1H-1,2,3-Triazol-5-ylidenes as Catalytic Organic Single-Electron Reductants

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(5), P. 2933 - 2938

Published: Jan. 22, 2024

Most of the known single-electron reductants are either metal based reagents, used in a stoichiometric amount, or combination an organic species and photocatalyst. Here we report that 1

Language: Английский

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Dinuclear NHC–gold(i)–thiolato and –alkynyl complexes: synthesis, anticancer activity, and catalytic activity in lactonization reactions

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(18), P. 7939 - 7945

Published: Jan. 1, 2024

A series of novel dinuclear NHC–gold–thiolato and –alkynyl complexes bearing aromatic linkers were successfully synthesized by an efficient simple synthetic route.

Language: Английский

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Antibody Drug Conjugates for Cancer Therapy: From Metallodrugs to Nature-Inspired Payloads

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8651 - 8651

Published: Aug. 8, 2024

This review highlights significant advancements in antibody–drug conjugates (ADCs) equipped with metal-based and nature-inspired payloads, focusing on synthetic strategies for antibody conjugation. Traditional methods such us maleimide succinimide conjugation classical condensation reactions are prevalent metallodrugs natural compounds. However, emerging non-conventional as photoconjugation gaining traction due to their milder conditions and, an aspect which minimizes side reactions, selective formation of ADC. The also summarizes the therapeutic diagnostic properties these ADCs, highlighting enhanced selectivity reduced effects cancer treatment compared non-conjugated payloads. ADCs combine specificity monoclonal antibodies cytotoxicity chemotherapy drugs, offering a targeted approach elimination cells while sparing healthy tissues. mechanism has demonstrated impressive clinical efficacy various malignancies. Key future include improved linker technology stability controlled release cytotoxic agents, incorporation novel, more potent, identification new cancer-specific antigens through genomic proteomic technologies. expected play crucial role combination therapies immune checkpoint inhibitors, CAR-T cells, small molecule leading durable potentially curative outcomes. Ongoing research trials expanding capabilities, paving way effective, safer, personalized treatments, positioning cornerstone modern medicine hope patients.

Language: Английский

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Fluorinated Biphenyl Phosphine Ligands for Accelerated [Au(I)]-Catalysis

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(8), P. 6128 - 6136

Published: April 8, 2024

Fluorinated JohnPhos-type ligands are proposed as accelerating tools in homogeneous gold(I) catalysis, with PedroPhosAuCl (Cat1) the most efficient one. The well corresponding gold complexes were synthesized high yields and fully characterized also via single-crystal X-ray diffraction. A secondary interaction between distal phenyl ring of phosphane ligand metal center is identified key for fine-tuning overall catalytic performance complexes. In particular, kinetic computational analysis revealed that by accommodating F atoms on biphenyl pendant ligand, more reactive organo-gold intermediates realized toward subsequent nucleophilic condensations. gold-catalyzed indole-hydroarylation 1,6-enynes intramolecular hydroindolynation alkynes have been adopted benchmark reactions to exemplify these effects.

Language: Английский

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Stepwise alkyne insertion in Au(i) acetylides: influence of the nuclearity

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The influence of the second metal atom in neutral σ,σ bimetallic gold( i ) acetylides is studied detail context migratory insertion a number substrates, where reaction conditions depend dramatically on nuclearity.

Language: Английский

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Gold(I) complexes with NHC ligands functionalized with sulfoxide groups: Design, synthesis, in vitro studies and insights into the mechanism of action as anticancer drugs

Journal of Inorganic Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 112957 - 112957

Published: May 1, 2025

Language: Английский

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Facile synthesis and bonding of 4-ferrocenyl-1,2,4-triazol-5-ylidene complexes

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(27), P. 11445 - 11453

Published: Jan. 1, 2024

Triazolium salt obtained by alkylation of 4-ferrocenyl-4 H -1,2,4-triazole reacts smoothly with metal hydroxides and alkoxides to produce 4-ferrocenyl-1,2,4-triazol-5-ylidene complexes, whose bonding was studied experimentally theoretically.

Language: Английский

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Comparative study of the antiproliferative activity of heterometallic carbene gold(i)–platinum(ii) and gold(i)–palladium(ii) complexes in cancer cell lines

Chemical Science, Journal Year: 2024, Volume and Issue: 15(37), P. 15291 - 15298

Published: Jan. 1, 2024

The stepwise, one-pot synthesis of heterobimetallic carbene gold( i ) platinum( ii complexes from readily available starting materials is presented and their cytotoxic properties are evaluated.

Language: Английский

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Silver and ruthenium complexes with anthracene functionalized N-heterocyclic carbene ligands: catalytic and cytotoxicity properties

Transition Metal Chemistry, Journal Year: 2024, Volume and Issue: 49(5), P. 365 - 372

Published: June 24, 2024

Language: Английский

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Palladium(II)-Indenyl Complexes Bearing N-Heterocyclic Carbene (NHC) Ligands as Potent and Selective Metallodrugs toward High-Grade Serous Ovarian Cancer Models

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(16), P. 14414 - 14431

Published: Aug. 9, 2024

In this study, we synthesized novel Pd(II)-indenyl complexes using various

Language: Английский

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