Patient‐derived xenograft model in cancer: establishment and applications

MedComm, Journal Year: 2025, Volume and Issue: 6(2)

Published: Jan. 19, 2025

Abstract The patient‐derived xenograft (PDX) model is a crucial in vivo extensively employed cancer research that has been shown to maintain the genomic characteristics and pathological structure of patients across various subtypes, metastatic, diverse treatment histories. Various strategies utilized PDX models can offer valuable insights into mechanisms tumor progression, drug resistance, development novel therapies. This review provides comprehensive overview establishment applications models. We present an history current status models, elucidate construction methodologies for different tumors, conduct comparative analysis highlight distinct advantages limitations this relation other are elucidated domain comprehending underlying therapy, which highlights broad fields chemotherapy, targeted delivery systems, combination antibody–drug conjugates radiotherapy. Furthermore, with multiomics single‐cell analyses also emphasized. application clinical personalized medicine additionally

Language: Английский

Nutrition and Dietary Pattern Associated With Chronic Obstructive Pulmonary Disease

eFood, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 6, 2025

ABSTRACT Chronic Obstructive Pulmonary Disease (COPD) is one of the world's most significant causes illness and mortality. It vital to identify modifiable risk factors for COPD prevention therapy, scientific community has started focus closely on nutrition as a crucial component management, from treatment. For progression, management obstructive lung illnesses like asthma COPD, diet may be COPD. This review examined connection between dietary habits, nutrient consumption, disorders. Additionally, this highlights summarizes evidence observational clinical studies regarding influence nutrients habits function onset, outcomes disease. Regarding advancement or supplemental an impact treatment Better pulmonary function, less deterioration in lower linked nutraceuticals, particularly those with antioxidant anti‐inflammatory effects, when combined balancepatterns. Health providers use evidence‐based lifestyle approach help counsel patients toward improved health if they are aware implications

Language: Английский

Exploring anti-tumor potential of food and medicine homology substances: An in-silico evaluation of Citri Grandis Exocarpium against gallbladder cancer

Food & medicine homology., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский