J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: April 22, 2021

Abstract J-aggregation is an efficient strategy for the development of fluorescent imaging agents in second near-infrared window. However, design J-aggregates challenging due to lack suitable dyes. Herein, we report meso -[2.2]paracyclophanyl-3,5-bis- N , -dimethylaminostyrl BODIPY (PCP-BDP2) as example dye with induced fluorescence. PCP-BDP2 shows emission maximum at 1010 nm state. Mechanism studies reveal that steric and conjugation effect PCP group on play key roles behavior photophysical properties tuning. Notably, can be utilized lymph node fluorescence-guided surgery nude mouse, which demonstrates their potential clinical application. This study alternate platform developing agents.

Language: Английский

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BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(18)

Published: Nov. 18, 2022

Abstract The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, inspiring cutting‐edge work post‐functionalization highlighted. A brief overview assembly model BODIPY then provided: introduced as a promising building block for the formation single‐ multicomponent self‐assembled systems, including nanostructures suitable aqueous environments, thereby showing great development potential supramolecular applications. frontier progress biomedical application thereafter described, supported by examples frontiers applications BODIPY‐containing smart materials: it mainly involves materials based on blocks their assemblies fluorescence bioimaging, photoacoustic imaging, disease treatment photodynamic therapy, photothermal immunotherapy. Lastly, not only current status family field but also challenges worth considering summarized. At same time, insights into future prospects biomedically applicable provided.

Language: Английский

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Direct Quantification and Visualization of Homocysteine, Cysteine, and Glutathione in Alzheimer’s and Parkinson’s Disease Model Tissues

Analytical Chemistry, Journal Year: 2021, Volume and Issue: 93(28), P. 9878 - 9886

Published: July 7, 2021

Alzheimer's disease (AD) and Parkinson's (PD) are chronic neurodegenerative diseases with high morbidity mortality. Homocysteine (Hcy), cysteine (Cys), glutathione (GSH) closely related to AD PD. However, the dynamics of Hcy, Cys, GSH in brain tissues potential pathogenesis between Cys/Hcy/GSH PD remain unclear. Herein, a novel fluorescent probe 1 multiple binding sites was rationally designed exploited for direct quantification serum total Hcy Cys along superior optical properties. Importantly, differentiation simultaneity fluorescence imaging were achieved living cells, tissues, mouse models this probe, providing evidences relationship Hcy/Cys/GSH AD/PD first time. In addition, studies demonstrated that elevated levels imbalanced redox homeostasis, increased amyloid aggregates, nerve cell cytotoxicity. These findings will greatly promote understanding functions diseases, demonstrating clinical promise early diagnosis prevention

Language: Английский

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BODIPY-based fluorescent probe for cysteine detection and its applications in food analysis, test strips and biological imaging

Food Chemistry, Journal Year: 2023, Volume and Issue: 416, P. 135730 - 135730

Published: Feb. 18, 2023

Language: Английский

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ONOO–-activatable and LD-traced NIR fluorescent probe for mechanism study and early diagnosis of NAFLD and diabetes induced liver injury

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 412, P. 135806 - 135806

Published: April 10, 2024

Language: Английский

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Recent advances in the design of organic photothermal agents for cancer treatment: A review

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215719 - 215719

Published: Feb. 24, 2024

Language: Английский

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Fluorescent Probe for Simultaneous Discrimination of GSH, Cys, and SO₂ Derivatives

Analytical Chemistry, Journal Year: 2020, Volume and Issue: 92(15), P. 10800 - 10806

Published: July 1, 2020

Biothiols and SO2 derivatives, as essential reactive sulfur species (RSS), play vital roles in various physiological processes have a close network of generation metabolic pathways among them. To clarify their complex correlations, fluorescent probes to simultaneously detect GSH, Cys, derivatives are highly desirable. Herein, we develop the first probe (BO-HEM) discriminate derivatives. The is designed by integration hemicyanine BODIPY fluorophores through an ether bond. bond rapidly replaced thiolates nucleophilic aromatic substitution (SNAr) generate with NIR fluorescence sulfur-BODIPY. amino groups Cys but not GSH then further replace thiolate form amino-BODIPY. As for SO32–, addition double BO-HEM generates adduct O-BODIPY green fluorescence. improve sensing performance, nanoprobe increased reactivity biocompatibility constructed encapsulation into polymeric micelle. More importantly, taking advantage hydrophilicity reaction products, spectral discrimination was enhanced avoid signal interference. applied biothiols living cells three-color imaging.

Language: Английский

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The chronological evolution of small organic molecular fluorescent probes for thiols

Chemical Science, Journal Year: 2020, Volume and Issue: 12(4), P. 1220 - 1226

Published: Dec. 15, 2020

The chronological evolution of small organic molecular fluorescent probes for thiols: from separation dependency analysis to cellular specific analysis, what's next?

Language: Английский

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Endogenous peroxynitrite activated fluorescent probe for revealing anti‐tuberculosis drug induced hepatotoxicity

Chinese Chemical Letters, Journal Year: 2021, Volume and Issue: 33(3), P. 1584 - 1588

Published: Sept. 17, 2021

Language: Английский

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State of the Art of Bodipy‐Based Photocatalysts in Organic Synthesis

European Journal of Organic Chemistry, Journal Year: 2020, Volume and Issue: 2021(12), P. 1809 - 1824

Published: Dec. 25, 2020

Abstract Photochemistry is a tremendous research field offering many synthetic possibilities to chemists. Breakthroughs in this area have been notably driven by the implementation of new classes photocatalysts. Within context, Bodipy (Boron‐dipyrromethene) dyes possess attractive chemical and physical features such as their modularity, strong absorption under visible light irradiation, good thermal photochemical stabilities, high fluorescence quantum yields. As such, class compounds has found widespread applications functionalized materials, biology, medicine, or organic chemistry. From an organic‐synthetic point view, excited states harnessed electron energy transfer reactions. This minireview collates relevant literature on these catalysts photochemistry provides some perspectives area.

Language: Английский

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