Nitrobenzene and Aniline‐Mediated Direct Olefination of Methyl Substituted N‐Heteroarenes With Benzylic Alcohols DOI
Chunping Dong, Mei Xin,

Caijuan Hu

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(44)

Published: Nov. 1, 2024

Abstract Metal‐free, strong‐base‐free, and solvent‐free synthesis of alkenyl heteroarenes through PhNO 2 /PhNH mediated direct olefination methyl substituted N ‐heteroarenes with benzylic alcohols was described. Detailed mechanistic studies indicated that in situ formed imine the active intermediate for olefination. protected from overoxidation, PhNH not only acted as coupling partner formation imine, but also provides an alkaline condition generation enamine salt. Gram scale reaction three pharmaceutically relevant conjugated olefins were successful using this methodology.

Language: Английский

Temperature-dependent switchable synthesis of imines and amines via coupling of alcohols and amines using pyrrolyl-imine ruthenium catalysts DOI
Qing Li, Yu Hou,

Mengxuan Bai

et al.

Journal of Catalysis, Journal Year: 2024, Volume and Issue: unknown, P. 115895 - 115895

Published: Dec. 1, 2024

Language: Английский

Citations

3
Dioxygen Controlled Chemodivergent Cross‐Coupling of Primary and Secondary Alcohols Using Noninnocent Azo Aromatic Complexes of Cobalt(II) as Catalysts DOI Open Access

kamal kamal,

Subhas Samanta

ChemCatChem, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

Abstract Herein, employing pincer like cobalt (II) complexes containing redox noninnocent azo‐benzimidazole ligand a switchable and chemodivergent catalytic cross‐coupling of primary secondary alcohols is reported. The reactions are environmentally benign atom efficient. It liberates water hydrogen gas as the only byproducts. While reaction in inert condition gives alkylated ketones, presence air well lower temperature base loading selectively results unsaturated ketones. Both protocols have very good functional group tolerance. Thus, wide range substrates been found to be effective for synthesis ketones via dehydrogenative alcohols. Several control experiments kinetic studies were performed elucidate pathways.

Language: Английский

Citations

2
Nitrobenzene and Aniline‐Mediated Direct Olefination of Methyl Substituted N‐Heteroarenes With Benzylic Alcohols DOI
Chunping Dong, Mei Xin,

Caijuan Hu

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(44)

Published: Nov. 1, 2024

Abstract Metal‐free, strong‐base‐free, and solvent‐free synthesis of alkenyl heteroarenes through PhNO 2 /PhNH mediated direct olefination methyl substituted N ‐heteroarenes with benzylic alcohols was described. Detailed mechanistic studies indicated that in situ formed imine the active intermediate for olefination. protected from overoxidation, PhNH not only acted as coupling partner formation imine, but also provides an alkaline condition generation enamine salt. Gram scale reaction three pharmaceutically relevant conjugated olefins were successful using this methodology.

Language: Английский

Citations

0