Luteolin: A promising natural agent in management of pain in chronic conditions

Frontiers in Pain Research, Journal Year: 2023, Volume and Issue: 4

Published: March 1, 2023

Pain due to chronic conditions is a frequent and insufficiently addressed problem. Current drug options for pain management (either in cases of inflammatory or neuropathy) do not adequately treat pain. Moreover, they are associated with important adverse events long term use. Luteolin flavonoid widely present the plant kingdom its sources have been assembled comprehensive list this paper. has shown several research studies range pharmacological properties; anti-inflammatory, antioxidant, neuroprotective, analgesic. In article, we summarize effects potential benefits from introducing luteolin as an adjuvant agent established protocols management. We review most indicative vivo vitro evidence how can target molecular pathways involved pathogenesis neuropathic The data reviewed strongly support luteolin's promising raise need further clinical trials that establish role practice.

Language: Английский

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Recent advancements in deciphering the therapeutic properties of plant secondary metabolites: phenolics, terpenes, and alkaloids

Plant Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 211, P. 108674 - 108674

Published: April 30, 2024

Language: Английский

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Luteolin for neurodegenerative diseases: a review

Pharmacological Reports, Journal Year: 2024, Volume and Issue: 76(4), P. 644 - 664

Published: June 21, 2024

Neurodegenerative diseases such as Parkinson's disease, Alzheimer's Huntington's and multiple sclerosis affect millions of people around the world. In addition to age, which is a key factor contributing development all neurodegenerative diseases, genetic environmental components are also important risk factors. Current methods treating mostly symptomatic do not eliminate cause disease. Many studies focus on searching for natural substances with neuroprotective properties that could be used an adjuvant therapy in inhibition neurodegeneration process. These compounds include flavonoids, luteolin, showing significant anti-inflammatory, antioxidant, activity. Increasing evidence suggests luteolin may confer protection against neurodegeneration. this review, we summarize scientific reports from preclinical vitro vivo regarding beneficial effects diseases. Luteolin was studied most extensively various models disease but there several its Though very limited, possible protective discussed here. Overall, although show potential benefits disorders, clinical therapeutic efficacy still deficient.

Language: Английский

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Bioinformatics and Deep Learning Approach to Discover Food-Derived Active Ingredients for Alzheimer’s Disease Therapy

Foods, Journal Year: 2025, Volume and Issue: 14(1), P. 127 - 127

Published: Jan. 4, 2025

Alzheimer’s disease (AD) prevention is a critical challenge for aging societies, necessitating the exploration of food ingredients and whole foods as potential therapeutic agents. This study aimed to identify natural compounds (NCs) with in AD using an innovative bioinformatics-integrated deep neural analysis approach, combining computational predictions molecular docking vitro experiments comprehensive evaluation. We employed NCs Disease Discovery (BioDeepNat) application data collected from chemical databases. Random forest regression models were utilized predict IC50 (pIC50) values ligands interacting AD-related target proteins, including acetylcholinesterase (AChE), amyloid precursor protein (APP), beta-secretase 1 (BACE1), microtubule-associated tau (MAPT), presenilin-1 (PSEN1), tumor necrosis factor (TNF)-α, valosin-containing (VCP). Their activities then validated through Autodock Vina. Predictions by identified 166 effects on across seven demonstrating outstanding recall performance. The top five sources these predicted black walnut, safflower, ginger, fig, corn, pepper. Statistical clustering methodologies segregated into six well-defined groups, each characterized convergent structural signatures. systematic examination structure–activity relationships uncovered differential patterns among clusters, illuminating sophisticated correlation between properties biological activity. Notably, high activity, such astragalin, dihydromyricetin, coumarin, medium luteolin, showed promising improving cell survival reducing lipid peroxidation TNF-α expression levels PC12 cells treated lipopolysaccharide. In conclusion, our findings demonstrate efficacy bioinformatics networks expedite discovery previously unidentified food-derived active intervention.

Language: Английский

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Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer’s Disease

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 13

Published: Aug. 28, 2022

Alzheimer’s disease (AD) is one of the serious and progressive neurodegenerative disorders in elderly worldwide. Various genetic, environmental, lifestyle factors are associated with its pathogenesis that affect neuronal cells to degenerate over period time. AD characterized by cognitive dysfunctions, behavioural disability, psychological impairments due accumulation amyloid beta (Aβ) peptides neurofibrillary tangles (NFT). Several research reports have shown flavonoids polyphenolic compounds significantly improve functions inhibit or delay aggregation NFT formation AD. Current has uncovered dietary use flavonoid-rich food sources essentially increases intellectual abilities postpones hinders senescence cycle related problems including During pathogenesis, multiple signalling pathways involved target a single pathway may relieve symptoms but not provides permanent cure. Flavonoids communicate different adjust their activities, accordingly prompting valuable neuroprotective impacts. likewise hamper movement obsessive indications hindering apoptosis incited neurotoxic substances. In this short review, we briefly discussed about classification properties could be used as potential source for treatment also highlight structural features flavonoids, beneficial roles human health, significance plants well microbial production.

Language: Английский

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Neuroprotective Effect of Artichoke-Based Nanoformulation in Sporadic Alzheimer’s Disease Mouse Model: Focus on Antioxidant, Anti-Inflammatory, and Amyloidogenic Pathways

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(10), P. 1202 - 1202

Published: Sept. 28, 2022

The vast socio-economic impact of Alzheimer's disease (AD) has prompted the search for new neuroprotective agents with good tolerability and safety profile. With its outstanding role as antioxidant anti-inflammatory, alongside anti-acetylcholinesterase activity, artichoke can be implemented in a multi-targeted approach AD therapy. Moreover, agricultural wastes represent according to current United Nations Sustainable Development goals an opportunity produce medicinally valuable phenolic-rich extracts. In this context, UPLC-ESI-MS/MS phytochemical characterization bracts extract revealed presence mono- di-caffeoylquinic acids apigenin, luteolin, kaempferol O-glycosides remarkable total phenolics flavonoids contents. A broad spectrum was established vitro. Artichoke-loaded, chitosan-coated, solid lipid nanoparticles (SLNs) were prepared characterized their size, zeta potential, morphology, entrapment efficiency, release, ex vivo permeation showed suitable colloidal characteristics, controlled release profile, promising permeation, indicating possibly better physicochemical biopharmaceutical parameters than free extract. anti-Alzheimer potential SLNs assessed streptozotocin-induced sporadic Alzheimer mice. great improvement cognitive functions spatial memory recovery, addition marked reduction inflammatory biomarker TNF-α, β-amyloid, tau protein levels, observed. Significant efficacy dentate Gyrus sub-regions achieved mice treated significantly higher extent artichoke-loaded SLNs. results clarify strong botanical anti-AD drug will contribute altering future medicinal outlook previously regarded agro-industrial waste.

Language: Английский

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Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: May 4, 2022

Alzheimer’s disease (AD) is a chronic, complex neurodegenerative disorder mainly characterized by the irreversible loss of memory and cognitive functions. Different hypotheses have been proposed thus far to explain etiology this devastating disorder, including those centered on Amyloid-β (Aβ) peptide aggregation, Tau hyperphosphorylation, neuroinflammation oxidative stress. Nonetheless, therapeutic strategies conceived treat AD neurodegeneration proven unsuccessful, probably due use single-target drugs unable arrest progressive deterioration brain For reason, theoretical description has recently switched from over-emphasizing single deleterious process considering as result different pathogenic mechanisms their interplay. Moreover, much relevance conferred several comorbidities inducing insulin resistance energy hypometabolism, diabetes obesity. As consequence, interest currently accorded in treatment multi-target approach interfering with pathways at same time, life-style interventions aimed preventing modifiable risk-factors strictly associated aging. In context, phytochemical compounds are emerging an enormous source draw search for agents completing or assisting traditional pharmacological medicine. Intriguingly, many plant-derived efficacy counteracting processes such Aβ neuroinflammation, stress resistance. Many also overcome limitations some promising phytochemicals related poor pharmacokinetic profiles, nanotechnology synthetic routes. Considering potential natural medicine, aim present review therefore highlight most belonging two major classes, polyphenols monoterpenes, report main findings about action relating pathogenesis.

Language: Английский

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The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

Phytomedicine, Journal Year: 2023, Volume and Issue: 112, P. 154686 - 154686

Published: Jan. 31, 2023

Language: Английский

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Application of Luteolin in Neoplasms and Nonneoplastic Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15995 - 15995

Published: Nov. 6, 2023

Researchers are amazed at the multitude of biological effects 3′,4′,5,7-tetrahydroxyflavone, more commonly known as luteolin, it simultaneously has antioxidant and pro-oxidant, well antimicrobial, anti-inflammatory, cancer-preventive, properties. The anticancer properties luteolin constitute a mosaic pathways due to which this flavonoid influences cancer cells. Not only is able induce apoptosis inhibit cell proliferation, but also suppresses angiogenesis metastasis. Moreover, succeeds in sensitization therapeutically induced cytotoxicity. Nevertheless, apart from its promising role chemoprevention, exhibits numerous potential utilizations patients with conditions other than neoplasms, include inflammatory skin diseases, diabetes mellitus, COVID-19. This review aims present multidimensionality luteolin’s impact on both neoplastic nonneoplastic diseases. When comes we intend describe complexity molecular mechanisms that underlay effectiveness, prove usefulness integrating therapy via analysis recent research breast, colon, lung cancer. Regarding emphasize importance researching areas such diabetology, virology, dermatology summarizes most important discoveries those fields regarding application.

Language: Английский

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Gut microbiota-host lipid crosstalk in Alzheimer’s disease: implications for disease progression and therapeutics

Molecular Neurodegeneration, Journal Year: 2024, Volume and Issue: 19(1)

Published: April 16, 2024

Abstract Trillions of intestinal bacteria in the human body undergo dynamic transformations response to physiological and pathological changes. Alterations their composition metabolites collectively contribute progression Alzheimer’s disease. The role gut microbiota disease is diverse complex, evidence suggests lipid metabolism may be one potential pathways. However, mechanisms that mediate pathology remain unclear, necessitating further investigation for clarification. This review highlights current understanding how disrupts discusses implications these discoveries guiding strategies prevention or treatment based on existing data.

Language: Английский

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