Effects of p-coumaric acid on Probiotic Properties of Lactobacillus acidophilus LA-5 and Lacticaseibacillus rhamnosus GG DOI Open Access

Buse Nur Derebasi,

Sena Davran Bulut,

Büşra Aksoy Erden

et al.

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 9, 2023

p-coumaric acid (p-CA) is one of the most abundant phenolic compounds in nature and human diet. Probiotic bacteria are microorganisms conferring health benefits on host when administered adequate amounts. The synbiotic interaction these two contents, found gastrointestinal tract, effect this intestines not known. Thus, study aimed to investigate relationship between p-CA Lactobacillus acidophilus LA-5 (LA-5), Lacticaseibacillus rhamnosus GG (LGG). They were grown presence different concentrations effects probiotic properties, as well vitro AChE BChE activities examined. Results indicated did negatively affect bacterial growth, but increased auto-aggregation both probiotics. While co-aggregation LGG against Escherichia coli, it decreased Staphylococcus aureus. Probiotics with more resistant pepsin. resistance bile salt, LGG. combinations efficiently suppressed inhibition (%) 11.31-68.06 13.47-65.14, respectively. Furthermore, surface analysis was conducted using FTIR LGG, changes cell components analyzed. results, recorded range 4000-600 cm⁻¹ resolution 4 cm⁻¹, demonstrated that significantly affected only phosphate/CH ratio for bacteria. These results indicate addition growth may enhance properties

Language: Английский

Marine natural products DOI Creative Commons
Anthony R. Carroll, Brent R. Copp, Tanja Grkovic

et al.

Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A comprehensive review of 1220 new MNPs including a novel sex inducing pheromone from the diatom Seminavis robusta .

Language: Английский

Citations

2
Novel composite structures based on cobalt phthalocyanine/graphene oxide: Identification of potential drug candidates to treat Alzheimer’s disease and diabetes DOI
Armağan Günsel, Hilal Günsel, Parham Taslımı

et al.

Inorganica Chimica Acta, Journal Year: 2024, Volume and Issue: 570, P. 122190 - 122190

Published: June 6, 2024

Language: Английский

Citations

5
Recent progress in visible light‐driven halogenation: Chlorination, bromination, and iodination DOI

Anh Thu Nguyen,

Houng Kang, Truong Giang Luu

et al.

Bulletin of the Korean Chemical Society, Journal Year: 2024, Volume and Issue: 45(9), P. 738 - 758

Published: Sept. 1, 2024

Abstract Halogenation is one of the most important transformations in organic synthesis. Halogenated compounds are employed many reactions to prepare useful molecules. Many methods have been developed introduce halogens into different compounds. Visible light‐mediated efficient, low‐toxic, and mild‐condition applied for various chemistry transformations. Remarkably, there has an increasing development application visible light‐induced halogenation recent years. Herein, we present a comprehensive summary including chlorination, bromination, iodination under light irradiation since 2020.

Language: Английский

Citations

5
Effects of p-coumaric acid on probiotic properties of Lactobacillus acidophilus LA-5 and lacticaseibacillus rhamnosus GG DOI

Buse Nur Derebasi,

Sena Davran Bulut,

Büşra Aksoy Erden

et al.

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(5)

Published: April 20, 2024

Language: Английский

Citations

2
Synthesis, characterization, crystal structure, biological activities, and molecular docking study of the (NHC)Pd(II)(Morp) (NHC: N-heterocyclic carbene, Morp: Morpholine) complexes DOI
Aydın Aktaş, Parham Taslımı, Selma Bal

et al.

Polyhedron, Journal Year: 2024, Volume and Issue: 257, P. 117016 - 117016

Published: April 30, 2024

Language: Английский

Citations

1
Investigation of cholinesterase and α-glucosidase enzyme activities, and molecular docking and dft studies for 1,2-disubstituted cyclopentane derivatives with phenyl and benzyl units DOI Creative Commons

Tekin Artunç,

Yasin Çetinkaya, Parham Taslımı

et al.

Molecular Diversity, Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

Abstract Six known products ( 4 – 9 ) were prepared from reaction of adipoyl chloride with 1,2,3-trimethoxybenzene according to the literature. From (2,3,4-trimethoxyphenyl)(2-(2,3,4-trimethoxyphenyl)cyclopent-1-en-1-yl)methanone them, four new 1,2-disubstituted cyclopentane derivatives 10–13 phenyl and benzyl units synthesized by reactions such as hydrazonation, catalytic hydrogenation bromination. The obtained compounds 4–13 examined for their in vitro inhibitory activity against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) α-glucosidase enzymes. All showed inhibition at nanomolar level K i values range 45.53 ± 7.35–631.96 18.88 nM AChE, 84.30 9.92–622.10 35.14 BChE, 25.47 4.46–48.87 7.33 α-Glu. In silico molecular docking studies potent performed active sites AChE (PDB: 1E66), BChE 1P0I), 5ZCC) compare effect bromine atom on mechanism. optimized structures, HOMO–LUMO energies electrostatic potential maps calculated using density functional theory B3LYP/6–31 + G(d,p).

Language: Английский

Citations

1
Effects of p-coumaric acid on Probiotic Properties of Lactobacillus acidophilus LA-5 and Lacticaseibacillus rhamnosus GG DOI Open Access

Buse Nur Derebasi,

Sena Davran Bulut,

Büşra Aksoy Erden

et al.

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 9, 2023

p-coumaric acid (p-CA) is one of the most abundant phenolic compounds in nature and human diet. Probiotic bacteria are microorganisms conferring health benefits on host when administered adequate amounts. The synbiotic interaction these two contents, found gastrointestinal tract, effect this intestines not known. Thus, study aimed to investigate relationship between p-CA Lactobacillus acidophilus LA-5 (LA-5), Lacticaseibacillus rhamnosus GG (LGG). They were grown presence different concentrations effects probiotic properties, as well vitro AChE BChE activities examined. Results indicated did negatively affect bacterial growth, but increased auto-aggregation both probiotics. While co-aggregation LGG against Escherichia coli, it decreased Staphylococcus aureus. Probiotics with more resistant pepsin. resistance bile salt, LGG. combinations efficiently suppressed inhibition (%) 11.31-68.06 13.47-65.14, respectively. Furthermore, surface analysis was conducted using FTIR LGG, changes cell components analyzed. results, recorded range 4000-600 cm⁻¹ resolution 4 cm⁻¹, demonstrated that significantly affected only phosphate/CH ratio for bacteria. These results indicate addition growth may enhance properties

Language: Английский

Citations

0