Navigating the Brain: Harnessing Endogenous Cellular Hitchhiking for Targeting Neoplastic and Neuroinflammatory Diseases

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101040 - 101040

Published: Feb. 1, 2025

Language: Английский

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Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibitor mitigate Aβ oligomer-induced neurotoxicity in Alzheimer’s disease

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 6, 2025

Antioxidant enzyme therapy shows promise for treating Alzheimer's disease (AD), but significant challenges remain in achieving effective blood-brain barrier (BBB) penetration and sustained therapeutic effects. We developed a novel neutrophil membrane (NM)-coated cerium-doped Prussian blue biomimetic nanozyme (NM@PB-Ce) that demonstrates outstanding enzymatic properties targeted efficacy. Extensive physicochemical characterization using transmission electron microscopy, X-ray photoelectron spectroscopy, dynamic light scattering confirmed the successful synthesis of uniform nanoparticles (~ 142 nm) with preserved protein functionality. In vitro studies utilizing SH-SY5Y neuroblastoma cells revealed NM@PB-Ce effectively scavenged reactive oxygen species through multiple enzyme-mimetic activities (catalase, superoxide dismutase, peroxidase). The significantly suppressed NLRP3 inflammasome activation subsequent pyroptosis, reducing inflammatory markers (IL-1β, IL-18) while attenuating Aβ aggregation. Using sophisticated co-culture BBB model real-time vivo fluorescence imaging, we demonstrated NM@PB-Ce's ability to traverse accumulate specifically AD-affected regions. an Aβ1-42 oligomer-induced AD mouse model, systematic administration (320 μg/mL, 0.01 mL/g/day 14 days) improved cognitive performance across behavioral paradigms, including Morris water maze, Y-maze, open field tests. Molecular histological analyses decreased neuroinflammation (GFAP, Iba-1) hippocampus, reduced levels NLRP3, caspase-1, phosphorylated tau (demonstrated by Western blot ELISA), enhanced dendritic spine density (visualized Golgi staining). This comprehensive study establishes as promising platform treatment, providing both mechanistic insights into its mode action robust evidence efficacy targeting decline.

Language: Английский

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Evolution of nMOFs in photodynamic therapy: from porphyrins to chlorins and bacteriochlorins for better efficacy

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Photodynamic therapy (PDT) has gained significant attention due to its non-invasive nature, low cost, and ease of operation. Nanoscale metal-organic frameworks (nMOFs) incorporating porphyrins, chlorins, bacteriochlorins have emerged as one the most prominent photoactive materials for tumor PDT. These nMOFs could enhance water solubility, stability loading efficiency photosensitizers (PSs). Their highly ordered porous structure facilitates O2 diffusion enhances generation 1O2 from hydrophobic bacteriochlorins, thereby improving their efficacy phototherapy. This review provides insights into PDT effects derived bacteriochlorins. It overviews design strategies, types reactive oxygen species (ROS), ROS efficiency, unique biological processes involved in inhibiting cell proliferation, focusing on mechanism by which molecular leads enhanced photochemical properties. Finally, highlights new possibilities offered bacteriochlorins-based PDT, emphasizing how optimized can further improve bioapplication porphyrin derivatives represented PSs. With ongoing research technological advancements, we anticipate that this will garner increased scientific researchers toward porphyrin-based nMOFs, elevating potential a approach treatment malignant tumors.

Language: Английский

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Metal-phenolic nanozyme as a ferroptosis inhibitor for alleviating cisplatin-induced acute kidney injury

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Cisplatin-induced acute kidney injury (AKI) is primarily caused by oxidative stress from reactive oxygen species (ROS) accumulation. Developing ROS scavengers presents promising opportunities for preventing and treating this condition targeting mechanisms. This study involves the fabrication of a metal-polyphenol self-assembled nanozyme (Fe@Ba) designed to inhibit ferroptosis through synergistic catalytic actions antioxidant properties. The constructed using coordination-driven nanoprecipitation techniques. Its performance evaluated in vitro MTEC cells vivo within an AKI model, with assessments activities, depletion efficacy, effects, anti-ferroptotic Fe@Ba demonstrates significant catalase (CAT) superoxide dismutase (SOD)-like activities upon internalization cells, effectively reducing high levels model. Baicalein (Ba), traditional Chinese medicine component nanozyme, exhibits strong properties, inhibits lipid peroxidation (LPO), upregulates reductive glutathione (GSH), promotes peroxidase 4 (GPX4) expression, thereby inhibiting ferroptosis. Fluorescence imaging confirms effective renal accumulation Cy5.5-labeled nanozyme. In experiments show reduces inflammation significantly enhances survival rates models. validates concept self-assembling nanozymes treatment offers new insights into nanomedicine applications. nanozyme's ability counteract inflammation-related damage multiple mechanisms highlights its therapeutic potential. successful integration components nanotechnology represents innovative approach addressing cisplatin-induced AKI, suggesting broader applications stress-related diseases.

Language: Английский

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Application of metal polyphenol nanonetworks in phototherapy

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 539, P. 216743 - 216743

Published: April 23, 2025

Language: Английский

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Ultrasmall platinum single-atom enzyme alleviates oxidative stress and macrophage polarization induced by acute kidney ischemia–reperfusion injury through inhibition of cell death storm

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 27, 2025

Acute kidney injury (AKI), characterized by a rapid decline in renal function, is associated with impaired mitochondrial function and excessive reactive oxygen species (ROS). Therefore, the exploration of ROS scavengers provides promising new opportunities for prevention treatment AKI mitigating oxidative stress. Here, we construct an ultrasmall platinum single-atom enzyme (Pt/SAE) multiple antioxidant activities to protect against acute ischemia-reperfusion (I/R) injury. Pt/SAE not only mimics superoxide dismutase catalase convert anion into water oxygen, but also exhibits impressive hydroxyl radical scavenging capacity, thereby reducing pro-inflammatory macrophage levels preventing inflammation. Furthermore, reduces accumulation Z-form DNA, which excessively accumulates following I/R damage, thus decreasing its interaction Z-DNA binding protein 1, consequently progression PANoptosis Additionally, downregulation induced suppresses lipid peroxidation, return ferroptosis I/R. Both vitro vivo experiments confirm that effectively mitigates inflammatory cell infiltration promotes shift polarization from M1-like M2-like subtype. This study information development novel SAEs as viable method AKI.

Language: Английский

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Engineering charge density in s-Block potassium single-atom nanozyme for amplified ferroptosis in glioblastoma therapy

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101889 - 101889

Published: May 1, 2025

Language: Английский

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