Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 24, 2025
Polyphenols,
naturally
occurring
phytonutrients
found
in
plant-based
foods,
have
attracted
significant
attention
for
their
potential
therapeutic
effects
neurological
diseases
and
neuroinflammation.
These
compounds
possess
diverse
neuroprotective
capabilities,
including
antioxidant,
anti-inflammatory,
anti-amyloid
properties,
which
contribute
to
mitigating
the
progression
of
neurodegenerative
conditions
such
as
Alzheimer's
Disease
(AD),
Parkinson's
(PD),
Dementia,
Multiple
Sclerosis
(MS),
Stroke,
Huntington's
(HD).
Polyphenols
been
extensively
studied
ability
regulate
inflammatory
responses
by
modulating
activity
pro-inflammatory
genes
influencing
signal
transduction
pathways,
thereby
reducing
neuroinflammation
neuronal
death.
Additionally,
polyphenols
shown
promise
various
cellular
signaling
pathways
associated
with
viability,
synaptic
plasticity,
cognitive
function.
Epidemiological
clinical
studies
highlight
polyphenol-rich
diets
decrease
risk
alleviate
symptoms
disorders
Furthermore,
demonstrated
through
regulation
key
Akt,
Nrf2,
STAT,
MAPK,
play
critical
roles
neuroprotection
body's
immune
response.
This
review
emphasizes
growing
body
evidence
supporting
combating
neurodegeneration
neuroinflammation,
well
enhancing
brain
health.
Despite
substantial
promising
hypotheses,
further
research
investigations
are
necessary
fully
understand
role
establish
them
advanced
targets
age-related
neuroinflammatory
conditions.
Language: Английский
Chemical Composition and Health Benefits of Grape and Grape Products
Published: April 28, 2025
Review
Chemical
Composition
and
Health
Benefits
of
Grape
Products
Didem
Şöhretoğlu
1,*,
Ayşenur
Duru
1,
Öznur
Bengisu
Köylüoğlu
2
1
Department
Pharmacognosy,
Faculty
Pharmacy,
Hacettepe
University,
Sıhhiye,
Ankara
06100,
Turkey
*
Correspondence:
[email protected]
Received:
February
2025;
Revised:
19
March
Accepted:
6
April
Published:
28
2025
Abstract:
is
a
highly
nutritious
fruit
that
widely
consumed
around
the
world.
It
cultivated
We
provided
knowledge
on
phytochemical
contents,
biological
impacts,
economic
worth
grapes.
Polyphenols
are
main
constituents
grape
derivated
products.
They
exhibited
antioxidant,
anti-inflammatory,
antihepatotoxic
properties.
The
most
prominent
effect
was
cardioprotective
effect.
shown
by
in
vitro,
vivo
studies
as
well
human
studies.
Language: Английский