Microfluidic Gut-on-A-Chip Systems for Drug Development: Recent Advances and Future Prospects DOI
Xueqi Wang,

Yuzhuo Zhu,

Zhaoming Cheng

et al.

Published: Jan. 1, 2024

The gut is a vital organ that central to the absorption and metabolic processing of orally administered drugs. While there have been many models developed with goal studying drugs in gut, these fail adequately recapitulate diverse, complex gastrointestinal microenvironment. recent emergence microfluidic organ-on-a-chip technologies has provided novel means modeling yielding radical new insights into structure mechanisms through which it shapes disease, key implications for biomedical developmental efforts. Such demonstrated exhibit greater cost-effectiveness, fewer ethical concerns, better ability address inter-species differences traditional animal context drug development. present review offers an overview developments reconstruction function vitro using gut-on-a-chip (GOC) systems, together discussion potential applications platforms development challenges future prospects associated this technology.

Language: Английский

Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques DOI Creative Commons
Hui Wang, Xiangyang Li, Pengcheng Shi

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101079 - 101079

Published: May 5, 2024

As a booming engineering technology, the microfluidic chip has been widely applied for replicating complexity of human intestinal micro-physiological ecosystems in vitro. Biosensors, 3D imaging, and multi-omics have to engineer more sophisticated barrier-on-chip platforms, allowing improved monitoring physiological processes enhancing performance. In this review, we report cutting-edge advances techniques establishment evaluation barrier platforms. We discuss different design principles microfabrication strategies gut models Further, comprehensively cover complex cell types (e.g., epithelium, organoids, endothelium, microbes, immune cells) controllable extracellular microenvironment parameters oxygen gradient, peristalsis, bioflow, gut-organ axis) used recapitulate main structural functional barriers. also present current multidisciplinary technologies indicators evaluating morphological structure integrity established Finally, highlight challenges future perspectives accelerating broader applications these platforms disease simulation, drug development, personalized medicine. Hence, review provides comprehensive guide development microfluidic-based

Language: Английский

Citations

9
Validation of a Caco-2 microfluidic Chip model for predicting intestinal absorption of BCS Class I-IV drugs DOI
Stephanie Zhang, Whitney S. Y. Ong, Natalia Subelzú

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 656, P. 124089 - 124089

Published: April 8, 2024

Language: Английский

Citations

5
Microfluidic organ-on-a-chip models for the gut–liver axis: from structural mimicry to functional insights DOI
Weifeng Hu, Yushen Wang,

Junlei Han

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review discusses advancements in organ-on-a-chip models, emphasizing gut, liver, and integrated gut–liver systems. It covers their applications disease modeling, toxicity testing, drug screening, as well future prospects.

Language: Английский

Citations

0
Standard: human intestine-on-a-chip DOI Creative Commons
Haitao Liu, Yaqing Wang, Xu Zhang

et al.

Cell Regeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: Aug. 5, 2024

Abstract Organs-on-chips are microphysiological systems that allow to replicate the key functions of human organs and accelerate innovation in life sciences including disease modeling, drug development, precision medicine. However, due lack standards their definition, structural design, cell source, model construction, functional validation, a wide range translational application organs-on-chips remains challenging. “Organs-on-chips: Intestine” is first group standard on intestine-on-a-chip China, jointly agreed released by experts from Chinese Society Biotechnology 29th April 2024. This specifies scope, terminology, definitions, technical requirements, detection methods, quality control building intestinal chip. The publication this will guide institutional establishment, acceptance execution proper practical protocols international standardization for applications.

Language: Английский

Citations

1
Emerging microfluidic gut-on-a-chip systems for drug development DOI
Xueqi Wang,

Yuzhuo Zhu,

Zhaoming Cheng

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

1
Microfluidic Gut-on-A-Chip Systems for Drug Development: Recent Advances and Future Prospects DOI
Xueqi Wang,

Yuzhuo Zhu,

Zhaoming Cheng

et al.

Published: Jan. 1, 2024

The gut is a vital organ that central to the absorption and metabolic processing of orally administered drugs. While there have been many models developed with goal studying drugs in gut, these fail adequately recapitulate diverse, complex gastrointestinal microenvironment. recent emergence microfluidic organ-on-a-chip technologies has provided novel means modeling yielding radical new insights into structure mechanisms through which it shapes disease, key implications for biomedical developmental efforts. Such demonstrated exhibit greater cost-effectiveness, fewer ethical concerns, better ability address inter-species differences traditional animal context drug development. present review offers an overview developments reconstruction function vitro using gut-on-a-chip (GOC) systems, together discussion potential applications platforms development challenges future prospects associated this technology.

Language: Английский

Citations

0