Progress in molecular biology and translational science, Journal Year: 2023, Volume and Issue: unknown, P. 159 - 169
Published: Jan. 1, 2023
Language: Английский
Canadian Journal of Infectious Diseases and Medical Microbiology, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 10
Published: Dec. 10, 2022
Colistin resistance is a globalized sensible issue because it has been considered drug of the last-line resort to treat drug-resistant bacterial infections. The product mobilized colistin (mcr) gene and its variants are significant causes resistance, which emerging due frequent use in veterinary, these genes circulate among community. Apart from mcr genes, some other intrinsic proteins also involved resistance. Researchers focus on most advanced genomics (whole genome sequencing), proteomics, bioinformatics approaches explore question To combat researchers developed various strategies such as development newer drugs, repurposing existing combinatorial treatment by with nano-based approach, photodynamic therapy, CRISPRi-based strategy, phage-based strategy. In this timeline review, we have discussed management developing countries.
Language: Английский
Citations
42
Antibiotics, Journal Year: 2023, Volume and Issue: 12(6), P. 1012 - 1012
Published: June 5, 2023
The discovery of antibiotics has revolutionized medicine and changed medical practice, enabling successful fighting infection. However, quickly after the start antibiotic era, therapeutics for infectious diseases started having limitations due to development antimicrobial resistance. Since pipeline largely slowed down, with few new compounds being produced in last decades most them belonging already-existing classes, ways treat pathogens that are resistant is becoming an urgent need. To end, bacteriophages (phages), which already used some countries agriculture, aquaculture, food safety, wastewater plant treatments, could be also clinical practice against bacterial pathogens. Their one century ago was followed by studies showed optimistic results were limited, however, notable obstacles. rise during next left phage research inactive status. In decades, on phages have shown encouraging animals. Hence, further humans needed confirm their potential effective safe treatment cases where there or no other viable therapeutic options. This study reviews biology applications non-medical uses a narrative manner.
Language: Английский
Citations
23
Materials Advances, Journal Year: 2024, Volume and Issue: 5(3), P. 986 - 1016
Published: Jan. 1, 2024
The bioengineering of phages to display ligands leads specific targeting, reduced toxicity, enhanced cellular uptake an incorporated drug/gene and, ultimately, increased therapeutic efficacy.
Language: Английский
Citations
12
Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(2)
Published: Aug. 3, 2022
Antibiotic resistance ranks among the top threats to humanity. Due frequent use of antibiotics, society is facing a high prevalence multidrug resistant pathogens, which have managed evolve mechanisms that help them evade last line therapeutics. An alternative antibiotics could involve bacteriophages (phages), are natural predators bacterial cells. In earlier times, phages were implemented as therapeutic agents for century but mainly replaced with and considering menace antimicrobial resistance, it might again become interest due increasing threat antibiotic pathogens. The current understanding phage biology clustered regularly interspaced short palindromic repeats (CRISPR) assisted genome engineering techniques facilitated generate variants unique values. this review, we briefly explain strategies engineer bacteriophages. Next, highlight literature supporting CRISPR-Cas9-assisted effective more specific targeting Lastly, discuss either increase fitness, specificity, or lytic ability control an infection.
Language: Английский
Citations
36
Microbial Pathogenesis, Journal Year: 2023, Volume and Issue: 186, P. 106467 - 106467
Published: Nov. 28, 2023
Language: Английский
Citations
13
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Oct. 7, 2024
Biofilms are complex microbial communities in which planktonic and dormant bacteria enveloped extracellular polymeric substances (EPS) such as exopolysaccharides, proteins, lipids, DNA. These multicellular structures present resistance to conventional antimicrobial treatments, including antibiotics. The formation of biofilms raises considerable concern healthcare settings, can exacerbate infections patients compromise the integrity medical devices employed during treatment. Similarly, certain bacterial species contribute bulking, foaming, biofilm development water environments wastewater treatment plants, reservoirs, aquaculture facilities. Additionally, food production facilities provide ideal conditions for establishing biofilms, serve reservoirs foodborne pathogens. Efforts combat antibiotic involve exploring various strategies, bacteriophage therapy. Research has been conducted on effects phages their individual proteins assess potential removal. However, challenges persist, prompting examination refined approaches drug-phage combination therapies, phage cocktails, genetically modified clinical applications. This review aims highlight progress regarding bacteriophage-based eradication different settings.
Language: Английский
Citations
5
BioDrugs, Journal Year: 2024, Volume and Issue: 38(3), P. 387 - 404
Published: April 11, 2024
Language: Английский
Citations
4
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(3)
Published: April 1, 2024
Over the years, administration of antibiotics for purpose addressing bacterial infections has become increasingly challenging due to increased prevalence antimicrobial resistance exhibited by various strains bacteria. Multidrug-resistant (MDR) species are rising unavailability novel antibiotics, leading higher mortality rates. With these conditions, there is a need alternatives in which phage therapy made promising results. Phage-derived endolysins, cocktails, and bioengineered phages effective have properties against MDR extensively drug-resistant strains. Despite these, it been observed that can give activity more than one species. Thus, cocktail resistant provides broad spectrum treatment magnitude effectivity, many folds antibiotics. Many commercially available endolysins such as Staphefekt SA.100, Exebacase (CF-301), N-Rephasin®SAL200 used biofilm penetration treating plant diseases. The role CMP1 endolysin transgenic tomato plants preventing Clavibacter michiganensis infection effectiveness protecting Atlantic salmon from vibriosis reported. Furthermore, phage-derived therapy, TSPphg exogenous treatment, aid disrupting cell walls, lysis. As animals aquaculture slaughterhouses highly susceptible infections, instead help treat poultry animals, preserve them, facilitate disease-free trade. Using cocktails enhances providing target specificity. Research currently being conducted on clinical trials confirm efficacy engineered humans. Although obtaining commercial approval may be time-consuming, will beneficial postantibiotic era. This review an overview significance potential alternative combating its application fields emphasizes importance safeguarding ensuring efficacy.
Language: Английский
Citations
4
Microchemical Journal, Journal Year: 2024, Volume and Issue: 203, P. 110931 - 110931
Published: June 6, 2024
Language: Английский
Citations
4
Current Microbiology, Journal Year: 2024, Volume and Issue: 81(10)
Published: Sept. 6, 2024
Language: Английский
Citations
4