Longitudinal Symptom Burden and Pharmacologic Management of Catatonia in Autism With Intellectual Disability: An Observational Study

Autism Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

ABSTRACT Catatonia is a highly morbid psychomotor and affective disorder, which can affect autistic individuals with without intellectual disability. Catatonic symptoms are treatable pharmacotherapy electroconvulsive therapy, but the longitudinal effectiveness of these treatments in has not been described. We conducted prospective observational cohort study patients autism co‐morbid catatonia who received outpatient care specialized clinic from July 1, 2021 to May 31, 2024. Data investigating pharmacologic interventions, clinical measures including Bush Francis Rating Scale (BFCRS), Kanner Severity (KCS), Examination (KCE), Clinical Global Impression—Improvement (CGI‐I) were collected. Forty‐five treated during period. The mean age was 15.6 (SD = 7.9) years [Mdn 16.0, range 6.0–31.0]. Forty‐one (91.1%) met criteria for co‐occurring All pharmacotherapy. Forty‐four (97.8%) benzodiazepines maximal daily dose 17.4 mg 15.8) lorazepam equivalents. Thirty‐five (77.8%) required more than one medication class treatment. Sixteen (35.6%) therapy. Fourteen (31.1%) attempted taper off after achieving improvement period; these, 5 (11.1%) successfully tapered off, remaining 9 (17.8%) discontinued due return catatonic symptoms. Statistically significant observed across all domains except KCS. However, majority remained at least partially symptomatic over Three (6.7%) died Despite improvements while receiving gold standard psychopharmacologic management catatonia, chronic period, few able discontinue benzodiazepine Notably, open label design this limiting factor when interpreting results.

Language: Английский

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Understanding profound autism: implications for stigma and supports

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 22, 2024

Introduction Societal perceptions and lack of understanding autism spectrum disorder can be stigmatizing for autistic individuals their families. This may particularly the case who meet criteria profound autism. Despite considerable service needs this marginalized group, there is little data on prevalence autism, nor experiences those with Methods The current study leveraged a mixed-methods approach to address these gaps. First, was examined in six samples—three from United States three Western Europe. Second, inductive thematic analysis used code interviews 20 caregivers profoundly adults. Results varied widely across samples—from 11% 48%. There were also notable differences between samples by gender, race, ethnicity. Two overarching themes identified via analysis: Community Perceptions Autism Family Support Needs Advocacy Challenges . Though not directly asked about stigmatization during interviews, 85% reported at least one instance perceived stigma. Discussion Future research should continue examine unique families life course.

Language: Английский

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Effects of Using Prompts During Parent–Child Shared Reading on the Language Development of Mildly Autistic Children

Journal of Autism and Developmental Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Language: Английский

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Examining the Prevalence, Characteristics, and Potential Links Between Skin Disorders and Autism Spectrum Disorder (ASD)

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 469 - 469

Published: Jan. 13, 2025

Background: Increasing evidence indicates that skin disorders may contribute to an increased risk of autism spectrum disorder (ASD). They can affect the quality life, and they have impact on social isolation, behavioral problems, cognitive scores, some subscales ASD. Methods: This study was online questionnaire-based, observational, cross-sectional conducted during period from August 2022 through January 2023 examine dermatological manifestations among ASD individuals compared controls. Descriptive non-parametric tests were used for data analysis. Results: A total 363 with diseases interviewed period. In total, 189 (52.1%) participants autistic 174 (47.9%) Asthma, anxiety, depression, autoimmune disease persistent in group controls (p < 0.001). The results also show skin, food, respiratory allergies statistically significantly associated (50%, 22.2%, 14.8%, respectively) (26.4%, 10.3%, 7.5%, 0.05). most prevalent eczema (15.5%), followed by dry (14.9%) acne (10.3%). These showed a significant association 0.0001). Conclusions: Our findings indicate atopic comorbidities, including eczema, asthma, allergies, are large population-based is warranted clarify prevalence ASD, coupled between comorbidities determine relationship precisely.

Language: Английский

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Sex‐Differential Trajectories of Domain‐Specific Associations Between Autistic Traits and Co‐Occurring Emotional‐Behavioral Concerns in Autistic Children

Autism Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

ABSTRACT Assessing autistic traits alongside co‐occurring emotional/behavioral concerns (EBCs) is challenging due to their overlap in clinical presentations, which can vary by age and sex. This study aimed investigate domain‐specific associations between EBCs–including anxiety, affective, attention‐deficit/hyperactivity, oppositional‐defiant problems–across childhood boys girls. We prospectively followed 389 children (84% male) diagnosed with autism at ages 2–5 years, using the Social Responsiveness Scale (SRS) Child Behavior Checklist (CBCL) across eight timepoints until 12. Moderated nonlinear factor analysis was used identify adjust for measurement non‐invariance of SRS items age, sex, EBCs. The adjusted scores were then sex‐moderated time‐varying modeling Several domains social‐interaction difficulties repetitive mannerisms showed significant intercept bias level anxiety ADHD (effect size r > 0.20). In boys, strong observed social‐communication EBCs around 7–9, tended diminish late childhood. contrast, girls stable or intensifying associations, particularly into Results revealed after addressing item‐level biases. varying over time highlight importance continuous monitoring promptly address children's sex‐differential mental health needs. These findings emphasize benefits refining behavioral constructs adopting a nuanced developmental approach critical periods symptom coupling/decoupling informing evaluation service provision.

Language: Английский

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Trajectories of autism symptom severity for boys and girls across childhood

Autism, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Girls, more than boys, experience a decrease in the severity of autism symptoms during childhood. It is unclear, however, which specific autistic behaviors change for girls boys. Trajectories were evaluated using Autism Diagnostic Observation Schedule-calibrated scores (ADOS-CSS). Change behavioral characteristics was assessed by studying individual ADOS items 183 children (55 girls) from age 3–to-11 years. Girls decreased total symptom (ADOS-CSS) and restricted/repetitive behavior (RRB-CSS) across childhood, while boys remained stable both. showed decreasing-severity trajectories seven an increasing-trajectory one item. Boys six increasing-severity three items. with higher ADOS-CSS at 3 likely to other girls. our study mostly improved or its especially related being socially engaged responsive. Boys’ variable over time included both improvement worsening, social that are key interaction. high early levels can potentially substantially Lay Abstract The overall tend but we do not know drive this difference. We studied how characteristic found improve remain level their They responsive others. Furthermore, it possible show major some worsened engaging interactions.

Language: Английский

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A cross-sectional study of public knowledge and stigma towards autism spectrum disorder in Lebanon

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 5, 2025

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that requires public understanding to foster acceptance and reduce stigma. This study aimed evaluate ASD knowledge stigma among the Lebanese population factors influencing them. An online cross-sectional was conducted between February July 2022 adults. Participants completed self-administered structured questionnaire comprised sociodemographic section two validated scales serving study's purpose (The Stigma Knowledge Questionnaire (ASK-Q) The Social Distance Scale). A total of 949 participants filled out questionnaire. More than half them had adequate autism diagnosis symptoms (57.9%), while only 6.6% 9.6% showed its etiology treatment, respectively. Additionally, 83.4% did not endorse toward autism. multivariate analysis taking score subscales as dependent variables declaring prior significantly associated with better (Beta = 1.38) higher 0.26). Furthermore, - 0.06) declared 0.62) were lower social distance. These findings highlight need for targeted awareness campaigns address gaps further in Lebanon.

Language: Английский

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Prototypical autism: New diagnostic criteria and asymmetrical bifurcation model

Acta Psychologica, Journal Year: 2023, Volume and Issue: 237, P. 103938 - 103938

Published: May 15, 2023

The current "autism spectrum" DSM 5 diagnostic criteria and autism standardized instruments promote considerable heterogeneity or clinical indecision may be detrimental to the advancement of fundamental research on mechanisms. To increase specificity reorient towards core autistic presentations, we propose new for prototypical during age 2- 5-years. We include within other non-dominant, familiarly aggregated phenomena sharing asymmetrical developmental bifurcations, such as twin pregnancy, left handedness, breech presentation/delivery. Following this model, nature, trajectory, positive/negative signs structure would result from polarized problem whether not language information is processed in a socially biased manner. Prototypical follow canonical trajectory by which gradual decline social bias processing incoming information, overtly beginning at end first year, bifurcates into presentation second half year life. This bifurcation event followed plateau, these atypicalities show maximal stringency distinctiveness, then ultimately, most cases, partial normalization. During plateau period, orientation towards, of, considerably modified, with an absence contrasting high level interest complex, unbiased independently its non-social nature. Integrating bifurcations explain deleterious neurological genetic markers presence familial transmission presentations.

Language: Английский

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Autistic People’s Perspectives on Functioning Labels and Associated Reasons, and Community Connectedness

Journal of Autism and Developmental Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: March 20, 2024

Language: Английский

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Toward a functional classification for autism in adulthood

Autism Research, Journal Year: 2024, Volume and Issue: 17(10), P. 2105 - 2119

Published: July 19, 2024

Abstract Autism spectrum disorder (ASD) is a heterogeneous condition that affects development and functioning from infancy through adulthood. Efforts to parse the heterogeneity of autism subgroups such as Asperger's Profound have been controversial, consistently struggled with issues reliability, validity, interpretability. Nonetheless, methods for successfully identifying clinically meaningful within are needed ensure research, interventions, services address range needs experienced by autistic individuals. The purpose this study was generate test whether simple set questions, organized in flowchart, could be used clinical practice research differentiate based on individuals' level functioning. Once generated, also compared recently proposed administrative category groupings standardized adaptive measures. Ninety‐seven adults or related neurodevelopmental disorders participating longstanding longitudinal study, their caregivers if they not answer themselves, completed phone interviews when participants were ~30 years old. Information these vignettes summarizing characteristics aspects daily lives each participant (e.g., language level, vocational activities, social relationships). Three expert clinicians then classify support needs. Meaningfully distinct sample identified which reliably distinguished one another. Implications categorizations future directions discussed.

Language: Английский

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