The m6A-ncRNAs axis in diabetes complications: novel mechanism and therapeutic potential DOI Creative Commons
Siming Yu, Chunsheng Li, Xinxin Lu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: June 24, 2024

Diabetes, a multifaceted metabolic disorder, poses significant global health burden with its increasing prevalence and associated complications, such as diabetic nephropathy, retinopathy, cardiomyopathy, angiopathy. Recent studies have highlighted the intricate interplay between N 6 -methyladenosine (m A) non-coding RNAs (ncRNAs) in key pathways implicated these diabetes like cell apoptosis, oxidative stress, inflammation. Thus, understanding mechanistic insights into how m A dysregulation impacts expression function of ncRNAs opens new avenues for therapeutic interventions targeting A-ncRNAs axis complications. This review explores regulatory roles modifications ncRNAs, stresses role A-ncRNA providing potential diseases.

Language: Английский

Research progress of non-coding RNA regulating the role of PANoptosis in diabetes mellitus and its complications DOI
Guangyu Han, Kaibo Hu, Tao Luo

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Language: Английский

Citations

3
ncRNA-Mediated Pyroptosis in Cerebral Ischemia-Reperfusion Injury: Pathophysiology, Mechanisms, and Therapeutic Perspectives DOI Creative Commons

Ruiyi Xu,

Peng Quan, Wen Chen

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 141 - 141

Published: Feb. 22, 2025

Cerebral ischemia-reperfusion injury (CIRI) is a complex pathological process triggered by transient obstruction of blood flow and subsequent reperfusion, ultimately leading to intracellular disturbances such as oxidative stress, inflammatory responses, programmed cell death. Among the various types death, pyroptosis (an kind regulated death) has received increasing attention due its involvement in key neurovascular unit cells, including endothelial neurons, microglia, astrocytes. Intriguingly, accumulating evidence demonstrates that non-coding RNAs (ncRNAs), long RNAs, microRNAs, circular can modulate multiple stages CIRI. This review synthesizes recent findings on ncRNAs-regulated We highlight molecular underpinnings pyroptotic activation following ischemic discuss how ncRNAs shape these mechanisms. By elucidating interactions between pyroptosis-related pathways, we intend present innovative viewpoints for early diagnosis development potential therapeutic strategies mitigate

Language: Английский

Citations

0
Pyroptosis in Diabetic Peripheral Neuropathy and its Therapeutic Regulation DOI Creative Commons
Abdullah Al Mamun, Chuxiao Shao, Peiwu Geng

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 3839 - 3864

Published: June 1, 2024

Pyroptosis is a pro-inflammatory form of cell death resulting from the activation gasdermins (GSDMs) pore-forming proteins and release several factors. However, inflammasomes are intracellular protein complexes that cleave gasdermin D (GSDMD), leading to formation robust membrane pores initiation pyroptosis. Inflammasome gasdermin-mediated pore important intrinsic processes in classical pyroptotic signaling pathway. Overactivation NOD-like receptor thermal domain associated 3 (NLRP3) inflammasome triggers pyroptosis amplifies inflammation. Current evidence suggests overactivation may further induce progression cancers, nerve injury, inflammatory disorders metabolic dysfunctions. also indicates pyroptosis-dependent accelerates diabetes its frequent consequences including diabetic peripheral neuropathy (DPN). Pyroptosis-mediated reaction exacerbates DPN-mediated CNS injury. Accumulating shows molecular mechanisms trigger insulin-producing cells, development DPN. Numerous studies have suggested certain natural compounds or drugs possess promising pharmacological properties by modulating pyroptosis, thereby offering potential preventive practical therapeutic approaches for treatment management This review elaborates on underlying explores possible strategies regulating pyroptosis-regulated

Language: Английский

Citations

3
The m6A-ncRNAs axis in diabetes complications: novel mechanism and therapeutic potential DOI Creative Commons
Siming Yu, Chunsheng Li, Xinxin Lu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: June 24, 2024

Diabetes, a multifaceted metabolic disorder, poses significant global health burden with its increasing prevalence and associated complications, such as diabetic nephropathy, retinopathy, cardiomyopathy, angiopathy. Recent studies have highlighted the intricate interplay between N 6 -methyladenosine (m A) non-coding RNAs (ncRNAs) in key pathways implicated these diabetes like cell apoptosis, oxidative stress, inflammation. Thus, understanding mechanistic insights into how m A dysregulation impacts expression function of ncRNAs opens new avenues for therapeutic interventions targeting A-ncRNAs axis complications. This review explores regulatory roles modifications ncRNAs, stresses role A-ncRNA providing potential diseases.

Language: Английский

Citations

0