8q24 derived ZNF252P promotes tumorigenesis by driving phase separation to activate c-Myc mediated feedback loop DOI Creative Commons
Tianyu Qu, Chang Zhang, Xiyi Lu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 26, 2025

As a well-known cancer risk region, the 8q24 locus is frequently amplified in variety of solid tumors. Here we identify pseudogene-derived oncogenic lncRNA, ZNF252P, which upregulated types by copy number gain as well c-Myc-mediated transcriptional activation. Mechanistically, ZNF252P binds and drives "phase separation" HNRNPK ILF3 protein nucleus cytoplasm, respectively, to transcriptionally posttranscriptionally activate c-Myc, thus forming c-Myc/ZNF252P/c-Myc positive feedback loop. These findings expand understanding relationship between genomic instability region tumorigenesis clarify regulatory mechanism involved transcription posttranscription from perspective RNA-mediated nuclear cytoplasmic phase separation, sheds light on dialogue with driver oncogene c-Myc. The pivotal axis ZNF252P/c-Myc has potential promising biomarker therapeutic target development. most human cancers. Here, authors discover that located 8q24, promotes regulating loop through separation ILF3.

Language: Английский

Targeting and engineering long non-coding RNAs for cancer therapy DOI
Michela Coan, Simon Haefliger,

Samir Ounzain

et al.

Nature Reviews Genetics, Journal Year: 2024, Volume and Issue: 25(8), P. 578 - 595

Published: Feb. 29, 2024

Language: Английский

Citations

65
Application of artificial intelligence for improving early detection and prediction of therapeutic outcomes for gastric cancer in the era of precision oncology DOI
Zhe Wang, Yang Liu, Xing Niu

et al.

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 93, P. 83 - 96

Published: April 27, 2023

Language: Английский

Citations

45
Cancer Epigenetics: An Overview DOI Open Access
Félix Recillas‐Targa

Archives of Medical Research, Journal Year: 2022, Volume and Issue: 53(8), P. 732 - 740

Published: Nov. 18, 2022

Language: Английский

Citations

62
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m6A-dependent recognition of Nrf2 mRNA mediated by SND1 DOI Creative Commons
Jianglin Zheng, Qing Zhang,

Zhen Zhao

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)

Published: May 19, 2023

Abstract Background Ferroptosis has been linked to tumor progression and resistance antineoplastic therapy. Long noncoding RNA (lncRNA) exerts a regulatory role in various biological processes of cells, while the function molecular mechanism lncRNA ferroptosis are yet be clarified glioma. Methods Both gain-of-function loss-of-function experiments were employed investigate effects SNAI3-AS1 on tumorigenesis susceptibility glioma vitro vivo. Bioinformatics analysis, Bisulfite sequencing PCR, pull-down, RIP, MeRIP dual-luciferase reporter assay performed explore low expression downstream Results We found that inducer erastin downregulates by increasing DNA methylation level promoter. functions as suppressor Importantly, enhances anti-tumor activity promoting both Mechanistically, competitively binds SND1 perturbs m 6 A-dependent recognition Nrf2 mRNA 3’UTR SND1, thereby reducing stability Nrf2. Rescue confirmed overexpression silence can rescue gain- ferroptotic phenotypes SNAI3-AS1, respectively. Conclusions Our findings elucidate effect detailed SNAI3-AS1/SND1/Nrf2 signalling axis ferroptosis, provide theoretical support for inducing improve treatment.

Language: Английский

Citations

32
Towards artificial intelligence to multi-omics characterization of tumor heterogeneity in esophageal cancer DOI
Junyu Li, Lin Li,

Peimeng You

et al.

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 91, P. 35 - 49

Published: March 1, 2023

Language: Английский

Citations

29
Long noncoding RNA ABHD11-AS1 interacts with SART3 and regulates CD44 RNA alternative splicing to promote lung carcinogenesis DOI Creative Commons
Po‐Shun Wang, Zulong Liu, Osama Sweef

et al.

Environment International, Journal Year: 2024, Volume and Issue: 185, P. 108494 - 108494

Published: Feb. 10, 2024

Hexavalent chromium [Cr(VI)] is a common environmental pollutant and chronic exposure to Cr(VI) causes lung cancer in humans, however, the mechanism of carcinogenesis has not been well understood. Lung leading cause cancer-related death, although mechanisms how develops progresses have poorly While long non-coding RNAs (lncRNAs) are found abnormally expressed cancer, dysregulated lncRNAs contribute remains largely unknown. The goal this study investigate Cr(VI)-induced focusing on role lncRNA ABHD11 antisense RNA 1 (tail tail) (ABHD11-AS1). It was that ABHD11-AS1 expression levels up-regulated exposure-transformed human bronchial epithelial cells, chronically Cr(VI)-exposed mouse tissues, cells as well. Bioinformatics analysis revealed adenocarcinomas (LUADs) tissues associated with worse overall survival LUAD patients but squamous cell carcinomas. further determined up-regulation plays an important exposure-induced malignant transformation tumorigenesis, stemness cells. Mechanistically, it directly binds SART3 (spliceosome factor 3, U4/U6 recycling protein). interaction promotes USP15 (ubiquitin specific peptidase 15) nuclear localization. Nuclear localized interacts pre-mRNA processing 19 (PRPF19) increase CD44 alternative splicing activating β-catenin enhancing stemness. Together, these findings indicate regulates promote carcinogenesis.

Language: Английский

Citations

11
CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects DOI Creative Commons
Lei Tang, Xin Chen, Jianquan Hou

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 4, 2025

CXCL14 is a highly conserved chemokine expressed in various cell types, playing crucial roles both physiological and pathological processes, including immune regulation tumorigenesis. Recently, the role of tumors has attracted considerable attention. However, previous pan-cancer studies have reported inconsistencies regarding effects on tumors, particularly concerning its expression levels tumor tissues influence phenotypes cancer cells. This variability believed to stem from context-dependent nature CXCL14, as different sources secretion within distinct microenvironments may mediate diverse biological effects. Such phenomena also been observed prostate research. Despite foundational understanding cancer, there remains lack comprehensive reviews summarizing specific this systematically analyzing reasons behind complex Therefore, article aims discuss microenvironment explore future research directions potential applications.

Language: Английский

Citations

1
RNA binding protein Pumilio2 promotes chemoresistance of pancreatic cancer via focal adhesion pathway and interacting with transcription factor EGR1 DOI Creative Commons

Zhao Bangbo,

Cheng Qin,

Li Zeru

et al.

Cellular and Molecular Life Sciences, Journal Year: 2025, Volume and Issue: 82(1)

Published: Feb. 17, 2025

Pancreatic cancer (PCa) has insidious onset, high malignancy and poor prognosis. Gemcitabine (GEM) is one of the first-line chemotherapy drugs for PCa. However, GEM resistance always been a bottleneck problem leading to recurrence death PCa patients. RNA-binding proteins (RBPs) are important that regulate transportation, splicing, stability translation RNA. Abnormal expression RBPs often lead series abnormal accumulation or degradation downstream RNA resulting in various diseases. In our study, we utilized RIP seq, RIP-qPCR, vitro vivo experiments found pumilio2 (PUM2) was PCa, promoted by regulating mRNA integrin Alpha 3 (ITGA3) other genes focal adhesion pathway, there positive feedback regulation between PUM2 transcription factor early growth response gene 1 (EGR1), binding 3′UTR region EGR1 mRNA, promoter gene. The discovery EGR1/PUM2/ITGA3 axis provided solid experimental basis selection regiments patients exploration combined regimens reverse future.

Language: Английский

Citations

1
LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2 DOI Creative Commons
Jie Wang, Zhiwei He, Xinyuan Liu

et al.

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(8)

Published: Aug. 18, 2022

Abstract Recently, long non-coding RNAs (lncRNA) have been proven to regulate pancreatic cancer (PC) progression. We aimed explore the pathogenesis of LINC00941 in PC regarding protein binding. By using PCR analysis, we found that was overexpressed tissues and higher patients with liver metastasis than without metastasis. In addition, high expression associated a poor prognosis. Functional experiments mice models were respectively used evaluate cell proliferation migration vitro vivo. The results suggested overexpression promoted Subsequently, RNA pull-down, mass spectrometry (MS), RNA-binding immunoprecipitation (RIP) performed identify -interacting proteins. ANXA2 potential protein. Nucleotides 500–1390 could bind Annexin 1 domain ANXA2. -mediated malignant phenotype reversed by depletion. Co-immunoprecipitation (Co-IP) followed MS conducted determine interacting LINC00941. illustrated NEDD4L, an E3 ligase involved ubiquitin-mediated degradation, bound its degradation. Mechanically, functioned as decoy suppressed degradation enclosing binds NEDD4L. Eventually, upregulated activated FAK/AKT signaling, increasing This study indicates promotes binding potentiating stability, leading activation signaling. Our data demonstrate may serve novel target for prognosis therapy.

Language: Английский

Citations

38
Non-Coding RNAs Modulating Estrogen Signaling and Response to Endocrine Therapy in Breast Cancer DOI Open Access
Oliver Treeck, Silke Haerteis, Olaf Ortmann

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(6), P. 1632 - 1632

Published: March 7, 2023

The largest part of human DNA is transcribed into RNA that does not code for proteins. These non-coding RNAs (ncRNAs) are key regulators protein-coding gene expression and have been shown to play important roles in health, disease therapy response. Today, endocrine ERα-positive breast cancer (BC) a successful treatment approach, but resistance this major clinical problem. Therefore, deeper understanding mechanisms overcome resistance. An increasing amount evidence demonstrate ncRNAs affect the response therapy. Thus, considered versatile biomarkers predict or monitor In review article, we intend give summary update on effects microRNAs (miRNAs), long (lncRNAs) circular (circRNAs) estrogen signaling BC cells, pathway being target therapy, their role For purpose, reviewed articles these topics listed PubMed database. Finally, provide an assessment regarding use ncRNA types, particularly circulating forms, as predictive potential targets

Language: Английский

Citations

15