Caffeine and sclareol reduce the sedative effects of linalool, possibly through the GABA A interaction pathway: molecular insights through in vivo and in silico studies DOI
Muhammad Torequl Islam, Md. Sakib Al Hasan, Jannatul Ferdous

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Abstract Study background: Linalool (LIN) has some important neuropharmacological activities, including anxiolytic and sedative effects. It is also clear that it protects experimental animals from convulsions Alzheimer's disease. On the other hand, caffeine (CAF) sclareol (SCL) have neurostimulatory potential. Aim To evaluate effect possible molecular mechanisms of CAF with LIN and/or SCL through in vivo silico studies. Methodology: (10 mg/kg) alone or (50 were intraperitoneally (i.p.) treated before thirty minutes pentobarbital sodium (TS) injection (40 mg/kg, i.p.) to mice observed for latency duration sleep up 4 hours. understand action these drugs, we performed docking studies GABAA receptor respective submits. Results Findings suggest exerted significant (p < 0.05) effects on animals. in their combinations significantly reduced LIN’s mice. CAF, LIN, showed binding affinities ‒5.7, ‒4.7, ‒7.4 kcal/mol 6X3X (α1 β2 subunits), respectively. Conclusion effects, while this We suppose drugs may exert intrecation pathway. Further are required confirm results.

Language: Английский

An insight into the anticancer potentials of lignan arctiin: A comprehensive review of molecular mechanisms DOI Creative Commons
Raihan Chowdhury, Md. Shimul Bhuia, Polrat Wilairatana

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32899 - e32899

Published: June 1, 2024

Natural products are being developed as possible treatment options due to the rising prevalence of cancer and harmful side effects synthetic medications. Arctiin is a naturally occurring lignan found in numerous plants exhibits different pharmacological activities, along with cancer. To elucidate anticancer properties underlying mechanisms action, comprehensive search various electronic databases was conducted using appropriate keywords identify relevant publications. The findings suggest that arctiin against tumor formation cancers such cervical, myeloma, prostate, endothelial, gastric, colon several preclinical investigations. This compound exerts its effect through cellular mechanisms, including mitochondrial dysfunction, cell cycle at phases (G2/M), inhibition proliferation, apoptotic death, cytotoxic effects, well migration invasion malignant cells. Moreover, study also revealed that, among pathways, shown be more potent terms PI3K/AKT JAK/STAT signaling pathways. However, pharmacokinetic investigation indicated compound's poor oral bioavailability. Because these findings, might considered promising chemotherapeutic drug candidate.

Language: Английский

Citations

16
An Insight of Plant Source, Toxicological Profile, and Pharmacological Activities of Iridoid Loganic Acid: A Comprehensive Review DOI Open Access
Asma Aktar, Md. Shimul Bhuia, Raihan Chowdhury

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Abstract This study evaluates the pharmacological effects of iridoid glucoside loganic acid, a plant constituent with diverse properties, based on literature, and explores underlying cellular mechanisms for treating several ailments. Data were collected from reliable electronic databases, including PubMed, Scopus, Web Science, Google Scholar, etc. The results demonstrated anti‐inflammatory, anti‐oxidant, other protective acid metabolic diseases disorders such as atherosclerosis, diabetes, obesity, in addition to its osteoprotective anticancer properties. antioxidant activity demonstrates capacity protect cells oxidative damage mitigates inflammation by reducing inflammatory cytokines involving TNF‐α IL‐6, substantially upregulating expression PPAR‐γ/α, decreasing clinical signs inflammation‐related conditions related hypertriglyceridemia atherosclerosis. Meanwhile, inhibits bone loss, exhibits properties increasing mRNA levels synthesizing genes Alpl, Bglap, Sp7, significantly increases osteoblastic proliferation preosteoblast cells. Loganic is an anti‐metastatic drug that reduces MnSOD expression, EMT metastasis, prevents migration, proliferation, invasion hepatocellular carcinoma However, additional trials are required assess safety, efficacy, human dose.

Language: Английский

Citations

12
A mechanistic insight into the anticancer potentials of resveratrol: Current perspectives DOI
Md. Shimul Bhuia, Raihan Chowdhury,

Mst. Asma Akter

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 3877 - 3898

Published: May 20, 2024

Abstract Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, berry fruits. It renowned for its several health advantages. The well known anticancer properties, substantial amount of clinical evidence has also established promise chemotherapeutic agent. This study focuses on assessing the properties resveratrol gaining insight into underlying molecular mechanisms. evaluates biopharmaceutical, toxicological characteristics, utilization to determine suitability further development reliable Therefore, information about preclinical studies was collected from different electronic databases up‐to‐date (2018–2023). Findings this revealed that potent therapeutic benefits against cancers involving mechanisms, induction oxidative stress, cytotoxicity, inhibition cell migration invasion, autophagy, arresting S phase cycle, apoptotic, anti‐angiogenic, antiproliferative effects by regulating pathways including PI3K/AKT, p38/MAPK/ERK, NGFR‐AMPK‐mTOR, so on. However, compound poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation resveratrol). Clinical application showed types cancer with no serious adverse effects. We suggest additional extensive check efficacy, safety, long‐term hazards. could involve larger number samples establish drug treatment cancer.

Language: Английский

Citations

10
Botanical sources, biopharmaceutical profile, anticancer effects with mechanistic insight, toxicological and clinical evidence of prunetin: a literature review DOI

Sumaya Akter Bithi,

Md. Sakib Al Hasan, Md. Shimul Bhuia

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 3, 2025

Language: Английский

Citations

1
Caffeine and sclareol take the edge off the sedative effects of linalool, possibly through the GABAA interaction pathway: molecular insights through in vivo and in silico studies DOI
Muhammad Torequl Islam, Md. Sakib Al Hasan, Jannatul Ferdous

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Citations

1
GabaAergic sedative prospection of sclareol-linalool co-treatment: An antagonistic intervention through in vivo and in silico studies DOI
Muhammad Torequl Islam, Md. Sakib Al Hasan, Jannatul Ferdous

et al.

Neuroscience Letters, Journal Year: 2024, Volume and Issue: unknown, P. 138060 - 138060

Published: Nov. 1, 2024

Language: Английский

Citations

8
Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono‐ or Combination Therapies in the Management of Cancer: An Update with Molecular Mechanisms DOI Creative Commons

Tanzila Akter Eity,

Md. Shimul Bhuia, Raihan Chowdhury

et al.

Journal of Tropical Medicine, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Quercetin, a major representative of the flavonol subclass found abundantly in almost all edible vegetables and fruits, showed remarkable therapeutic properties was beneficial numerous degenerative diseases by preventing lipid peroxidation. Quercetin is different diseases, such as atherosclerosis chronic inflammation. This study aims to find out anticancer activities quercetin determine mechanisms pathways which are responsible for effect. It also revealed biopharmaceutical, toxicological characteristics, clinical utilization evaluate its suitability further investigations reliable drug. All relevant data concerning this compound with cancer collected using scientific search engines, including PubMed, Springer Link, Wiley Online, Web Science, SciFinder, ScienceDirect, Google Scholar. review demonstrated that strong properties, apoptosis, inhibition cell proliferation, autophagy, cycle arrest, angiogenesis, invasion migration against various types cancer. Findings could significantly moderate regulate pathways, PI3K/AKT‐mTORC1 pathway, JAK/STAT signaling system, MAPK MMP NF‐ κ B p‐Camk2/p‐DRP1 pathway. However, poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation quercetin). Moreover, expressed no toxic effect investigated subjects. Based on view these findings, it might be considered chemotherapeutic drug candidate treatment cancers. more studies suggested establish proper efficacy, safety, human dose.

Language: Английский

Citations

5
Therapeutic Promises of Ferulic Acid and its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms DOI
Md. Shimul Bhuia, Raihan Chowdhury, Manik Chandra Shill

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(7)

Published: May 17, 2024

Ferulic acid (FA) is a naturally occurring phenolic compound commonly found in the plant Ferula communis. This study aims to investigate hepatoprotective effect of FA and its derivatives (methyl ferulic trans-ferulic acid) against oxidative stress inflammation-related hepatotoxicity due toxicants based on results different non-clinical preclinical tests. For this, data was collected from reliable electronic databases such as PubMed, Google Scholar, ScienceDirect, etc. The this investigation demonstrated that have potent effects damage. findings also revealed these protective are antioxidant anti-inflammatory chemical compound. analogues significantly inhibit free radical generation hinder proinflammatory markers inflammatory enzymes, resulting diminished cytotoxic apoptotic hepatocyte death. compounds prevent intracellular lipid accumulation provide effects.

Language: Английский

Citations

4
Therapeutic Efficacy Studies on the Monoterpenoid Hinokitiol in the Treatment of Different Types of Cancer DOI Creative Commons
Md. Shimul Bhuia, Raihan Chowdhury, Meher Afroz

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

ABSTRACT Hinokitiol (HK), a monoterpenoid that naturally occurs in plants belonging to the Cupressaceae family, possesses important biological activities, including an anticancer effect. This review summarizes its potential and draws possible molecular interventions. In addition, it evaluates biopharmaceutical, toxicological properties, clinical application of HK establish viability for future advancement as dependable medication. The assessment is based on most recent information available from various databases. Findings demonstrate substantial therapeutic advantages against diverse types cancer (colon, cervical, breast, bone, endometrial, liver, prostate, oral, skin) through mechanisms. induces oxidative stress, cytotoxicity, apoptosis, cell‐cycle arrest at G S phases, autophagy modulation phosphatidylinositol 3‐kinase (PI3K)/Akt/mammalian target rapamycin (mTOR), p38/ERK/MAPK, nuclear factor kappa B, c‐Jun N‐terminal kinase signaling pathways. Furthermore, this compound exhibits good oral bioavailability with excellent plasma clearance. Clinical uses without any significant negative effects. A thorough study pertinent data suggests may serve viable candidate developing novel therapies. Consequently, more extensive studies are necessary evaluate treatment efficacy, safety, long‐term hazards.

Language: Английский

Citations

0
Therapeutic Promises of Bioactive Rosavin: A Comprehensive Review with Mechanistic Insight DOI
Asma Aktar, Md. Shimul Bhuia, Raihan Chowdhury

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(7)

Published: May 16, 2024

Rosavin is an alkylbenzene diglycoside primarily found in Rhodiola rosea (L.), demonstrating various pharmacological properties a number of preclinical test systems. This study focuses on evaluating the effects rosavin and underlying molecular mechanisms based different non-clinical investigations. The findings revealed that has anti-microbial, antioxidant, protective effects, including neuroprotective against neurodegenerative ailments such as mild cognitive disorders, neuropathic pain, depression, stress, well gastroprotective, osteoprotective, pulmoprotective, hepatoprotective activities. effect due to its capability diminish inflammation oxidative stress. compound also manifested anticancer cancer via exerting cytotoxicity, apoptotic cell death, arresting phases (G

Language: Английский

Citations

3