Published: Jan. 1, 2024
Language: Английский
Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102270 - 102270
Published: April 15, 2024
Language: Английский
Citations
14
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 5, 2024
Abstract Sonodynamic therapy (SDT) represents a promising, noninvasive, and precise treatment modality for tumors, demonstrating significant potential in clinical applications. However, the efficiency of sonosensitizers generating reactive oxygen species (ROS) is often limited by rapid electron‐hole recombination. In this study, BiF 3 @BiOI synthesized via co‐precipitation method, followed in‐situ reduction to decorate it with Pt nanoparticles, resulting @BiOI@Pt‐PVP (BBP) nanocomposite enhancing SDT efficacy. The formation heterojunction enhances charge separation ability. decoration nanoparticles narrows bandgap alters band positions Fermi level BBP, which can effectively mitigate recombination pairs facilitate cascade reaction ROS, thereby improving ROS generation ultrasound excitation. Additionally, bismuth ions BBP generated holes consume glutathione, exacerbating cellular oxidative damage, triggering PANoptosis ferroptosis. Furthermore, demonstrate peroxidase‐like activity, catalyzing endogenous hydrogen peroxide oxygen. These functions are helpful against tumors alleviating hypoxic conditions, reshaping microenvironment, modulating immune cell infiltration capacity, efficacy immunotherapy. dual strategy forming heterojunctions sensitization noble metals sono‐catalytic therapy‐induced activation tumor treatment.
Language: Английский
Citations
9
Cancer Medicine, Journal Year: 2023, Volume and Issue: 12(24), P. 22206 - 22223
Published: Dec. 1, 2023
Abstract Background PANoptosis is a novel form of programmed cell death (PCD) found in 2019 that regulated by the PANoptosome. combines essential features pyroptosis, apoptosis, and necroptosis, forming “death triangle” cells. While necroptosis have been extensively studied for their roles human inflammatory diseases many other clinical conditions, historically they were considered as independent processes. However, emerging evidence indicates these PCDs exhibit cross talk interactions, resulting development concept PANoptosis. Methods In this review, we offer concise summary fundamental mechanisms necroptosis. We subsequently introduce notion detail assembly mechanism PANoptosome complex which responsible inducing death. also describe some regulatory networks Results now has associated with various including cancer. Although exact function each tumor not fully understood, it represents prospective avenue cancer therapy, offering promise advancements therapy. Conclusions future, in‐depth study will continue to help us understanding processes underlying provide scientific support research.
Language: Английский
Citations
14
Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: 407, P. 111379 - 111379
Published: Jan. 8, 2025
Language: Английский
Citations
0
Breast Cancer Research and Treatment, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 28, 2025
Language: Английский
Citations
0
IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 6, 2025
This chapter explores how to regulate programmed cell death and its relevance in cancer therapy. It points the need of investigate mechanisms death, like apoptosis, necroptosis, and, more recently, exposed ferroptosis, while creating approaches for treatment malignant diseases. In spite progress field targeted therapies, is still a main cause due incapability cells undergo apoptosis. The highlights significance adopting complex that encompass multiple types occurring within both tumor microenvironment. Of note are functions oncogenes suppressor genes regulation cellular processes, specific role apoptosis formation process, possibility increase neoplastic cells. There metastasis critical such as TP53 gene, along with presence an over expression anti-apoptotic proteins. Examples this would include Bcl-2 IAPs, which protect against stimuli required death. immunotherapy combination therapies described emerging strategies enhance efficacy treatments. document also deals problem resistance induction necessity further clinical studies new therapeutic agents practice. summary, it diversity biology paradigm shift achieve
Language: Английский
Citations
0
International Journal of Genomics, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Background: Osteosarcoma (OS) is a highly aggressive bone malignancy prevalent in children and adolescents, characterized by poor prognosis limited therapeutic options. The tumor microenvironment (TME) cell death mechanisms such as PANoptosis—comprising pyroptosis, apoptosis, necroptosis—play critical roles progression immune evasion. This study aimed at exploring the PANoptosis landscape OS using single‐cell RNA sequencing (scRNA‐seq) developing robust prognostic model machine learning algorithms. Methods: Single‐cell data for were obtained from GEO database (GSE162454), bulk transcriptome sourced TARGET databases. Data integration, dimensionality reduction, clustering performed UMAP t‐SNE. PANoptosis‐related genes identified, their expression profiles used to score categorize cells into PANoptosis‐high PANoptosis‐low groups. A comprehensive was constructed 101 algorithms, including CoxBoost, predict patient outcomes. model’s performance validated across multiple cohorts, its association with mutation TME evaluated. Results: scRNA‐seq analysis revealed 14 distinct clusters within OS, significant activation observed cancer‐associated fibroblasts (CAFs), myeloid cells, osteoblasts, osteoclasts. Differentially expressed between groups communication showed enhanced interaction patterns group. CoxBoost model, selected exhibited stable effectively stratifying patients high‐risk low‐risk group displayed worse survival outcomes, higher frequencies, infiltration patterns, correlating poorer increased purity. Conclusion: provides novel insights presents risk stratification. integration of approaches enhances our understanding heterogeneity impact on prognosis, offering potential avenues targeted strategies. Further validation clinical settings warranted confirm utility guiding personalized treatment patients.
Language: Английский
Citations
0
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 5499 - 5517
Published: April 1, 2025
To identify the molecular signature of differentially expressed genes (DEGs) associated with PANoptosis in idiopathic pulmonary fibrosis (IPF) and to interpret their immune landscape cellular distribution characteristics. We acquired two IPF datasets from Gene Expression Omnibus (GEO) database PANoptosis-related DGEs (PAN-DEGs), initially identifying thirty PAN-DEGs. Utilizing machine learning algorithms, we established a five-gene comprising IGF1, GPX3, GADD45β, SMAD7, TIMP3, each demonstrating robust diagnostic performance. The expression these hub was subsequently validated using third GEO dataset bleomycin-induced model. Immune infiltration analysis revealed close association various cells, single-cell RNA sequencing indicated significant changes diverse cell types, particularly endothelial cells fibroblasts. identified gene IPF, providing insights into potential distribution. Further research is necessary elucidate biological functions mechanisms pathogenesis IPF.
Language: Английский
Citations
0
Interdisciplinary cancer research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123241 - 123241
Published: Nov. 1, 2024
Language: Английский
Citations
1