Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 275 - 275
Published: Jan. 13, 2025
Type
2
diabetes
mellitus
(T2DM),
a
serious
metabolic
disorder,
is
worldwide
health
problem
due
to
the
alarming
rise
in
prevalence
and
elevated
morbidity
mortality.
Chronic
hyperglycemia,
insulin
resistance,
ineffective
effect
secretion
are
hallmarks
of
T2DM,
leading
many
secondary
complications.
These
include,
particular,
cardiovascular
disorders,
diabetic
neuropathy,
nephropathy
retinopathy,
foot,
osteoporosis,
liver
damage,
susceptibility
infections
some
cancers.
Polyphenols
such
as
flavonoids,
phenolic
acids,
stilbenes,
tannins,
lignans
constitute
an
extensive
heterogeneous
group
phytochemicals
fresh
fruits,
vegetables
their
products.
Various
vitro
studies,
animal
model
studies
available
clinical
trials
revealed
that
flavonoids
(e.g.,
quercetin,
kaempferol,
rutin,
epicatechin,
genistein,
daidzein,
anthocyanins),
acids
chlorogenic,
caffeic,
ellagic,
gallic
curcumin),
stilbenes
resveratrol),
tannins
procyanidin
B2,
seaweed
phlorotannins),
pinoresinol)
have
ability
lower
enhance
sensitivity
improve
secretion,
scavenge
reactive
oxygen
species,
reduce
chronic
inflammation,
modulate
gut
microbiota,
alleviate
complications
T2DM.
The
interaction
between
polyphenols
conventional
antidiabetic
drugs
offers
promising
strategy
management
treatment
especially
advanced
disease
stages.
Synergistic
effects
with
been
documented,
but
also
antagonistic
interactions
may
impair
drug
efficacy.
Therefore,
additional
research
required
clarify
mutual
order
use
knowledge
applications.
Nevertheless,
dietary
can
be
successfully
applied
part
supportive
for
they
both
obvious
symptoms
Language: Английский
Characterization and Potential Food Applications of Oat Flour and Husks from Differently Colored Genotypes as Novel Nutritional Sources of Bioactive Compounds
Foods,
Journal Year:
2024,
Volume and Issue:
13(23), P. 3853 - 3853
Published: Nov. 28, 2024
Oats
are
gluten-free
cereals
rich
in
dietary
fiber,
β-glucans,
phenolic
acids,
flavonoids,
carotenoids,
vitamin
E,
and
phytosterols.
They
have
been
used
traditional
medicine
for
centuries
to
treat
hyperacidity,
acute
pancreatitis,
burns,
skin
inflammation.
This
study
assessed
the
nutritional
profile
of
oat
flour
(OF)
ground
husks
(OHs)
from
white,
brown,
black
hulled
genotypes,
as
well
antioxidant
antimicrobial
activity
their
extracts.
The
extracts
were
tested
on
six
strains
gastrointestinal
tract
pathogens.
OF
samples
had,
average,
a
high
protein
content
(15.83%),
fat
(6.27%),
β-glucan
(4.69%),
while
OH
fiber.
OHs
had
significantly
higher
average
total
compounds
compared
twice
capacity.
Ferulic
acid
was
predominant
all
samples,
followed
by
p-coumaric,
isoferulic,
vanillic,
syringic
acid.
traditionally
prepared
manifested
best
bactericidal
against
Listeria
monocytogenes,
Escherichia
coli,
Staphylococcus
haemolyticus,
Salmonella
typhimurium
least
sensitive
effect
investigated
samples.
Both
powdered
potential
applications
functional
food
industry
pharmacy
due
bioactive
compounds,
biological
activity,
overall
profile.
Language: Английский