Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 248, P. 154657 - 154657
Published: July 1, 2023
Language: Английский
Cancer Communications, Journal Year: 2022, Volume and Issue: 42(2), P. 117 - 140
Published: Jan. 12, 2022
Abstract With the development of proteomics and epigenetics, a large number RNA‐binding proteins (RBPs) have been discovered in recent years, interaction between long non‐coding RNAs (lncRNAs) RBPs has also received increasing attention. It is extremely important to conduct in‐depth research on lncRNA‐RBP network, especially context its role occurrence cancer. Increasing evidence demonstrated that interactions play vital cancer progression; therefore, targeting these could provide new insights for drug discovery. In this review, we discussed how lncRNAs can interact with regulate their localization, modification, stability, activity effects transport, transcription, localization lncRNAs. Moreover, explored regulation influence lncRNAs, RBPs, downstream pathways are related development, such as N6‐methyladenosine (m6A) modification addition, network regulates cell phenotypes, proliferation, apoptosis, metastasis, resistance, immunity, tumor environment, metabolism. Furthermore, summarized therapeutic strategies target network. Although treatments still experimental stage various theories processes being studied, believe may ideas treatment.
Language: Английский
Citations
174
Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 325 - 345
Published: May 25, 2022
Understanding the complex and specific roles played by non-coding RNAs (ncRNAs), which comprise bulk of genome, is important for understanding virtually every hallmark cancer. This large group molecules plays pivotal in key regulatory mechanisms various cellular processes. Regulatory mechanisms, mediated long RNA (lncRNA) RNA-binding protein (RBP) interactions, are well documented several types Their effects enabled through networks affecting lncRNA RBP stability, metabolism including N6-methyladenosine (m6A) alternative splicing, subcellular localization, numerous other involved In this review, we discuss reciprocal interplay between lncRNAs RBPs their involvement epigenetic regulation via histone modifications, as role resistance to cancer therapy. Other aspects structural domains, provide a deeper knowledge on how interact exert biological functions. addition, current state-of-the-art knowledge, facilitated machine deep learning approaches, unravels such interactions better details further enhance our field, potential harness RNA-based therapeutics an treatment modality discussed.
Language: Английский
Citations
95
Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)
Published: Jan. 9, 2024
Language: Английский
Citations
19
Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)
Published: Sept. 23, 2023
Gastric cancer (GC) is one of the most prevalent malignant tumors digestive system. As a hallmark cancer, energy-related metabolic reprogramming manipulated by multiple factors, including long non-coding RNAs (lncRNAs). Notably, lncRNA CCAT1 has been identified as crucial regulator in tumor progression. Nevertheless, precise molecular mechanisms underlying involvement GC remain unclear. Gain- and loss-of-function experiments were performed to evaluate roles tumorigenesis glycolysis GC. Bioinformatics analyses mechanistic experiments, such mass spectrometry (MS), RNA-pulldown, RNA immunoprecipitation (RIP), employed reveal potential interacting protein elucidate regulatory mechanism glycolysis. Moreover, nude mice xenograft assay was used effect on cells vivo. In this study, we that expression significantly elevated tissues plasma exosomes patients, well cell lines. Functional showed knockdown resulted substantial decrease proliferation, migration invasion both vitro vivo through decreasing glycolytic enzymes rate. Conversely, overexpression exhibited contrasting effects. Mechanistically, interacted with PTBP1 effectively maintained its stability inhibiting ubiquitin-mediated degradation process. critical splicing factor, facilitated transition from PKM1 PKM2, thereby augmenting activity ultimately fostering progression Our findings demonstrate plays significant role promoting migration, PTBP1/PKM2/glycolysis pathway, thus suggesting CCAT1's biomarker therapeutic target for
Language: Английский
Citations
24
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: March 16, 2024
Abstract Background Long noncoding RNAs (lncRNAs) have emerged as key players in tumorigenesis and tumour progression. However, the biological functions potential mechanisms of lncRNAs colorectal cancer (CRC) are unclear. Methods The novel lncRNA POU6F2-AS1 was identified through bioinformatics analysis, its expression CRC patients verified via qRT–PCR FISH. In vitro vivo experiments, such BODIPY staining, Oil Red O triglyceride (TAG) assays, liquid chromatography mass spectrometry (LC-MS) were subsequently performed with specimens cells to determine clinical significance, functional roles POU6F2-AS1. Biotinylated RNA pull-down, RIP, Me-RIP, ChIP, patient-derived organoid (PDO) culture assays confirm underlying mechanism Results is markedly upregulated associated adverse clinicopathological features poor overall survival patients. Functionally, promotes growth lipogenesis both vivo. Mechanistically, METTL3-induced m 6 A modification involved upregulation Furthermore, could tether YBX1 FASN promoter induce transcriptional activation, thus facilitating cells. Conclusions Our data revealed that plays a critical role fatty acid metabolism might provide promising biomarker therapeutic target for CRC.
Language: Английский
Citations
15
Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)
Published: April 10, 2024
Long noncoding RNAs (lncRNAs) play essential roles in the tumorigenesis of gastric cancer. However, influence lncRNA methylation on cancer stem cells (GCSCs) remains unclear.
Language: Английский
Citations
10
Cancer Letters, Journal Year: 2024, Volume and Issue: 596, P. 217004 - 217004
Published: June 4, 2024
Language: Английский
Citations
10
Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(8)
Published: Aug. 28, 2024
Long non-coding RNAs (lncRNAs) play an important role in breast cancer progression, but the function of lncRNAs regulating tumor-associated macrophages (TAMs) remains unclear. As carriers lncRNAs, exosomes as mediators communication between cells and tumor microenvironment. In this study, we found that lncRNA HAGLROS was highly expressed tissues plasma exosomes, its high expression related to poor prognosis patients. Functionally, cell-derived exosomal promotes cell proliferation, migration, epithelial-mesenchymal transition (EMT) process angiogenesis by inducing TAM/M2 polarization. Mechanistically, competitively binds miR-135-3p prevent degradation target gene COL10A1. Collectively, these results indicated HAGLROS/miR-135b-3p/COL10A1 axis promoted revealed interactive mechanism TAMs, suggesting may be a potential biomarker therapeutic for cancer.
Language: Английский
Citations
9
Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)
Published: Sept. 26, 2024
Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.
Language: Английский
Citations
9
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 131, P. 111876 - 111876
Published: March 16, 2024
Language: Английский
Citations
8