Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans DOI Creative Commons

Sophie Hiel,

Laure B. Bindels, Barbara D. Pachikian

et al.

American Journal of Clinical Nutrition, Journal Year: 2019, Volume and Issue: 109(6), P. 1683 - 1695

Published: Jan. 8, 2019

Inulin-type fructans (ITFs) are a type of fermentable dietary fiber that can confer beneficial health effects through changes in the gut microbiota. However, their effect on sensitivity and nutritional behavior is matter debate.We evaluated impact consuming ITF-rich vegetables daily microbiota, gastro-intestinal symptoms, food-related healthy individuals.A single group-design trial was conducted 26 individuals. During 2 wk, participants were instructed to adhere controlled diet based (providing mean intake 15 g ITF/d). Three test days organized: before after intervention 3 wk returning usual diet. We assessed nutrient intake, behavior, fecal microbiota composition, microbial fermentation, gastrointestinal symptoms.The major modifications during an increased proportion Bifidobacterium genus, decreased level unclassified Clostridiales, tendency decrease Oxalobacteraceae. These reversed intervention. The volunteers showed greater satiety, reduced desire eat sweet, salty, fatty food, trend increase hedonic attitudes towards some inulin-rich vegetables. Only flatulence episodes reported intervention, whereas intestinal discomfort, inversely associated with Clostridium cluster IV Ruminococcus callidus, improved at end intervention.A higher consumption allows substantial well-tolerated fiber, which may turn improve behavior. Moreover, it leads composition function. This registered clinicaltrial.gov as NCT03540550.

Language: Английский

Cancer and the Microbiome—Influence of the Commensal Microbiota on Cancer, Immune Responses, and Immunotherapy DOI
Vyara Matson,

Carolina Soto Chervin,

Thomas F. Gajewski

et al.

Gastroenterology, Journal Year: 2020, Volume and Issue: 160(2), P. 600 - 613

Published: Nov. 28, 2020

Language: Английский

Citations

281
Why does the microbiome affect behaviour? DOI
Katerina V.‐A. Johnson, Kevin R. Foster

Nature Reviews Microbiology, Journal Year: 2018, Volume and Issue: 16(10), P. 647 - 655

Published: April 24, 2018

Language: Английский

Citations

279
The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective DOI
Sofia Cussotto,

Kiran V. Sandhu,

Timothy G. Dinan

et al.

Frontiers in Neuroendocrinology, Journal Year: 2018, Volume and Issue: 51, P. 80 - 101

Published: May 16, 2018

Language: Английский

Citations

275
Stress, depression, diet, and the gut microbiota: human–bacteria interactions at the core of psychoneuroimmunology and nutrition DOI
Annelise A. Madison, Janice K. Kiecolt‐Glaser

Current Opinion in Behavioral Sciences, Journal Year: 2019, Volume and Issue: 28, P. 105 - 110

Published: March 26, 2019

Language: Английский

Citations

262
Sex differences in the gut microbiome–brain axis across the lifespan DOI Open Access
Eldin Jašarević, Kathleen E. Morrison, Tracy L. Bale

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2016, Volume and Issue: 371(1688), P. 20150122 - 20150122

Published: Feb. 1, 2016

In recent years, the bidirectional communication between gut microbiome and brain has emerged as a factor that influences immunity, metabolism, neurodevelopment behaviour. Cross-talk begins early in life immediately following transition from sterile utero environment to one is exposed changing complex microbial milieu over lifetime. Once established, integrates information autonomic enteric nervous systems, neuroendocrine neuroimmune signals, peripheral immune metabolic signals. Importantly, composition functional potential of undergoes many transitions parallel dynamic periods development maturation for which distinct sex differences have been identified. Here, we discuss sexually dimorphic development, maintenance microbiome–brain axis, therein important disease risk resilience throughout lifespan.

Language: Английский

Citations

247
Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta‐analysis of randomized controlled trials DOI Creative Commons
Heidi Borgeraas,

Line Kristin Johnson,

Julie Skattebu

et al.

Obesity Reviews, Journal Year: 2017, Volume and Issue: 19(2), P. 219 - 232

Published: Oct. 18, 2017

Summary A systematic review and meta‐analysis of randomized controlled trials was conducted to examine the effects probiotic supplementation on body weight, mass index (BMI), fat percentage in subjects with overweight (BMI 25–29.9 kg m −2 ) or obesity ≥30 ). MEDLINE, EMBASE Cochrane Central Register Controlled Trials were searched for studies published between 1946 September 2016. meta‐analysis, using a random model, performed calculate weighted mean difference intervention control groups. Of 800 identified through literature search, 15 finally included. The comprised total 957 (63% women), BMI being 27.6 duration interventions ranging from 3 12 weeks. Administration probiotics resulted significantly larger reduction weight (weighted [95% confidence interval]; −0.60 [−1.19, −0.01] kg, I 2 = 49%), (−0.27 [−0.45, −0.08] , 57%) (−0.60 [−1.20, %, 19%), compared placebo; however, effect sizes small. non‐significant (−0.42 [−1.08, 0.23] 84%).

Language: Английский

Citations

236
Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease DOI Open Access
Péter Hegyi, József Maléth, Julian R.F. Walters

et al.

Physiological Reviews, Journal Year: 2018, Volume and Issue: 98(4), P. 1983 - 2023

Published: Aug. 1, 2018

Epithelial cells line the entire surface of gastrointestinal tract and its accessory organs where they primarily function in transporting digestive enzymes, nutrients, electrolytes, fluid to from luminal contents. At same time, epithelial are responsible for forming a physical biochemical barrier that prevents entry into body harmful agents, such as bacteria their toxins. Dysregulation transport is associated with pathogenesis number conditions throughout intestine, inflammatory bowel disease, chronic diarrhea, pancreatitis, reflux esophagitis, cancer. Driven by discovery specific receptors on intestinal cells, new insights mechanisms control synthesis enterohepatic circulation, growing appreciation roles bioactive bacterial metabolites, bile acids currently receiving great deal interest critical regulators health disease. This review aims summarize recent advances this field highlight how now emerging exciting targets disease intervention.

Language: Английский

Citations

230
Microbiota in anorexia nervosa: The triangle between bacterial species, metabolites and psychological tests DOI Creative Commons
Francesca Borgo, Alessandra Riva,

Alberto Benetti

et al.

PLoS ONE, Journal Year: 2017, Volume and Issue: 12(6), P. e0179739 - e0179739

Published: June 21, 2017

Anorexia nervosa (AN) is a psychiatric disease with devastating physical consequences, pathophysiological mechanism still to be elucidated. Metagenomic studies on anorexia have revealed profound gut microbiome perturbations as possible environmental factor involved in the disease. In this study we performed comprehensive analysis integrating data microbiota clinical, anthropometric and psychological traits gain new insight pathophysiology of AN. Fifteen AN women were compared fifteen age-, sex- ethnicity-matched healthy controls. diet was characterized by significant lower energy intake, but macronutrient highlighted restriction only fats carbohydrates consumption. Next generation sequencing showed that intestinal significantly affected at every taxonomic level, showing increase Enterobacteriaceae, archeon Methanobrevibacter smithii On contrary, genera Roseburia, Ruminococcus Clostridium, depleted, line observed reduction total short chain fatty acids, butyrate, propionate. Butyrate concentrations inversely correlated anxiety levels, whereas propionate directly insulin levels relative abundance Roseburia inulinivorans, known producer. BMI represented best predictive value for dysbiosis metabolic alterations, negative correlation Bacteroides uniformis (microbiota), alanine aminotransferase (liver function), psychopathological scores (obsession-compulsion, anxiety, depression), positive white blood cells count. conclusion, our findings corroborate hypothesis could take part neurobiology, particular sustaining persistence alterations eventually result relapses after renourishment therapy, causality needs proven.

Language: Английский

Citations

224
The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View DOI Creative Commons
João B. Xavier, Vincent B. Young,

Joseph D. Skufca

et al.

Trends in cancer, Journal Year: 2020, Volume and Issue: 6(3), P. 192 - 204

Published: Feb. 7, 2020

The collection of microbes that live in and on the human body - microbiome can impact cancer initiation, progression, response to therapy, including immunotherapy. mechanisms by which microbiomes cancers yield new diagnostics treatments, but much remains unknown. interactions between microbes, diet, host factors, drugs, cell-cell within itself likely involve intricate feedbacks, no single component explain all behavior system. Understanding role host-associated microbial communities systems will require a multidisciplinary approach combining ecology, immunology, cell biology, computational biology approach.

Language: Английский

Citations

201
Making Sense of … the Microbiome in Psychiatry DOI Creative Commons
Thomaz F. S. Bastiaanssen, Caitlin S.M. Cowan, Marcus J. Claesson

et al.

The International Journal of Neuropsychopharmacology, Journal Year: 2018, Volume and Issue: 22(1), P. 37 - 52

Published: Aug. 2, 2018

Microorganisms can be found almost anywhere, including in and on the human body. The collection of microorganisms associated with a certain location is called microbiota, its collective genetic material referred to as microbiome. largest population body resides gastrointestinal tract; thus, it not surprising that most investigated microbiome gut On average, hosts microbes from more than 60 genera contains cells has been shown influence many aspects host health, recently brain.Several modes interaction between brain have discovered, via synthesis metabolites neurotransmitters, activation vagus nerve, immune system. A growing work implicating variety psychological processes neuropsychiatric disorders. These include mood anxiety disorders, neurodevelopmental disorders such autism spectrum disorder schizophrenia, even neurodegenerative Alzheimer's Parkinson's diseases. Moreover, probable psychotropic medications an impact microbiome.Here, overview will provided for bidirectional role age-associated cognitive decline, neurological psychiatric Furthermore, primer common microbiological bioinformatics techniques used interrogate provided. This review meant equip reader this exciting research area permeating all areas biological psychiatry research.

Language: Английский

Citations

198