New Prospective Insecticidal Agents Based on N‐(arylcarbamothioyl)arylmide Derivatives Against Spodoptera frugiperda: Design, Synthesis, Toxicological, Biological, Biomedical Studies and Antibacterial Activity

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(11)

Published: July 22, 2024

Abstract In this work, a novel series of N ‐(arylcarbamothioyl)arylmide) 2–11 were synthesized by treating One‐Pot three‐multicomponent Aroyl chloride, ammonium isothiocyanate and amine compounds under refluxing conditions. Using spectroscopic methods, the chemical structure novelty developed investigated. After five days, proposed derivatives’ insecticidal bioassay was assessed using median lethal concentration (LC 50 ) against second & fourth larvae Spodoptera frugiperda as toxicity agents. The findings showed that, to varying degrees, every tested substance exerted effects on S. in both their instars. Compound 9 most poisonous them all, having an LC instars 60.45 123.21 mg/L, respectively. Additionally, few biological biochemical characteristics substances that generated lab setting also looked at. Furthermore, work discusses how discover may one day be employed Finally, all designed components monitored for antibacterial effectiveness toward Gram‐positive Gram‐negative bacteria.

Language: Английский

Green synthesis, characterization, and bio-efficacy of novel benzamides as insect growth regulator (IGR) analogues against Spodoptera frugiperda

Toxicological & Environmental Chemistry Reviews, Journal Year: 2025, Volume and Issue: 107(3), P. 409 - 427

Published: Feb. 23, 2025

According to the majority of problems caused by use insecticides, rapid enhancement resistance conventional chemical insecticide compounds is another significant impetus for creation new effective insecticidal agents. One keys meeting this challenge explore classes with diverse modes action. The safe and distinctively designed organic ingredients essential development in order reduce effects derivatives. So, we prepared that have structure analogues insect growth regulator pyriproxyfen then tested them against Spodoptera frugiperda. structures produced products were proven using elemental analysis spectroscopic results. When synthetic derivatives toxicity S. frugiperda, 4-(2-hydroxy-3-phenoxypropoxy)phenyl-1,4-bis(2E)-3-(4chlorophenyl)prop-2-en-1-one 3 showed high activity (LC50 = 26.8 mg/L) compared pyriproxyfen, while other components moderate low effectiveness. In addition to, some biological parameters, including adult longevity, pupal weight, fraction normal, deformed pupae, was also conducted. This work created a pathway identification novel class insecticides.

Language: Английский

Functionalized Carbohydrazide: Synthesis, Insecticide Evaluation, Biological and Histological Studies of some New Carbohydrazide Derivatives against Spodoptera frugiperda

Journal of the Indian Chemical Society, Journal Year: 2024, Volume and Issue: 101(12), P. 101464 - 101464

Published: Nov. 6, 2024

Language: Английский