Therapeutic Potential of Artemisia campestris Essential Oil: Antioxidant, Anti‐Inflammatory, and Anticancer Insights From In Silico Analysis
Biomedical Chromatography,
Journal Year:
2025,
Volume and Issue:
39(3)
Published: Feb. 7, 2025
Artemisia
campestris
subsp.
(tuguft)
is
a
medicinal
plant
traditionally
used
in
Algerian
medicine.
This
study
investigates
the
chemical
composition
and
bioactivity
of
its
essential
oil
(ACEO).
Gas
chromatography-mass
spectrometry
(GC-MS)
analysis
identified
key
compounds,
including
linalyl
acetate
(2.92%),
geranyl
(2.45%),
eucalyptol
(1.38%).
ACEO
demonstrated
significant
antioxidant
activity,
with
IC50
values
11.09
μg/mL
(DPPH),
15.81
(FRAP),
22.70
(β-carotene).
It
also
enhanced
peroxidase
activity
by
82.67
U/g.
The
anti-inflammatory
effects
were
confirmed
an
18.87
μg/mL.
Notably,
silico
molecular
docking
revealed
that
3-cyclopentyl-N-(2-(3,4-dimethoxyphenyl)ethyl)
exhibits
strong
binding
affinity
to
phosphoinositide
3-kinase
gamma,
target
for
pancreatic
cancer
therapy,
suggesting
potential
anticancer
activity.
These
findings
underscore
therapeutic
ACEO,
highlighting
antioxidant,
anti-inflammatory,
properties.
Language: Английский
GC/MS and LC Composition Analysis of Essential Oil and Extracts From Wild Rosemary: Evaluation of Their Antioxidant, Antimicrobial, and Anti‐Inflammatory Activities
Nasma Mahboub,
No information about this author
Inasse Cherfi,
No information about this author
Salah Eddine Laouini
No information about this author
et al.
Biomedical Chromatography,
Journal Year:
2025,
Volume and Issue:
39(5)
Published: April 10, 2025
ABSTRACT
Rosmarinus
officinalis
L.
(rosemary)
is
a
widely
used
medicinal
plant
known
for
its
antioxidant,
antimicrobial,
and
anti‐inflammatory
properties.
This
study
evaluates
the
bioactive
potential
of
essential
oil
(EO),
methanolic
(ME),
aqueous
(AE)
extracts.
GC‐MS
analysis
identified
α‐pinene
(21.37%),
bornanone
(12.73%),
eucalyptol
(8.28%)
as
major
EO
components,
while
HPLC
revealed
ME's
richness
in
salicylic
acid
(5.11
μg/mg)
rutin
(0.43
μg/mg).
Antioxidant
activity,
assessed
via
DPPH
FRAP
assays,
showed
ME
with
strongest
radical
scavenging
capacity
(IC
50
=
27.30
±
2.4%)
reducing
power
90.88
6.7%).
Antimicrobial
testing
most
effective,
particularly
against
Staphylococcus
aureus
(33
mm
inhibition
zone)
Bacillus
subtilis
(32
mm),
AE
exhibited
moderate
activity.
Pseudomonas
aeruginosa
was
resistant
to
all
Additionally,
demonstrated
notable
activity
55.88
1.02%).
These
findings
highlight
rosemary
rich
source
compounds
strong
pharmacological
potential,
positioning
best
potent
an
effective
agent.
Language: Английский
PEG‐Modified NiFe₂O₄ Nanocomposites: Synthesis, Characterization, and Multifunctional Biomedical Applications in Antioxidant, Anti‐Inflammatory, Photoprotective, Antiemolytic, and Antibacterial Therapies
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(6)
Published: May 19, 2025
ABSTRACT
This
study
reports
the
synthesis
and
characterization
of
polyethylene
glycol
(PEG)‐modified
NiFe₂O₄
nanocomposite
(NiFe₂O₄@PEG
NC)
using
a
co‐precipitation
method.
Characterization
techniques,
including
XRD,
confirmed
successful
formation
cubic
spinel
structure,
with
crystallite
sizes
18.35
nm
for
NC
20.13
NiFe₂O₄@PEG
NC.
Optical
analysis
revealed
reduction
in
both
direct
(from
3.78
to
2.72
eV)
indirect
1.36
1.05
band
gaps
due
PEG
modifying,
enhancing
light
absorption
reducing
Urbach
energy,
indicating
improved
material
quality.
The
antioxidant
activity
showed
significant
increase
total
capacity
(TAC)
from
2.78
17.4
μgAA/mg,
moderate
DPPH
radical
scavenging
increasing
4.44%
36.88%.
Biological
assessments
demonstrated
strong
anti‐inflammatory
78.56%
inhibition
at
1000
μg/mL,
photoprotective
properties
(SPF
increased
8.57
21.43),
enhanced
antihemolytic
(inhibition
100
μg/mL
18.05%).
NCs
also
exhibited
antibacterial
against
several
bacterial
strains.
modifying
significantly
stability,
biocompatibility,
functional
NCs,
making
them
promising
candidates
biomedical
applications.
Language: Английский
Therapeutic Efficacy of Salvia chudaei Ethanol Extract in Hyperlipidemia, Hyperglycemia, and Oxidative Stress in Triton X‐100‐Induced Wistar Rats
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 31, 2024
ABSTRACT
The
study
explored
the
efficacy
of
Salvia
chudaei
ethanolic
extract
in
managing
hyperlipidemia,
hyperglycemia,
and
oxidative
stress
induced
by
Triton
X‐100
Wistar
rats.
Twenty‐four
rats
were
divided
into
four
groups:
Control,
S.
‐treated,
Triton‐induced
hyperlipidemic,
a
combination
+
treatment.
raised
serum
levels
total
cholesterol,
triacylglycerol,
low‐density
lipoprotein
(LDL)
while
lowering
high‐density
(HDL)
leading
to
marked
increased
malondialdehyde
(MDA)
reduced
antioxidant
activity
liver
kidney
tissues.
Administration
effectively
reversed
these
adverse
effects,
significantly
LDL
levels,
improving
HDL
cholesterol.
It
also
enhanced
defenses
markers,
demonstrating
its
protective
role
against
metabolic
dysfunction.
High‐performance
liquid
chromatography
analysis
confirmed
presence
bioactive
compounds
that
contribute
benefits.
findings
suggest
possesses
strong
antihyperlipidemic,
antihyperglycemic,
properties,
making
it
promising
natural
agent
for
preventing
treating
hyperlipidemia
stress.
This
positions
as
potential
new
therapeutic
approach
management
disorders.
Language: Английский