Biotechnology Journal, Journal Year: 2024, Volume and Issue: 19(10)

Published: Oct. 1, 2024

ABSTRACT Nanoparticles (NPs) have emerged as a promising solution for many biomedical applications. Although not all particles antimicrobial or regenerative properties, certain NPs show promise in enhancing wound healing by promoting tissue regeneration, reducing inflammation, and preventing infection. Integrating various can further enhance these effects. Herein, the zinc oxide (ZnO)‐MXene‐Ag nanocomposite was prepared, conjugation of its three components confirmed through scanning electron microscopy (SEM) energy dispersive X‐ray (EDX) mapping analysis. In vitro analysis using agar well diffusion technique demonstrated that ZnO‐MXene‐Ag exhibited high efficacy, significantly inhibiting Escherichia coli , Salmonella Candida albicans showing enhanced potency when combined with tetracycline, resulting 2.6‐fold increase against Staphylococcus 2.4‐fold Pseudomonas . The efficacy nanocomposite‐loaded carboxymethyl cellulose (CMC) gel on investigated varying concentrations (0, 1, 5, 10 mg/mL). Wound monitored over 21 days, results indicating wounds treated 1 mg/mL superior compared to control group (0 mg/mL), significant improvements noted from Day 3 onward. Conversely, higher (10 mg/mL) resulted reduced efficiency, particularly notable 15. conclusion, CMC is agent These findings highlight importance optimizing NP concentration maximize therapeutic benefits while minimizing potential cytotoxicity.

Language: Английский