Whey protein - chitosans complexes as sustainable and value-added biomaterials for wound healing. DOI Creative Commons
Daiana Ianev, Barbara Vigani, Caterina Valentino

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: unknown, P. 100643 - 100643

Published: Dec. 1, 2024

Language: Английский

Cordyceps polysaccharide improves polycystic ovary syndrome by inhibiting gut-derived LPS/TLR4 pathway to attenuates insulin resistance DOI
Huiwen Zhang, Ziwen He,

Yigong Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135844 - 135844

Published: Sept. 1, 2024

Language: Английский

Citations

3
A pH‐Responsive, Surface Charge‐Switchable Nanosystem with Enhanced Biofilm Penetration for Synergistic Photodynamic and Antibiotic Therapy of Diabetic Wounds DOI Open Access

Zhencheng Sun,

Minghui Xiao,

Shuyi Lv

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

Abstract Chronic wounds, particularly those associated with diabetes, pose a significant clinical challenge due to their tendency develop biofilms that resist conventional antibiotic treatments. To address this issue, novel therapeutic strategy utilizing pH‐responsive nanoparticles loaded aggregation‐induced emission photosensitizers and natural saturated fatty acids (AIE/LA@HMONs−PyB) for effective biofilm penetration disruption is proposed. Under physiological conditions, AIE/LA@HMONs−PyB are negatively charged. Upon accumulation at infected sites, however, the pyridine betaine group on surface of enables rapid protonation charge reversal in acidic microenvironment, thereby enhancing ability penetrate biofilm. light irradiation, these generate reactive oxygen species effectively disrupt structure. This process synergistic action ciprofloxacin lower concentration, achieving an exceptional vitro antibacterial efficiency 99.99% against methicillin‐resistant Staphylococcus aureus ( S. ) biofilms. Furthermore, vivo diabetic wound model, therapy accelerates healing by reducing inflammation, promoting angiogenesis, collagen regeneration. The enhanced significantly improves efficacy combined approach, offering great promise advancing chronic patient outcomes.

Language: Английский

Citations

3
Innovative anticancer nanocomposites from Corchorus olitorius mucilage/chitosan/selenium nanoparticles DOI
Mohsen M. El‐Sherbiny, Mohamed E. El‐Hefnawy, Ahmed A. Tayel

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137320 - 137320

Published: Nov. 6, 2024

Language: Английский

Citations

2
Novel antimicrobial packaging film with finger wrinkles structures based on egg white and chitosan coating for fruit preservation DOI

Chen Li,

Fayong Li, Ke Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137888 - 137888

Published: Nov. 1, 2024

Language: Английский

Citations

2
A straightforward strategy to modulate ROS generation of AIE photosensitizers for type-I PDT DOI

Zhencheng Sun,

Jiaxin Wang,

Minghui Xiao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 155782 - 155782

Published: Sept. 1, 2024

Language: Английский

Citations

1
Recent advances toward emerging nanozymes with aggregation-induced emission DOI Creative Commons
Xin Li, Zhao Wang, Jing He

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

AIE luminogens (AIEgens) are a class of unique fluorescent molecules that exhibit significantly enhanced luminescence properties and excellent photostability in the aggregated state. Recently, it has been found some AIEgens can produce reactive oxygen species, which means they may have potential enzyme-like activities thus termed "AIEzymes". Consequently, discovery design novel with emerged as new exciting research direction. Additionally, enhance catalytic efficiency traditional nanozymes by direct combination, thereby endowing multifunctionality. In this regard, aggregation-induced emission (AIE) properties, represents win-win integration, not only take full advantage low cost stability nanozymes, but also incorporate biocompatibility fluorescence AIEgens. These synergistic compounds bring about opportunities for various applications, making AIEzymes interest biomedical research, food analysis, environmental monitoring, especially imaging-guided diagnostics. This review will provide an overview latest strategies achievements rational preparation AIEzymes, well current trends, future challenges prospective solutions. We expect work encourage motivate more people to study explore further promote their applications fields.

Language: Английский

Citations

1
TEAD transcription factor family emerges as a promising therapeutic target for oral squamous cell carcinoma DOI Creative Commons
Shuang Wang, Dan Shao, Xiaoyan Gao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 4, 2024

The treatment of oral squamous cell carcinoma (OSCC) remains a significant difficulty, as there has been no improvement in survival rates over the past fifty years. Hence, exploration and confirmation new dependable targets biomarkers is imperative for OSCC therapy. TEAD transcription factors are crucial integrating coordinating multiple signaling pathways that essential embryonic development, organ formation, tissue homeostasis. In addition, by attaching to coactivators, modifies expression genes such Cyr61, Myc, connective growth factor, hence facilitating tumor progression. Therefore, regarded an effective predictive biomarker due its connection with clinical parameters several malignant tumors, including OSCC. efficacy existing drugs specifically target demonstrated encouraging outcomes, indicating potential optimal treatment. This review provides overview current targeted therapy strategies highlighting mechanism involvement oncogenic pathways. Finally, feasibility utilizing innovative approach address applications were analyzed discussed.

Language: Английский

Citations

0
A review on structure, bioactivity, mechanism, structure-activity relationship and application of anti-breast cancer polysaccharides DOI
Xiaoyin Wang,

Ao-Qiu Chen,

Jing Huang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137043 - 137043

Published: Oct. 1, 2024

Language: Английский

Citations

0
The Second Near-Infrared (NIR-II) Window Excitable/Emissive Organic/Polymeric Fluorescent Molecules for Bioimaging Application DOI Creative Commons
Guannan Liu, Chenguang Wang, Geyu Lu

et al.

Journal of Innovative Optical Health Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

The fluorescence imaging (FLI) in the second near-infrared window (NIR-II, 1000–1700[Formula: see text]nm) has attracted considerable attention past decade. In contrast to conventional NIR-I excitation (808[Formula: text]nm/980[Formula: text]nm), FLI with NIR-II (1064[Formula: text]nm/other wavelength beyond 1000[Formula: can afford deeper tissue penetration depth high clarity due merits of suppressed photon scattering and diminished autofluorescence. this review, we have summarized excitable/emissive organic/polymeric fluorophores recently developed. characteristics these such as chemical structures photophysical properties also been critically discussed. Furthermore, latest development noninvasive vivo was highlighted. ideal results emphasized importance enabling deep high-resolution imaging. Finally, a perspective on challenges prospects We expected review will be served source inspiration for researchers, stimulating creation novel excitable fostering bioimaging applications.

Language: Английский

Citations

0
Whey protein - chitosans complexes as sustainable and value-added biomaterials for wound healing. DOI Creative Commons
Daiana Ianev, Barbara Vigani, Caterina Valentino

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: unknown, P. 100643 - 100643

Published: Dec. 1, 2024

Language: Английский

Citations

0