Cited by The cross-talk between LncRNAs and JAK-STAT signaling pathway in cancer

Exploring the roles and molecular mechanisms of RNA binding proteins in the sorting of noncoding RNAs into exosomes during tumor progression DOI

Ting Wang, Hui Zhang

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 65, P. 105 - 123

Published: Nov. 27, 2023

RNA binding proteins (RBPs) play a role in sorting non-coding RNAs (ncRNAs) into exosomes. These ncRNAs, carried by exosomes, are involved regulating various aspects of tumor progression, including metastasis, angiogenesis, control the microenvironment, and drug resistance. Recent studies have emphasized importance RBP-ncRNA-exosome mechanism regulation. Aim review: This comprehensive review aims to explore its influence on development. By understanding this intricate provides novel insights regulation may lead innovative treatment strategies future. Key scientific concepts The discusses formation exosomes complex relationships among RBPs, is shown affect biology, multidrug resistance, immunosuppressive progression. Tumor development relies transmission information between cells, with RBPs selectively mediating ncRNAs through mechanisms, which turn carry regulate RBPs. also an overview potential therapeutic strategies, such as targeted discovery genetic engineering for modifying hold great promise improving cancer treatment.

Language: Английский

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Molecular mechanism of lncRNAs in pathogenesis and diagnosis of auto-immune diseases, with a special focus on lncRNA-based therapeutic approaches DOI

Amirreza Mehmandar‐Oskuie,

Kasra Jahankhani,

Arman Rostamlou

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 336, P. 122322 - 122322

Published: Dec. 1, 2023

Language: Английский

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eIF3d: A driver of noncanonical cap–dependent translation of specific mRNAs and a trigger of biological/pathological processes DOI

Shijie Ma,

Jingyuan Liu, Jian‐Ting Zhang

et al.

Journal of Biological Chemistry, Journal Year: 2023, Volume and Issue: 299(5), P. 104658 - 104658

Published: March 29, 2023

Language: Английский

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Novel insights into mutual regulation between N6-methyladenosine modification and LncRNAs in tumors DOI

Nan Zhang, Yifei Sun, Zongqin Mei

et al.

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: June 26, 2023

Abstract N 6 -methyladenosine (m A), one of the most common RNA methylation modifications, has emerged in recent years as a new layer regulatory mechanism controlling gene expression eukaryotes. As reversible epigenetic modification, m A not only occurs on mRNAs but also Long non-coding RNAs (LncRNAs). we all known, despite LncRNAs cannot encode proteins, they affect proteins by interacting with or miRNAs, thus playing important roles occurrence and development variety tumors. Up to now, it been widely accepted that modification affects fate corresponding LncRNAs. Interestingly, levels functions modifications are mediated through affecting methyltransferases (METTL3, METTL14, WTAP, METTL16, etc.), demethylases (FTO, ALKBH5) methyl-binding (YTHDFs, YTHDCs, IGF2BPs, HNRNPs, which collectively referred “m regulators”. In this review, summarized mutual regulation mechanisms between cancer progression, metastasis, invasion drug resistance. detail, focus specific is demethylases, involves LncRNA first part. And section two intensively displays mediation via changing proteins. At last part, described interaction effects during various tumor development.

Language: Английский

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The cross-talk between LncRNAs and JAK-STAT signaling pathway in cancer DOI

Ahmed Hjazi, Rasha Fadhel Obaid,

Sally Saad Ali

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 248, P. 154657 - 154657

Published: July 1, 2023

Language: Английский

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