively.
model-predicted
follows:
Aspartic
(0.992–1.284),
Threonine
(0.601–0.750),
Serine
(0.984–1.542),
Glutamic
(1.661–1.925),
Glycine
(0.992–1.227),
Alanine
(0.909–0.961),
Valine
(0.773–1.121),
Cystine
(0.843–1.347),
Methionine
(0.210–0.267),
Isoleucine
(0.590–0.715),
Leucine
(0.977–1.208),
Tyrosine
(0.362–0.504),
Phenylalanine
(0.584–0.786),
Histidine
(0.169–0.250),
Lysine
(0.3999–0.500),
Arginine
(0.824–1.147),
Proline
(1.114–1.684),
Tryptophan
(0.063–0.098).
conclusion,
this
study
constructed
brooding
period,
providing
an
important
insight
improve
precise
feeding
through
calculation.
Poultry Science,
Journal Year:
2025,
Volume and Issue:
104(4), P. 104840 - 104840
Published: Jan. 22, 2025
This
study
aimed
to
evaluate
the
effects
of
butyrate,
butyric
glycerides
(BG)
and
their
combination
with
sodium
selenite
(SeNa)
or
hydroxy-selenomethionine
(OH-SeMet)
on
performance
egg
quality
laying
hens
in
post-peak
period
as
well
potential
mechanism.
A
total
900
45-week-old
Hy-Line
brown
were
randomly
allocated
5
treatment
groups
(n
=
10
replicates/diet,
18
hens/replicate).
The
fed
basal
diet
supplemented
0.3
mg/kg
selenium
from
SeNa
(Control),
Control
plus
240
acid
coated
butyrate
(CB),
glycerides,
OH-SeMet
(CB+OH-SeMet)
(BG+OH-SeMet),
respectively,
for
20
weeks.
Serum,
liver,
isthmus,
uterus,
jejunum
collected
at
end
trial
biochemistry,
histology,
redox
status,
gene
expression
analysis.
Compared
Control,
diets
BG,
CB+OH-SeMet
BG+OH-SeMet
increased
(p
<
0.05)
average
weight
(0.6-2.2
%),
while
only
(7.1
%)
egg-laying
rate
(4.6
decreased
feed/egg
ratio
(5.0
throughout
whole
experiment.
Furthermore,
reduced
content
IL-6
alanine
aminotransferase
(15.4-32.5
elevated
IgA,
IgY,
IgM
protein
(18.7-26.8
serum
comparison
Control.
Notably,
dietary
supplementation
performed
more
effective
antioxidant
capacity
decreasing
malondialdehyde
(16.4-27.9
increasing
activity
glutathione
peroxidase
(17.6-36.3
various
tissues.
Further
experiment
revealed
that
regulated
lipid
metabolism
by
Carnitine
palmitoyltransferase
1A
(CPT1A)
Lipoprotein
lipase
(LPL)
liver.
In
conclusion,
BG
could
improve
via
enhancement
regulation
metabolism.
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 7, 2025
Abstract
Background
AFB
1
-8,9-exo-epoxide
(AFBO)
is
the
highly
toxic
product
of
Aflatoxin
B
(AFB
).
Glutathione
S
-transferases
(GSTs)
play
pivotal
roles
in
detoxifying
by
catalyzing
conjugation
AFBO
with
glutathione
(GSH).
Although
there
are
over
20
GST
isozymes
that
have
been
identified
chicken,
involved
detoxification
process
not
yet.
The
objective
this
study
was
to
determine
which
played
key
role
.
Results
A
total
17
pcDNA3.1(+)-GST
isozyme
plasmids
were
constructed
and
genes
overexpressed
80–2,500,000
folds
chicken
Leghorn
male
hepatoma
(LMH)
cells.
Compared
treatment,
overexpression
GSTA2X,
GSTA3,
GSTT1L,
GSTZ1-1,
GSTZ1-2
increased
cell
viability
6.5%–17.0%
LMH
Moreover,
five
reduced
release
lactate
dehydrogenase
reactive
oxygen
species
8.8%–64.4%,
57.2%–77.6%,
respectively,
as
well
enhanced
production
AFBO-GSH
15.8%–19.6%,
thus
mitigating
DNA
damage
induced
After
comprehensive
evaluation
various
indicators,
GSTA2X
displayed
best
effects
against
expressed
Pichia
pastoris
X-33
its
enzymatic
properties
for
GSH
showed
optimum
temperature
pH
20–25
°C
7.6–8.6
kinetic
parameter
V
max
0.23
nmol/min/mg
Michaelis
constant
86.05
μmol/L
substrate.
Conclusions
In
conclusion,
detoxification,
will
provide
new
remediation
strategies
prevent
aflatoxicosis
chickens.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(5), P. 525 - 525
Published: April 27, 2025
The
objective
of
this
study
was
to
determine
whether
hydroxy-selenomethionine
(OH-SeMet)
exerts
better
protective
effects
on
sows
against
heat
stress
than
sodium
selenite
(SeNa)
or
seleno-yeast
(SeY).
A
total
60
(Landrace
×
Yorkshire)
were
randomly
allocated
into
the
three
groups
and
fed
a
base
diet
supplemented
with
SeNa,
SeY,
OH-SeMet
at
0.3
mg
Se/kg
under
condition
for
reproductive
cycle.
Compared
SeNa
could
more
effectively
sustain
offspring
growth
performance,
as
evidenced
by
an
increased
number
live-born
piglets,
higher
litter
weight
day
21,
greater
body
gain
from
days
1
21.
effective
in
supporting
endogenous
redox
systems,
shown
enhanced
levels
TXNRD
GSH
reduced
GSSG
serum
sows,
improved
T-AOC,
TXNRD,
alongside
decreased
MDA
heightened
T-AOC
jejunum
piglets.
Furthermore,
among
two
tested
organic
Se
sources,
SeY
regulating
immune
responses
compared
SeNa.
inflammation-related
markers
CRP,
HP,
MAP,
LPS,
IL-1β,
IL-6,
TNF-α,
some
all
which
their
offspring.
In
addition,
also
showed
glucose,
TG,
NEFA
levels,
along
elevated
insulin
sows.
Correspondingly,
forms
Se,
particularly
those
gut
protection
sows’
offspring,
indicated
crypt
depth
villus
height/crypt
ratio
duodenum,
jejunum,
ileum
Specifically,
upregulated
expression
selenoproteins
(GPX6,
TXNRD3,
GPX4,
SELENON),
tight
junction
protein
(ZO-1),
host
defense
peptide
gene
(pBD1,
pBD2,
pBD3,
NPG3,
NPG4),
downregulating
inflammation
factor
(IL-1β,
IL-6
TNF-α)
pro-apoptotic
(P53)
Taken
together,
mitigated
adverse
induced
