The dark side of light at night: physiological, epidemiological, and ecological consequences

Journal of Pineal Research, Journal Year: 2007, Volume and Issue: 43(3), P. 215 - 224

Published: June 25, 2007

Abstract: Organisms must adapt to the temporal characteristics of their surroundings successfully survive and reproduce. Variation in daily light cycle, for example, acts through endocrine neurobiological mechanisms control several downstream physiological behavioral processes. Interruptions normal circadian cycles resulting disruption melatonin rhythms cause widespread disruptive effects involving multiple body systems, results which can have serious medical consequences individuals, as well large‐scale ecological implications populations. With invention electrical lights about a century ago, organization environment has been drastically altered many species, including humans. In addition incidental exposure at night pollution, humans also engage increasing amounts shift‐work, repeated often long‐term disruption. The prevalence significant social, ecological, behavioral, health that are only now becoming apparent. This review addresses complicated web potential from night, may result.

Language: Английский

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Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia

FEBS Letters, Journal Year: 2006, Volume and Issue: 580(13), P. 2994 - 3005

Published: May 6, 2006

Mild to moderate hyperhomocysteinemia is a risk factor for neurodegenerative diseases. Human studies suggest that homocysteine (Hcy) plays role in brain damage, cognitive and memory decline. Numerous recent years investigated the of Hcy as cause damage. itself or folate vitamin B12 deficiency can disturbed methylation and/or redox potentials, thus promoting calcium influx, amyloid tau protein accumulation, apoptosis, neuronal death. The effect may also be mediated by activating N ‐methyl‐ d ‐aspartate receptor subtype. neurotoxic effects blocked folate, glutamate antagonists, various antioxidants. This review describes most important mechanisms neurotoxicity pharmacological agents known reverse effects.

Language: Английский

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Health Consequences of Circadian Disruption in Humans and Animal Models

Progress in molecular biology and translational science, Journal Year: 2013, Volume and Issue: unknown, P. 283 - 323

Published: Jan. 1, 2013

Language: Английский

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The Keap1-Nrf2-antioxidant response element pathway: A review of its regulation by melatonin and the proteasome

Molecular and Cellular Endocrinology, Journal Year: 2014, Volume and Issue: 401, P. 213 - 220

Published: Dec. 17, 2014

Language: Английский

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Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder

Cell Biochemistry and Function, Journal Year: 2002, Volume and Issue: 20(2), P. 171 - 175

Published: Jan. 18, 2002

Recent data from several reports indicate that free radicals are involved in aetiopathogenesis of many human pathologies including neuropsychiatric disorders such as schizophrenia, bipolar disorder etc. In the present study, we aimed at determining and evaluating levels malondialdehyde (MDA), a product lipid peroxidation, antioxidant enzyme superoxide dismutase (SOD) glutathione peroxidase (GSH-Px) activity patients diagnosed with schizophrenia (n = 25) 23). The control group was composed 20 healthy subjects. There significant increase MDA compared controls. SOD GSH-Px were significantly higher schizophrenic than controls whereas there no changes Significant differences between peroxidation (SOD GSH-Px) leads us to believe these related heterogenities aetiologies disorders.

Language: Английский

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Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin‐induced diabetes mellitus

Journal of Pineal Research, Journal Year: 2002, Volume and Issue: 32(4), P. 225 - 230

Published: April 30, 2002

There is a clearly documented link between diabetic complications and lipid peroxidation. Hyperglycemia causes reduction in levels of protective endogenous antioxidants increases generation free radicals. The present study was carried out to compare the effects melatonin vitamin E against streptozocin (STZ)‐induced diabetes rats. Melatonin administered s.c. (100 μ g/kg) whereas given i.p. mg/kg) after induction with STZ (60 mg/kg). Plasma total cholesterol, triglyceride low density lipoprotein (LDL) were increased group while both injection caused significant decrease all these parameters. lowering effect greater than that E. brain, liver kidney tissue malondialdehyde (MDA) which because STZ‐induced diabetes. Vitamin also reduced elevated MDA concentrations rat tissues, but more potent Furthermore, treatment rats brain glutathione peroxidase (GSH‐Px) activity below control found be less effective on GSH‐Px it liver. In summary, prevents many by reducing oxidative stress protects organisms from damage dyslipidemia. Considering much lower molar concentration compared E, seems antioxidant, especially kidney.

Language: Английский

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Effects of Melatonin on Liver Injuries and Diseases

International Journal of Molecular Sciences, Journal Year: 2017, Volume and Issue: 18(4), P. 673 - 673

Published: March 23, 2017

Liver injuries and diseases are serious health problems worldwide. Various factors, such as chemical pollutants, drugs, alcohol, could induce liver injuries. involve a wide range of pathologies, including hepatic steatosis, fatty liver, hepatitis, fibrosis, cirrhosis, hepatocarcinoma. Despite all the studies performed up to now, therapy choices for very few. Therefore, search new treatment that safely effectively block or reverse remains priority. Melatonin is well-known natural antioxidant, has many bioactivities. There numerous investigating effects melatonin on diseases, regulate various molecular pathways, inflammation, proliferation, apoptosis, metastasis, autophagy in different pathophysiological situations. be used preventing treating diseases. Herein, we conduct review summarizing potential roles paying special attention mechanisms action.

Language: Английский

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Biomarkers of oxidative status: missing tools in conservation physiology

Conservation Physiology, Journal Year: 2014, Volume and Issue: 2(1), P. cou014 - cou014

Published: May 12, 2014

Recent ecological studies have shown that oxidative status could a significant impact on fitness components in wild animals. Not only can reflect the environmental conditions animals experience, but it also predict their chances of reproduction and survival future natural habitat. Such important characteristics make markers informative tools to evaluate priori individual perspectives as well assess posteriori effect human activities species conservation concern wildlife general. Markers may therefore help practitioners identify threats animal populations maximize success management. Despite these potential benefits for programmes, up now been reported anecdotally studies. The aim this review is raise awareness by use status. Towards end, we first describe how disruptions due translate into variation Second, show population contribute or failure reintroduction translocation programmes. Finally, emphasize technical features specific measurement which investigators with interpretation results. prior knowledge about encourage physiologists them order enhance programmes

Language: Английский

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Daily rhythm of glutathione peroxidase activity, lipid peroxidation and glutathione levels in tissues of pinealectomized rats

Neuroscience Letters, Journal Year: 2002, Volume and Issue: 323(3), P. 195 - 198

Published: May 1, 2002

Language: Английский

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Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats

Free Radical Biology and Medicine, Journal Year: 2003, Volume and Issue: 35(7), P. 797 - 804

Published: Oct. 1, 2003

Language: Английский

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