The Potential of Colloidal Systems Based on Carbamate-Containing Hexadecylpiperidinium Surfactants in Biomedical Applications DOI Creative Commons
R. A. Kushnazarova, A. B. Mirgorodskaya,

D. D. Bekrenev

et al.

Colloids and Interfaces, Journal Year: 2024, Volume and Issue: 8(5), P. 57 - 57

Published: Oct. 17, 2024

New hexadecylpiperidinium surfactants, containing one or two butylcarbamate fragments, were synthesized. The antimicrobial activity, toxicity, aggregation behavior in aqueous solutions, and solubilization capacity of these surfactants towards the hydrophobic drug ibuprofen characterized. These demonstrated a high activity against wide range pathogenic bacteria, including both Gram-positive Gram-negative strains, as well fungi. By forming mixed-micellar compositions cationic surfactant 1-CB(Bu)-P-16 nonionic Brij®35, highly functional low-toxic formulations obtained. Furthermore, transition from mixed micelles to niosomes was accomplished, enhancing their potential delivery systems. Niosomes found be less toxic compared micelles, while also increasing solubility water. modification with made it possible increase stability system improve drug. data obtained indicate that new carbamate-containing have significant biomedical applications, particularly formulation advanced

Language: Английский

In Vitro Potentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes DOI Creative Commons

Islam Alfreahat,

Hamdi Nsairat, Ibrahim Al‐Deeb

et al.

Technology in Cancer Research & Treatment, Journal Year: 2025, Volume and Issue: 24

Published: Jan. 1, 2025

Doxorubicin (DOX) is a potent chemotherapeutic agent for breast cancer, but its effectiveness often diminished by resistance mechanisms, particularly through p-glycoprotein (P-gp) mediated drug efflux. Clarithromycin (CAM), macrolide antibiotic, inhibits multiple metabolic pathways including CYP3A and P-gp, potentially countering DOX resistance. This study aimed to evaluate the potentiation of against MCF-7 cancer cell line encapsulating both CAM in PEGylated liposomes. liposomes containing were prepared using thin film hydration method. The physicochemical properties liposomes, average particle size, polydispersity index (PDI), zeta potential, characterized. Encapsulation efficiencies assessed, stability was evaluated over 9 days at room temperature. Cell viability measured an IC50 assay, P-gp expression levels determined ELISA. CAM/DOX-PEGylated exhibited optimal size (238 ± 26.7 nm), PDI (0.29 0.107), potential (-20.9 2.17 mV). These maintained good regarding charge days. 81.05% 78.13% DOX. value 0.13 µM, representing significant reduction compared physical mixture (0.25 µM) free (0.21 cells. ELISA analysis showed approximately 5% with 1.61% results indicate that encapsulated enhances cells, likely inhibition p-glycoprotein. approach may offer promising strategy overcome improve chemotherapy outcomes.

Language: Английский

Citations

2
Chitosan and hyaluronic acid in breast cancer treatment: Anticancer efficacy and nanoparticle and hydrogel development DOI
Yanlin Jiang, Yu Cao, Yiqun Yao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140144 - 140144

Published: Jan. 21, 2025

Language: Английский

Citations

1
Advancements of metallic nanoparticles: A promising frontier in cancer treatment DOI Creative Commons
Ali Al‐Samydai, Maha N. Abu Hajleh,

Farah Al-Sahlawi

et al.

Science Progress, Journal Year: 2024, Volume and Issue: 107(4)

Published: Oct. 1, 2024

The incidence of cancer is increasing and evolving as a major source mortality. Nanotechnology has garnered considerable scientific interest in recent decades can offer promising solution to the challenges encountered with traditional chemotherapy. Nanoparticle utilization holds promise combating other diseases, offering exciting prospects for drug delivery systems medicinal applications. Metallic nanoparticles exhibit remarkable physical chemical properties, such their minute size, composition, structure, extensive surface area, rendering them versatile cost-effective. Research demonstrated significant beneficial impact on treatment, characterized by enhanced targeting abilities, gene activity suppression, improved efficiency. By incorporating ligands, functionalized metal ensure precise energy deposition within tumors, thereby augmenting treatment accuracy. Moreover, beyond therapeutic efficacy, serve valuable tools cell visualization, contributing diagnostic techniques. Utilizing allows simultaneous diagnosis while also facilitating controlled release, thus revolutionizing care. This narrative review investigates advancements types mechanisms cells, application clinical scenarios, potential toxicity medicine.

Language: Английский

Citations

8
Niosomes as a Targeted Drug Delivery system in the Treatment of Breast Cancer: Preparation, Classification, and Mechanisms of Cellular Uptake DOI

Muneeb UrRahman,

Hafiz Rashid Hussain,

Huzaifa Akram

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 36

Published: Feb. 18, 2025

Breast cancer remains one of the significant health issues across globe, being diagnosed in millions women worldwide annually. Conventional therapeutic options have substantial adverse effects due to their non-specificity and limited drug bioavailability. Niosomes, novel delivery systems formed from non-ionic surfactants, with or without cholesterol charge-inducing agents, are used as treating BC. Their formulation by various methods enhances efficacy bioavailability minimizes side effects. Niosomal tamoxifen exhibits target enhanced stability, whereas docetaxel methotrexate show sustained controlled release, respectively.5-Fluorouracil, doxorubicin, paclitaxel, cyclophosphamide, epirubicin improved cytotoxic against BC when combined other agents. Furthermore, repurposed niosomal formulations anti-cancer drugs penetration, reduced tumor volume, significantly anti-tumor effect. This review article focuses on composition niosomes application treatment then examines how could contribute research.

Language: Английский

Citations

0
Innovative approaches in breast cancer therapy: repurposing nanocarriers for enhanced outcomes DOI

Sana Naaz Siddiqui,

Md. Faheem Haider, M.A. Rahman

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
PREPARATION AND ASSESSMENT OF NAIL LACQUER INCORPORATING CICLOPIROX OLAMINE-LOADED NIOSOMES DOI Open Access
Ayushi Chauhan, Mansi Butola, Vikash Jakhmola

et al.

Asian Journal of Pharmaceutical and Clinical Research, Journal Year: 2025, Volume and Issue: unknown, P. 169 - 174

Published: April 7, 2025

Objective: The emergence of transungual drug delivery systems represents a significant advancement in treating nail-related conditions, particularly fungal infections like onychomycosis. current study aims to formulate ciclopirox olamine (CPO)-loaded niosomal nail lacquer for the treatment Methods: CPO niosomes were synthesized using thin-film hydration method, incorporating different proportions cholesterol, Span 60, and Tween 40. Niosomes assessed their content, encapsulation efficiency, particle size, zeta potential. Results: Among various formulations niosomes, formulation F5 showed adequate loading 94.51%, polydispersity index 0.171, potential −5.10 mV. Following that, optimized (F5) suspension was used develop formulation. maximum vitro release, achieving rate 92.22%. ex vivo conducted Franz diffusion cell apparatus, resulting release approximately 90.67%. zone inhibition obtained found more than pure solution. Conclusion: oral administration antifungal agents, such as allylamines azoles, is associated with numerous adverse effects from requirement high dosages. These issues can be addressed by formulating medications lacquer, significantly lower dosages treatment, which consequently leads reduced side

Language: Английский

Citations

0
Niosomes: A Revolution in Sustainable and Targeted Drug Delivery-Green Synthesis, Precision Medicine, and Beyond DOI

Harsh Pirojiya,

Kiran Dudhat

Regenerative Engineering and Translational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Language: Английский

Citations

2
Pimozide-loaded nanostructured lipid carriers: Repurposing strategy against lung cancer DOI Creative Commons

Wafa’ A. AL-Haj,

Hamdi Nsairat, Mohamed El‐Tanani

et al.

Science Progress, Journal Year: 2024, Volume and Issue: 107(4)

Published: Oct. 1, 2024

Objective This study aimed to repurpose pimozide (PMZ) by incorporating it into nanostructured lipid carriers (NLC) using a modified melting emulsion ultrasonication method. Methods We employed stearic and oleic acids in 1:1 ratio as lipids, with Tween 80 PEG 4000 surfactants. The formulation was analyzed for particle size, zeta potential, encapsulation efficiency. Transmission electron microscopy (TEM) used confirm the spherical shape of particles. release profile PMZ-NLC evaluated under different pH conditions, anticancer activity tested on A549 cell lines. Results exhibited an average size 136 ± 2.9 nm, potential −25.1 0.9 mV, efficiency 86% 11. TEM confirmed NLCs. PMZ from pH-sensitive, enhancing tumor targeting. IC 50 values were 16.5 μM free 12.9 after 72 h. Discussion demonstrated improved compared PMZ, suggesting that enhances drug's effectiveness. pH-sensitive supports its targeted therapy lung cancer. Conclusions showed safe effective strategy cancer treatment. Further investigation is warranted evaluate vivo efficacy, long-term safety, clinical application.

Language: Английский

Citations

1
Green synthesized Zingiber officinale -ZnO nanoparticles: anticancer efficacy against 3D breast cancer model DOI Creative Commons

Ruqaya Alhaddad,

Bassam M. Abualsoud, Ibrahim Al‐Deeb

et al.

Future Science OA, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 14, 2024

Methodology: Physical characterization and biological activity were performed against 2D, 3D spheroids MCF-7 cell lines.

Language: Английский

Citations

1
The Potential of Colloidal Systems Based on Carbamate-Containing Hexadecylpiperidinium Surfactants in Biomedical Applications DOI Creative Commons
R. A. Kushnazarova, A. B. Mirgorodskaya,

D. D. Bekrenev

et al.

Colloids and Interfaces, Journal Year: 2024, Volume and Issue: 8(5), P. 57 - 57

Published: Oct. 17, 2024

New hexadecylpiperidinium surfactants, containing one or two butylcarbamate fragments, were synthesized. The antimicrobial activity, toxicity, aggregation behavior in aqueous solutions, and solubilization capacity of these surfactants towards the hydrophobic drug ibuprofen characterized. These demonstrated a high activity against wide range pathogenic bacteria, including both Gram-positive Gram-negative strains, as well fungi. By forming mixed-micellar compositions cationic surfactant 1-CB(Bu)-P-16 nonionic Brij®35, highly functional low-toxic formulations obtained. Furthermore, transition from mixed micelles to niosomes was accomplished, enhancing their potential delivery systems. Niosomes found be less toxic compared micelles, while also increasing solubility water. modification with made it possible increase stability system improve drug. data obtained indicate that new carbamate-containing have significant biomedical applications, particularly formulation advanced

Language: Английский

Citations

0