Mapping Endocytic Vesicular Acidification with a pH‐Responsive DNA Nanomachine DOI Open Access
Xiaodong Xie, Zhiyuan Liu,

Xuelin Xiang

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: 25(22)

Published: Aug. 22, 2024

Mapping the endocytic vesicular acidification process is of prior importance to better understand health and pathological processes cells. Herein, by integrating a pH-sensitive i-motif pair fluorescence resonance energy transfer (FRET) into tetrahedral DNA framework (TDF), we develop pH-responsive nanomachine, allowing for efficient sensing pH from 7.0 5.5 via pH-triggered spatial proximity modulation FRET. The inheriting endo-lysosome-targeting ability TDF enables spatiotemporal tracking vesicle during endosomal maturation process. Analysis pH-dependent FRET response at single fluorescent spot level reveals significant difference between normal cancer performance nanomachine underlines its potential studies on acidification-related pathologies as universal platform.

Language: Английский

Organic fluorophores-based molecular probes with dual-fluorescence ratiometric responses to in-vitro/in-vivo pH for biosensing, bioimaging and biotherapeutics applications DOI
Rijun Gui, Hui Jin

Talanta, Journal Year: 2024, Volume and Issue: 275, P. 126171 - 126171

Published: April 28, 2024

Language: Английский

Citations

9
A pH-Resilient Fluorogenic Probe for Stable High-Resolution Imaging of Lysosomal Dynamics DOI

Xiangning Fang,

Guanyu Jiang, Qinglong Qiao

et al.

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112872 - 112872

Published: May 1, 2025

Language: Английский

Citations

0
Dual-emitting fluorescence ratiometric nanoprobes of in-vitro/in-vivo pH from constructions to sensing, imaging and therapeutic applications DOI
Rijun Gui, Hui Jin

Journal of Photochemistry and Photobiology C Photochemistry Reviews, Journal Year: 2023, Volume and Issue: 58, P. 100650 - 100650

Published: Dec. 31, 2023

Language: Английский

Citations

5
Mapping Endocytic Vesicular Acidification with a pH‐Responsive DNA Nanomachine DOI Open Access
Xiaodong Xie, Zhiyuan Liu,

Xuelin Xiang

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: 25(22)

Published: Aug. 22, 2024

Mapping the endocytic vesicular acidification process is of prior importance to better understand health and pathological processes cells. Herein, by integrating a pH-sensitive i-motif pair fluorescence resonance energy transfer (FRET) into tetrahedral DNA framework (TDF), we develop pH-responsive nanomachine, allowing for efficient sensing pH from 7.0 5.5 via pH-triggered spatial proximity modulation FRET. The inheriting endo-lysosome-targeting ability TDF enables spatiotemporal tracking vesicle during endosomal maturation process. Analysis pH-dependent FRET response at single fluorescent spot level reveals significant difference between normal cancer performance nanomachine underlines its potential studies on acidification-related pathologies as universal platform.

Language: Английский

Citations

0