ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
17(1), P. 547 - 559
Published: Dec. 30, 2024
Photoactivatable
gold
nanocarriers
are
transforming
antitumor
therapies
by
leveraging
their
distinctive
physicochemical
properties,
enabling
targeted
drug
delivery
and
enhanced
therapeutic
efficacy
in
cancer
treatment.
This
study
systematically
investigates
how
surface
topography
morphology
of
influence
loading
capacity,
light-to-heat
conversion
efficiency,
overall
performance
photo/chemotherapy.
We
synthesized
four
distinct
morphologies
nanoparticles:
porous
nanocups
(PAuNCs),
nanospheres
(PAuNSs),
solid
(SAuNCs),
(SAuNSs).
By
examining
these
morphologies,
we
isolated
the
effects
roughness,
porosity,
inner
cavity
structures
on
critical
parameters.
Our
findings
reveal
that
PAuNCs
exhibit
superior
capabilities
due
to
area
facilitating
greater
interaction
with
agents.
Whereas,
dissolution
kinetic
modeling
confirmed
porosity
contributes
improve
diffusion-controlled
release.
In
vitro
studies
HepG2
cells
demonstrated
markedly
improved
cellular
uptake,
resulting
a
dramatic
reduction
cell
viability
3%
notable
increase
apoptosis
(60.45%).
Under
near-infrared
(NIR)
irradiation,
effectively
induced
localized
hyperthermia
(46.7
°C)
significantly
inhibited
tumor
growth
an
vivo
mice
model
compared
alternative
nanogold
morphologies.
research
underscores
role
morphology,
cavitation
optimizing
enhancing
outcomes
photoactivatable
for
collaborative
photochemotherapy.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(25)
Published: March 16, 2024
The
immunosuppressive
tumor
microenvironment
(TME)
is
a
huge
hurdle
in
immunotherapy.
Sono-immunotherapy
new
treatment
modality
that
can
reverse
TME,
but
the
sonodynamic
effects
are
compromised
by
overexpressed
glutathione
(GSH)
and
hypoxia
TME.
Herein,
this
work
reports
sono-immunotherapy
strategy
using
Pd
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(28)
Published: May 20, 2024
Abstract
Single‐cell
multiomic
and
exosome
analyses
are
potent
tools
in
various
fields,
such
as
cancer
research,
immunology,
neuroscience,
microbiology,
drug
development.
They
facilitate
the
in‐depth
exploration
of
biological
systems,
providing
insights
into
disease
mechanisms
aiding
treatment.
isolation,
which
is
crucial
for
single‐cell
analysis,
ensures
reliable
cell
isolation
quality
control
further
downstream
analyses.
Microfluidic
chips
small
lightweight
systems
that
efficient
high‐throughput
real‐time
analysis
on‐
or
off‐chip.
Therefore,
most
current
technologies
based
on
microfluidic
technology.
This
review
offers
comprehensive
guidance
to
researchers
across
different
fields
selection
appropriate
chip
analysis.
describes
design
principles,
separation
mechanisms,
characteristics,
cellular
effects
available
isolation.
Moreover,
this
highlights
implications
using
technology
subsequent
analyses,
including
Finally,
challenges
future
prospects
outlined
multiplex
BMEMat,
Journal Year:
2024,
Volume and Issue:
2(3)
Published: April 15, 2024
Abstract
Advanced
drug
delivery
systems
are
widely
considered
to
be
powerful
approaches
for
treating
cancer
and
many
other
diseases
because
of
their
superior
ability
improve
pharmacokinetics,
promote
lesion‐targeted
efficacy,
and/or
reduce
the
toxic
effects
diverse
therapeutics.
Owing
unique
biomimetic
structure
lipid
bilayers
surrounding
aqueous
cavities,
liposomes
have
been
found
encapsulate
various
therapeutics,
ranging
from
small
molecules
with
different
hydrophobicities
biomacromolecules.
With
advent
surface
PEGylation,
stealth
excellent
in
vivo
long‐circulating
behaviors
generated,
thus
these
extensively
explored
development
liposomal
drugs
greatly
improved
pharmacokinetic
by
functioning
as
vehicles.
Inspired
successes
clinical
practice,
recently
utilized
main
building
scaffold
or
coating
layers
nanoparticulate
formulations,
which
coined
nonclassical
nanoscale
(NDDSs)
this
review,
enable
rational
design
next‐generation
nanomedicine.
Therefore,
after
overviewing
latest
progress
conventional
liposome‐based
nanomedicine,
we
will
introduce
NDDSs
well
innovative
treatment
strategies.
We
subsequently
provide
a
critical
perspective
on
future
new
nanomedicines
based
rationally
designed
NDDSs.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(24)
Published: April 6, 2024
Abstract
Customizable
and
number‐tunable
enzyme
delivery
nanocarriers
will
be
useful
in
tumor
therapy.
Herein,
a
phage
vehicle,
T4‐Lox‐DNA‐Fe
(TLDF),
which
adeptly
modulates
numbers
using
display
technology
to
remodel
the
microenvironment
(TME)
is
presented.
Regarding
demand
for
lactic
acid
tumors,
each
engineered
720
lactate
oxidase
(Lox),
contributing
depletion
of
restructure
tumor's
energy
metabolism.
The
vehicle
incorporated
dextran
iron
(Fe)
with
Fenton
reaction
capabilities.
H
2
O
generated
through
Lox
catalytic
reaction,
amplifying
supply
iron‐based
chemodynamic
therapy
(CDT).
Drawing
inspiration
from
erythropoietin
(EPO)
biosynthetic
process,
an
EPO
enhancer
constructed
impart
EPO‐Keap1
plasmid
(DNA)
hypoxia‐activated
functionality,
disrupting
redox
homeostasis
TME.
consumes
local
oxygen,
positive
feedback
between
promotes
expression
kelch
ECH
Associated
Protein
1
(Keap1).
Consequently,
downregulation
antioxidant
transcription
factor
Nrf2,
synergy
CDT,
amplifies
oxidative
killing
effect,
leading
suppression
up
78%.
This
study
seamlessly
integrates
adaptable
T4
vehicles
bio‐intelligent
plasmids,
presenting
promising
approach
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Coacervates
have
garnered
significant
attention
as
potential
drug
carriers.
However,
the
instability
resulting
from
their
intrinsic
membrane-free
nature
restricts
application
of
coacervates
in
delivery.
Herein,
engineering
poly(ethylene
glycol)
nanoparticles
(PEG
NPs)
is
reported
using
composed
PEG
and
polyphenols
templates,
where
subsequently
cross-linked
based
on
different
chemistries
(e.g.,
thiol-disulfide
exchange,
click
chemistry,
Schiff
base
reaction).
The
assembly
strategy
avoids
template
removal
process
resultant
NPs
exhibit
excellent
stability
physiological
environment
compared
to
coacervates.
presence
enables
loading
various
cargos
including
metal
ions
(i.e.,
Ru,
Gd,
Mn,
Fe)
molecules
doxorubicin),
which
demonstrates
promise
magnetic
resonance
imaging
combinational
tumor
therapy.
This
work
provides
a
promising
promote
development
coacervate-derived
delivery
system
for
biomedical
applications.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
Cell
membrane
coating
has
emerged
as
a
promising
strategy
for
the
surface
modification
of
biomaterials
with
biological
membranes,
serving
cloak
that
can
carry
more
functions.
The
cloaked
inherit
diverse
intrinsic
biofunctions
derived
from
different
cell
sources,
including
enhanced
biocompatibility,
immunity
evasion,
specific
targeting
capacity,
and
immune
regulation
regenerative
microenvironment.
characteristics
biomimicry
biointerfacing
have
demonstrated
versatility
technology
on
variety
biomaterials,
thus,
furthering
research
into
wide
range
biomedical
applications
clinical
translation.
Here,
preparation
coatings
is
emphasized,
sizes
coated
nanoscale
to
macroscale
well
engineering
strategies
introduce
additional
are
summarized.
Subsequently,
utilization
biomimetic
membrane-cloaked
in
discussed,
drug
delivery,
imaging
phototherapy,
cancer
immunotherapy,
anti-infection
detoxification,
implant
modification.
In
conclusion,
latest
advancements
preclinical
studies,
along
multiple
benefits
membrane-coated
nanoparticles
(NPs)
systems,
elucidated.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: May 1, 2025
Despite
the
success
in
exploring
various
aspects
of
origination
and
therapeutic
strategies,
cancer
has
remained
one
most
dreadful
metabolic
disorders
due
to
failure
eradicate
tumors
comprehensively
frequent
recurrence
because
acquired
resistance
drugs.
Recently,
several
advancements
have
been
evidenced
fabrication
smart
nanocarriers
encapsulated
with
multiple
components.
Several
reasons
for
nanoencapsulation
include
enhancement
bioavailability
drugs,
precise
targetability
reduce
adverse
effects
on
normal
cells,
ability
enable
controlled
drug
release
rates
at
tumor
sites.
In
addition,
these
protect
cargo
from
deactivation,
responsively
delivering
it
based
physiological
or
pathological
characteristics
tumors.
this
review,
we
present
approaches
therapy,
including
organic
materials,
inorganic
components,
their
composites,
as
well
biomembrane-based
strategies.
These
along
practical
applications
potential
treatment,
are
discussed
depth,
highlighting
advantages
disadvantages,
aiming
reveal
ultimate
prospects
enhancing
delivery
efficiency
targeted
therapy.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
Immune
checkpoint
inhibitors
have
demonstrated
remarkable
efficacy
across
various
cancer
types.
However,
immune‐related
adverse
events
(irAEs)
pose
a
significant
challenge
in
immunotherapy,
particularly
the
associated
pneumonia
as
primary
reaction,
which
can
lead
to
irreversible
pulmonary
fibrosis.
Additionally,
monotherapy
with
programmed
death
ligand
(PD‐L1)
has
shown
limited
effectiveness.
Therefore,
improve
response
rate
of
immunotherapy
and
reduce
fibrosis,
this
study
designed
prepared
an
intelligent
nanodrug
based
on
dendritic
mesoporous
silica
nanoparticles
(DMSNs)
loaded
sono‐sensitive
agent
protoporphyrin
IX
(PpIX).
reactive
oxygen
species
(ROS)
sensitive
linker
is
used
attach
immunotherapeutic
drug
PD‐L1
inhibitor
(aPD‐L1)
DMSNs
via
covalent
bonds.
The
external
ultrasound
(US)
activates
PpIX
generate
ROS,
breaks
release
aPD‐L1
induce
sonodynamic
therapy
(SDT)
immunotherapy.
This
sono‐immnotherapy
approach
excellent
outcomes
tumor
inhibition,
eliciting
immune
responses,
reducing
Overall,
offers
new,
efficient,
safe
method
for
breast
treatment,
expands
application
