Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(7), P. 2161 - 2169

Published: March 7, 2024

Abstract Trauma-related intrusive memories (TR-IMs) possess unique phenomenological properties that contribute to adverse post-traumatic outcomes, positioning them as critical intervention targets. However, transdiagnostic treatments for TR-IMs are scarce, their underlying mechanisms have been investigated separate from properties. Extant models of more general episodic memory highlight dynamic hippocampal-cortical interactions vary along the anterior-posterior axis hippocampus (HPC) support different cognitive-affective and sensory-perceptual features memory. Extending this work into TR-IMs, we conducted a study eighty-four trauma-exposed adults who completed daily ecological momentary assessments TR-IM followed by resting-state functional magnetic resonance imaging (rs-fMRI). Spatiotemporal dynamics anterior posterior hippocampal (a/pHPC)-cortical networks were assessed using co-activation pattern analysis investigate associations with TR-IMs. Emotional intensity was inversely associated frequency persistence an aHPC-default mode network pattern. Conversely, sensory frequent HPC cortices ventral attention network, reliving in “here-and-now” persistent pHPC visual cortex. Notably, no found between HPC-cortical conventional symptom measures, including or retrospective recall, underscoring utility identifying neural substrates. These findings provide novel insights correlates development individualized, pervasive, difficult-to-treat symptom.

Language: Английский

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Brain dynamics reflecting an intra-network brain state are associated with increased post-traumatic stress symptoms in the early aftermath of trauma

Nature Mental Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

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Posterior cingulate cortex targeted real‐time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default‐mode network in PTSD

Brain and Behavior, Journal Year: 2023, Volume and Issue: 13(3)

Published: Feb. 15, 2023

Abstract Background Alterations within large‐scale brain networks—namely, the default mode (DMN) and salience networks (SN)—are present among individuals with posttraumatic stress disorder (PTSD). Previous real‐time functional magnetic resonance imaging (fMRI) electroencephalography neurofeedback studies suggest that regulating posterior cingulate cortex (PCC; primary hub of DMN) activity may reduce PTSD symptoms recalibrate altered network dynamics. However, PCC connectivity to DMN SN during PCC‐targeted fMRI remains unexamined help elucidate neurophysiological mechanisms through which these symptom improvements occur. Methods Using a trauma/emotion provocation paradigm, we investigated psychophysiological interactions over single session ( n = 14) healthy control 15) participants. We compared between regulate (in participants downregulated activity) view did not exert regulatory control) conditions across whole‐brain as well in priori specified regions‐of‐interest. Results During conditions, only group showed significant anterior (dmPFC, vmPFC) (posterior insula) regions, whereas both groups displayed other areas (precuneus/cuneus). Additionally, controls, significantly greater (amygdala) conditions. Moreover, linear regression analyses revealed regions was positively correlated psychiatric all Conclusion In summary, observations provide emerging evidence neural underlying PTSD. This supports use means by PTSD‐associated alterations SN, together, facilitate improved emotion regulation abilities

Language: Английский

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Circulating PACAP levels are associated with increased amygdala-default mode network resting-state connectivity in posttraumatic stress disorder

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 48(8), P. 1245 - 1254

Published: May 9, 2023

The pituitary adenylate cyclase-activating polypeptide (PACAP) system is implicated in posttraumatic stress disorder (PTSD) and related amygdala-mediated arousal threat reactivity. PTSD characterized by increased amygdala reactivity to and, more recently, aberrant intrinsic connectivity of the with large-scale resting state networks, specifically default mode network (DMN). While influence PACAP on has been described, its association remains unknown. To fill this gap, we examined functional resting-state magnetic resonance imaging (fMRI) eighty-nine trauma-exposed adults (69 female) screened for symptoms examine between blood-borne (circulating) levels amygdala-DMN connectivity. Higher circulating were associated posterior DMN regions, including cingulate cortex/precuneus (PCC/Precun) left angular gyrus (lANG). Consistent prior work, effect was seen female, but not male, participants centromedial, basolateral, subregions amygdala. Clinical analyses linked amygdala-PCC/Precun anxious symptoms, exaggerated startle response. Taken together, our findings converge previously demonstrated effects activity PTSD-related processes offer novel evidence an patterns PTSD. Moreover, these data provide preliminary motivate future work ascertaining sex- subregion-specificity effects. Such may enable mechanistic insights into neural circuit dysfunction how confers risk through a disruption dynamics.

Language: Английский

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Neural correlates and plasticity of explicit emotion regulation following the experience of trauma

Frontiers in Behavioral Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 13, 2025

Experiencing trauma or other adverse life events is highly prevalent and poses a significant risk for the development of mental disorders. Understanding underlying mechanisms neural processes involved in processing crucial both prevention targeting symptoms. Especially, difficulties emotion regulation emerge as one key mechanism implicated conditions such post-traumatic stress disorder (PTSD) following traumatic experiences. However, correlates explicit among individuals who have undergone not received much attention. basis dysregulated could reveal important details about how interferes with emotional systems, informing more specific intervention approaches. Therefore, this mini review summarizes current research, identifies relevant gaps literature challenges future studies. Specifically, it provides an overview dysregulation associated strategies reappraisal suppression. Finally, highlights promising findings from studies regulation, trauma-focused exposure therapy neurofeedback, indicating plasticity Hereby, aims to bridge gap between fundamental research directions translational research.

Language: Английский

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Amygdala hyperactivity in PTSD: disentangling predisposing from consequential factors in a prospective longitudinal design

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Getting stress-related disorders under control: the untapped potential of neurofeedback

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(10), P. 766 - 776

Published: Sept. 10, 2024

Language: Английский

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A tale of two targets: examining the differential effects of posterior cingulate cortex- and amygdala-targeted fMRI-neurofeedback in a PTSD pilot study

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Nov. 29, 2023

Introduction Real-time fMRI-based neurofeedback (rt-fMRI-NFB) is a non-invasive technology that enables individuals to self-regulate brain activity linked neuropsychiatric symptoms, including those associated with post-traumatic stress disorder (PTSD). Selecting the target region for neurofeedback-mediated regulation primarily informed by neurobiological characteristics of participant population. There strong link between PTSD symptoms and multiple functional disruptions in brain, hyperactivity within both amygdala posterior cingulate cortex (PCC) during trauma-related processing. As such, previous rt-fMRI-NFB studies have focused on these two regions when training regulate neural activity. However, differential effects selection PTSD-related clinical outcomes not previously been investigated. Methods Here, we compared whole-brain activation changes participants ( n = 28) trained downregulate either 14) or PCC while viewing personalized trauma words. Results For as group, observed decreased several implicated psychopathology – namely, bilateral cuneus/precuneus/primary visual cortex, left superior parietal lobule, occipital pole, right temporal gyrus/temporoparietal junction (TPJ) downregulation using rt-fMRI-NFB. Conversely, there were no unique (i.e., over above group) decreases Importantly, was significantly improved whereas reduced reliving distress course this single session. In pilot analysis, did detect significant between-group differences state neurofeedback. critical control, groups differ their ability respective regions. This indicates subsequent results can be attributed terms neurophysiological function, rather than result group regulatory success. Conclusion study, differentially simultaneous PTSD-associated novel analysis may guide researchers choosing future help establish efficacy specific targets PTSD. A multi-session trial directly compares warranted.

Language: Английский

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Mindfulness-based real-time fMRI neurofeedback: a randomized controlled trial to optimize dosing for depressed adolescents

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 17, 2023

Adolescence is characterized by a heightened vulnerability for Major Depressive Disorder (MDD) onset, and currently, treatments are only effective roughly half of adolescents with MDD. Accordingly, novel interventions urgently needed. This study aims to establish mindfulness-based real-time fMRI neurofeedback (mbNF) as non-invasive approach downregulate the default mode network (DMN) in order decrease ruminatory processes depressive symptoms.

Language: Английский

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The Clinical Impact of Real-Time fMRI Neurofeedback on Emotion Regulation: A Systematic Review

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(7), P. 700 - 700

Published: July 12, 2024

Emotion dysregulation has long been considered a key symptom in multiple psychiatric disorders. Difficulties emotion regulation have associated with neural fronto-limbic circuits. Real-time fMRI-based neurofeedback (rt-fMRI-NFB) become increasingly popular as potential treatment for emotional disorders, it is able to directly target the impaired However, clinical impact of these rt-fMRI-NFB protocols populations still largely unknown. Here we provide comprehensive overview primary studies from 2010 2023 that used regulation. We assessed 41 out 4001 original methodological quality and risk bias synthesised concerning frequency significant rt-fMRI-NFB-related effects on behaviour level. Successful modulation brain activity was reported between 25 50 percent study samples, while samples were more diverse than healthy samples. Interestingly, behavioural improvement over 75 showed improvements 0 percent. Concerning subsamples, observed up 100 major depressive disorder (MDD) post-traumatic stress (PTSD) Substance use benefits ranging Neural appeared be less frequent improvements: most outcomes ranged MDD substance PTSD. Using individualised regions interest (ROIs) training resulted solely based amygdala or prefrontal cortex. While studies, heterogeneous, which limits current evaluation putative dysregulation.

Language: Английский

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