Germ cell tumors, cell surface markers, and the early search for human pluripotent stem cells DOI Creative Commons
Peter W. Andrews

BioEssays, Journal Year: 2024, Volume and Issue: 46(12)

Published: Aug. 8, 2024

Abstract Many strands of research by different groups, starting from teratocarcinomas in the laboratory mouse, later moving corresponding human tumors, contributed to isolation and description pluripotent stem cells (PSCs). In this review, I highlight contributions my own research, particularly at Wistar Institute during 1980s, when with colleagues we characterized one first clonal lines embryonal carcinoma (EC) cells, teratocarcinomas, identified key features including cell surface antigen markers that have since found a place study exploitation PSC. Much depended upon close teamwork colleagues, many other laboratories, who expertise experience. It was also often driven circumstance chance rather than pursuit grand design.

Language: Английский

Misconceptions Thrive in the Field of Cancer as Technological Advances Continue to Confuse Stem Cell Biology DOI
Deepa Bhartiya,

Shruti Dutta,

Anish Tripathi

et al.

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

1
The mutual impacts of stem cells and sleep: opportunities for improved stem cell therapy DOI Creative Commons
Sharif Moradi, Masoumeh Nouri, Mohammad‐Taher Moradi

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 29, 2025

Abstract Sleep is an indispensable physiological function regulated by circadian rhythms, which influence the biological pathways and overall health of body. crucial for maintenance restoration bodily systems, disturbances can lead to various sleep disorders, impair both mental physical health. Treatment options these disorders encompass lifestyle modifications, psychotherapy, medications, therapies such as light therapy surgery. Not only deprivation has a significant impact on essential organs, but it also influences types stem cells in In this review, we explore connection between cells, highlighting how rhythms regulate cell activities that are vital tissue regeneration homeostasis. Disruptions hinder self-renewal, homing, proliferation, function, differentiation, thereby affecting We discuss transplantation their products may help improve quality affects behavior, implications therapies. Notably, while certain transplantations disrupt sleep, enhancing efficacy Finally, be utilized model offering valuable insights into underlying mechanisms.

Language: Английский

Citations

0
Germ cell tumors, cell surface markers, and the early search for human pluripotent stem cells DOI Creative Commons
Peter W. Andrews

BioEssays, Journal Year: 2024, Volume and Issue: 46(12)

Published: Aug. 8, 2024

Abstract Many strands of research by different groups, starting from teratocarcinomas in the laboratory mouse, later moving corresponding human tumors, contributed to isolation and description pluripotent stem cells (PSCs). In this review, I highlight contributions my own research, particularly at Wistar Institute during 1980s, when with colleagues we characterized one first clonal lines embryonal carcinoma (EC) cells, teratocarcinomas, identified key features including cell surface antigen markers that have since found a place study exploitation PSC. Much depended upon close teamwork colleagues, many other laboratories, who expertise experience. It was also often driven circumstance chance rather than pursuit grand design.

Language: Английский

Citations

1