Unveiling Novel Targets in Lung Tumors for Enhanced Radiotherapy Efficacy: A Comprehensive Review DOI Open Access

Faris Anad Muhammad,

Ayat Hussein Adhab,

Morug Salih Mahdi

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 23, 2025

ABSTRACT Radiotherapy is a cornerstone of lung cancer management, though its efficacy frequently undermined by intrinsic and acquired radioresistance. This review examines the complexity tumors, highlighting their potential as reservoir novel targets for radiosensitization. Ionizing radiation (IR) primarily exerts effects through oxidative damage DNA double‐strand breaks (DSBs). Lung cells, however, develop mutations that enhance response (DDR) suppress cell death pathways. Additionally, interactions between tumor cells microenvironment (TME) components—including immune stromal molecular mediators such cytokines, chemokines, growth factors—contribute to resistance against IR. Understanding these intricate relationships reveals improve radiotherapy outcomes. Promising include DDR pathways, immunosuppressive molecules, hypoxia, proangiogenic mediators, other key signaling discusses emerging strategies, combining with immunomodulators, hypoxia inhibitors, DDR‐targeting agents, innovative approaches. By offering comprehensive analysis TME, this underscores opportunities effectiveness targeted radiosensitization strategies.

Language: Английский

Resveratrol in Cancer Therapy: From Stimulation of Genomic Stability to Adjuvant Cancer Therapy: A Comprehensive Review DOI

Peyman Amini,

Reza Moazamiyanfar,

Mohammad Sedigh Dakkali

et al.

Current Topics in Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 23(8), P. 629 - 648

Published: Oct. 14, 2022

Abstract: Cancer therapy through anticancer drugs and radiotherapy is associated with several side effects as well tumor resistance to therapy. The genotoxic of chemotherapy may lead genomic instability increased risk second cancers. Furthermore, some responses in the induce exhaustion antitumor immunity increase cancer cells Administration low-toxicity adjuvants protect normal tissues improve efficacy an intriguing strategy. Several studies have focused on natural-derived agents for improving efficiency radiotherapy, chemotherapy, novel such immunotherapy targeted Resveratrol a naturally occurring substance antioxidant, cardioprotective, anti-diabetes, properties. has been demonstrated modulate mitigate tissue toxicity following exposure various ionizing radiation. Compelling data suggest that resveratrol be appealing adjuvant combination modalities. Although natural form limitations, low absorption intestine bioavailability, experiments using certain carriers, nanoparticles, can therapeutic preclinical studies. This review highlights useful Consequently, we describe how from instability. In addition, mechanisms by which exerts its are addressed. Moreover, outcomes other reviewed.

Language: Английский

Citations

33
Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanisms DOI Open Access
Masoud Moslehi,

Sepideh Rezaei,

Pourya Talebzadeh

et al.

Clinical and Experimental Pharmacology and Physiology, Journal Year: 2022, Volume and Issue: 50(1), P. 3 - 18

Published: Sept. 16, 2022

The incidence of cancer has been growing worldwide. Better survival rates following the administration novel drugs and new combination therapies may concomitantly cause concern regarding long-term adverse effects therapy, for example, second primary malignancies. Moreover, overcoming tumour resistance to anticancer agents long considered as a critical challenge in research. Some low toxic adjuvants such herb-derived molecules be interest chemoprevention malignancies therapy. Apigenin is plant-derived molecule with attractive properties chemoprevention, instance, promising anti-tumour effects, which make it desirable adjuvant reduce genomic instability risks among normal tissues. improve efficiency modalities. This paper aims review various apigenin both tissues In addition, we explain how have ability protect usual cells against genotoxic repercussions radiotherapy chemotherapy. Furthermore, inhibitory on tumours will discussed.

Language: Английский

Citations

31
Curcumin in the treatment of urological cancers: Therapeutic targets, challenges and prospects DOI
Mehrdad Hashemi, Sepideh Mirzaei,

Maryamsadat Barati

et al.

Life Sciences, Journal Year: 2022, Volume and Issue: 309, P. 120984 - 120984

Published: Sept. 20, 2022

Language: Английский

Citations

29
Targeting anticancer immunity in oral cancer: Drugs, products, and nanoparticles DOI

Liling Qin,

Jianan Wu

Environmental Research, Journal Year: 2023, Volume and Issue: 239, P. 116751 - 116751

Published: July 27, 2023

Language: Английский

Citations

20
Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways DOI

Peyman Amini,

Reza Moazamiyanfar,

Mohammad Sedigh Dakkali

et al.

Mini-Reviews in Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 23(14), P. 1461 - 1478

Published: Jan. 20, 2023

Induction of cell death and inhibition proliferation in cancer have been set as some the main goals anti-tumor therapy. Cancer resistance leads to less efficient therapy, consequently, higher doses anticancer drugs, which may eventually increase risk serious side effects normal tissues. Apigenin, a nature-derived herbal agent, has shown properties several types cancer, can induce directly and/or amplify induction through other modalities. Although mechanism apigenin order is apoptosis, pathways, such autophagic death, senescence, anoikis, necroptosis, ferroptosis, reported be induced by apigenin. It seems that enhances apoptosis inducing immunity tumor suppressor genes, like p53 PTEN, also inhibiting STAT3 NF-κB signaling pathways. Furthermore, it ferroptosis endogenous ROS generation. Stimulation production well downregulation drug-resistance mediators, mechanisms necroptosis. each type highly dependent on cancer. These modulatory actions enhance agents, ionizing radiation chemotherapy drugs. This review explains how at cellular molecular levels.

Language: Английский

Citations

18
Mechanisms of cancer cell death induction by triptolide DOI
Ali Hamid AbdulHussein, Muataz Mohammed Al‐Taee,

Zahra Abdul Radih

et al.

BioFactors, Journal Year: 2023, Volume and Issue: 49(4), P. 718 - 735

Published: March 6, 2023

Abstract Drug resistance is a hot topic issue in cancer research and therapy. Although therapy including radiotherapy anti‐cancer drugs can kill malignant cells within the tumor, develop wide range of mechanisms to resist toxic effects agents. Cancer may provide some oxidative stress escape from apoptosis attack by immune system. Furthermore, senescence, pyroptosis, ferroptosis, necroptosis, autophagic cell death modulating several critical genes. The development these leads also radiotherapy. Resistance increase mortality reduce survival following Thus, overcoming facilitate tumor elimination efficiency Natural‐derived molecules are intriguing agents that be suggested used as an adjuvant combination with other anticancer or sensitize at least side effects. This paper aims review potential triptolide for inducing various types cells. We induction different such apoptosis, death, necrosis administration triptolide. safety future perspectives its derivatives experimental human studies. make them effective adjuvants enhancing suppression

Language: Английский

Citations

15
The Combination of Bioavailable Concentrations of Curcumin and Resveratrol Shapes Immune Responses While Retaining the Ability to Reduce Cancer Cell Survival DOI Open Access
Chiara Focaccetti, Camilla Palumbo, Monica Benvenuto

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 232 - 232

Published: Dec. 23, 2023

The polyphenols Curcumin (CUR) and Resveratrol (RES) are widely described for their antitumoral effects. However, low bioavailability is a drawback use in therapy. aim of this study was to explore whether CUR RES, used at bioavailable concentration, could modulate immune responses while retaining antitumor activity determine RES effects on the peripheral blood mononuclear cells (PBMCs) tumor growth inhibition be improved by combination. We demonstrate that low-dose combination reduced survival cancer cell lines but had no effect viability PBMCs. Although following + treatment T lymphocytes showed an enhanced activated state, counteracted increased IFN-γ expression induced polyphenol IL-10 production regulatory cells. On other hand, combined NK through up- downregulation activating inhibitory receptors CD68 levels monocytes/macrophages. Overall, our results indicate doses differentially shapes activity, support combinations anticancer therapy suggest its possible application as adjuvant cell-based immunotherapies.

Language: Английский

Citations

15
Targeting the breast tumor microenvironment by plant-derived products and their nanoformulations DOI
Hongpeng Zhang, Yanshu Li

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 93, P. 105432 - 105432

Published: Feb. 5, 2024

Language: Английский

Citations

5
Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations DOI
Mohamed J. Saadh, Mohammed Ahmed Mustafa,

H. Malathi

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(8)

Published: July 13, 2024

Language: Английский

Citations

5
Regulation of dietary polyphenols on cancer cell pyroptosis and the tumor immune microenvironment DOI Creative Commons

xiaoxia huang,

Yao Wang, Wenhui Yang

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Aug. 25, 2022

Cancer is a major public health problem that threatens human life worldwide. In recent years, immunotherapy has made great progress in both clinical and laboratory research. But the high heterogeneity dynamics of tumors makes not suitable for all cancers. Dietary polyphenols have attracted researchers' attention due to their ability induce cancer cell pyroptosis regulate tumor immune microenvironment (TIME). This review expounds regulation dietary new forms on TIME. These include curcumin (CUR), resveratrol (RES), epigallocatechin gallate (EGCG), apigenin, triptolide (TPL), kaempferol, genistein moscatilin. New refer synthetic analogs nano-delivery, liposomes. Studies past decade are included. The result shows breast cells, liver oral squamous carcinoma other cells through different pathways. Moreover, exhibit potential TIME by modulating programmed death protein 1(PD-1)/programmed death-ligand 1 (PD-L1) axis, enhancing antitumor weakening function activity immunosuppressive targeting tumor-associated macrophages (TAMs) reduce infiltration promote polarization toward M1 type. also used with radiotherapy chemotherapy improve immunity shape beneficial conclusion, TIME, providing ideas safer cures.

Language: Английский

Citations

21