Fitoterapia, Journal Year: 2024, Volume and Issue: 180, P. 106350 - 106350
Published: Dec. 17, 2024
Language: Английский
Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Abstract Endophytic fungi represent a significant renewable resource for the discovery of pharmaceutically important compounds, offering substantial potential new drug development. Their ability to address growing issue resistance has drawn attention from researchers seeking novel, nature-derived lead molecules that can be produced on large scale meet global demand. Recent advancements in genomics, metabolomics, bioinformatics, and improved cultivation techniques have significantly aided identification characterization fungal endophytes their metabolites. Current estimates suggest there are approximately 1.20 million globally, yet only around 16% (190,000) been identified studied detail. This underscores vast untapped pharmaceutical research. Research increasingly focused transformation bioactive compounds by through chemical enzymatic processes. A notable example is anthraquinone derivative 6-O-methylalaternin, whose cytotoxic enhanced addition hydroxyl group, sharing structural similarities with its parent compound macrosporin. These structure-bioactivity studies open up avenues developing safer more effective therapeutic agents synthesizing targeted derivatives. Despite immense promise, challenges remain, particularly large-scale understanding complexities biosynthetic pathways. Additionally, genetic manipulation optimized metabolite production still infancy. Future research should aim overcome these limitations focusing efficient methods deeper exploration endophytes’ metabolic capabilities fully harness potential. Graphical
Language: Английский
Citations
1
Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 158, P. 108342 - 108342
Published: March 6, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8385 - 8385
Published: Aug. 1, 2024
Auxin, a plant hormone, plays diverse roles in the modulation of growth and development. The transport signal transduction auxin are regulated by various factors involved shaping morphology responding to external environmental conditions. is primarily governed following two gene families: response factor (
Language: Английский
Citations
1
Frontiers in Tropical Diseases, Journal Year: 2024, Volume and Issue: 5
Published: Aug. 8, 2024
Vaccine development tools for fungal infections are undergoing transformation where newer technologies like nanotechnology and bioinformatics used to create new improved vaccine candidates. Immunocompromised individuals those with multiple chronic conditions especially vulnerable invasive infections. These patients at increased risk of developing widespread experiencing poor health outcomes. Current management is associated diagnostic challenges, side effects, resistance. Vaccination an effective strategy prevent boost immunity. Despite the significant burden disease, there currently no licensed vaccines available. This review focused on various strategies, including whole-cell, subunit, nucleic acid-based vaccines. Various challenges safety concerns, weak nonspecific immune response, ideal adjuvants, need drug delivery systems also highlighted in this review. Sustained antigenic addressing host response variability, eliciting persistent predictable crucial development. Standardized protocols robust preclinical studies essential clinical potential Exploring novel targets using advanced bioinformatics, nanotechnology, reverse vaccinology being rapidly explored.
Language: Английский
Citations
0
Fitoterapia, Journal Year: 2024, Volume and Issue: 180, P. 106350 - 106350
Published: Dec. 17, 2024
Language: Английский
Citations
0