Photodynamic Inactivation of Bacteria Using Nickel(II) Complexes with Catecholate and Phenanthroline Ligands DOI Open Access

Raval Devraj Prakashchandra,

Rohit Rai,

Arif Ali Mandal

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: 26(1)

Published: Nov. 20, 2024

Abstract Metal complexes activated by light can combat infections triggering the photodynamic inactivation of bacteria. Herein, we report six mixed‐ligand nickel(II) with formulation [Ni(NN) 2 (L)] ( 1 – 6 ), where NN represents an N,N‐donor phenanthroline ligand, specifically 1,10‐phenanthroline (phen in , dipyrido[3,2‐d:2’,3’‐f]quinoxaline (dpq 3 4 and dipyrido[3,2‐a:2’,3’‐c]phenazine (dppz 5 while L is O,O donor bidentate ligand derived from catechol (cat 2− ) or esculetin (esc ). The paramagnetic d 8 octahedral demonstrated good dark photostability solution phase exhibited significant absorption visible (400–700 nm) region. When exposed to low‐energy light, these activity against both Gram‐(+) Staphylococcus aureus S. Gram‐(−) Escherichia coli E. This resulted minimum inhibitory concentration (MIC) values ranging 0.31–9.49 μM. was caused cell‐damaging singlet oxygen species produced under exposure. Notably, showed no bacterial inhibition conditions. study marks first examples Ni(II) designed for light‐triggered antibacterial activity, illuminating path Ni(II)‐based non‐macrocyclic PDT applications.

Language: Английский

Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria DOI
Ling‐Min Pei, Xiaolin Yu, Xiaoyu Shan

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 29, 2025

The rise of antibiotic-resistant Gram-positive bacterial infections poses a significant threat to public health, necessitating the exploration alternative therapeutic strategies. A photosensitizer (PS) can convert energy from absorbed photon into reactive oxygen species (ROS) for damaging bacteria. This photoinactivation action bypassing conventional antibiotic mechanism is less prone resistance development, making antibacterial photodynamic therapy (aPDT) highly efficient in combating Photodynamic transition metal complexes leveraging unique properties metals enhance aPDT activity are next-generation PS. review provides an overview metal-based PS Based on structures, these metal-PS could be mainly classified as metal-tetrapyrrole derivatives, ruthenium complexes, iridium and zinc complexes. based other such silver, cobalt, rhenium also presented. Finally, we summarize advantages shortcomings metal- PS, conclude some critical aspects impacting their performances give perspective future development.

Language: Английский

Citations

0
Luminescent iridium(III) complexes with nitrogen-rich 1,2,3-triazoles: Synthesis, photophysics and electrochemistry DOI
Soumik Mandal, Bishnu Das, Parna Gupta

et al.

Journal of Coordination Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Feb. 25, 2025

Language: Английский

Citations

0
Development of Cyclometalated Iridium(III) Complexes of 2‐Phenylbenzimidazole and Bipyridine Ligands for Selective Elimination of Gram‐Positive Bacteria DOI

Aryan Gautam,

Ajay Gupta, Puja Prasad

et al.

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Abstract Herein, we have reported a series of cationic aggregation‐induced emission (AIE) active iridium(III) complexes ( Ir1‐Ir5 ) the type [Ir(C N) 2 (N N)]Cl, wherein C N is cyclometalating 2‐phenylbenzimidazole ligand with varying alkyl chain lengths and 2,2’‐bipyridine attached to bis‐polyethylene glycol chains, for treatment bacterial infections. The AIE phenomenon leveraged detecting bacteria by fluorescence microscopy imaging that displayed strong red in Gram‐positive bacteria. antibacterial activity assessed against methicillin‐sensitive S. aureus , methicillin‐resistant E. faecium faecalis Gram‐negative coli P. aeruginosa clinical interest. Ir2‐Ir4 exerted potent towards strains low minimum inhibitory concentrations (MICs) values range 1–9 μM, which comparable clinically approved antibiotic vancomycin. In contrast, these were found be inactive (MICs >100 μM). mechanism implies ROS generation, membrane depolarization rupture are responsible cell death. Further, Ir1‐Ir3 low‐toxic human blood cells embryonic kidney (HEK293) cells, indicating their potential use as agents.

Language: Английский

Citations

1
Modulatory Role of Pantropic Cell Signaling Pathways in the Antimigratory and Antiproliferative Action of Triazole Chelated Iridium(III) Complexes in Cervical Cancer Cells DOI
Anushka Mondal, Bishnu Das, Souvik Karmakar

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(22), P. 20559 - 20570

Published: Nov. 11, 2024

In the current study, antimigratory and antiproliferative effect of three substituted triazole-chelated iridium(III) complexes Ir-TRN, Ir-TRH, Ir-TRF were studied with special emphasis on modulation P53 activity, a cell cycle regulator. ERK2/MAPK, another crucial signaling pathway protein, was also shown to play role in migration proliferation. The increase ROS generation within cell, further supporting apoptotic induction by exerting cellular oxidative stress. These metal affect ER stress altering ERp29, an ER-resident chaperone, inducing process apoptosis. restrict cervical cancer proliferation pronounced effects as activators downregulation ERK2/MAPK activity cells. underpinning mechanism cells presence detail this which paves way for developing promising avenues therapeutics.

Language: Английский

Citations

1
Transition Metal Complex‐Loaded Nanosystems: Advances in Stimuli‐Responsive Cancer Therapies DOI Creative Commons
Bishnu Das

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Transition metal complex-loaded nanosystems (TMCNs) represent a cutting-edge platform for stimuli (light, ultrasound)-responsive cancer therapies. These nanosystems, incorporating metals such as manganese(II), zinc(II), ruthenium(II), rhenium(I), iridium(III), and platinum(IV), significantly enhance the efficacy of light-activated therapies, including photodynamic therapy (PDT) photothermal (PTT), well ultrasound-activated treatments like sonodynamic (SDT). TMCNs based on iridium(III) improve PDT, while manganese(II) demonstrate exceptional sonosensitizing properties. In PTT, ruthenium(II) iridium(III)-based efficiently absorb light generate heat. Emerging synergistic approaches that combine SDT, chemotherapy, immunotherapy are demonstrated to be powerful strategies precision treatment. Zinc(II), platinum(IV)-based play critical role in optimizing these enhancing tumor targeting, reducing side effects. Furthermore, can amplify by inducing immunogenic cell death, thus strengthening immune response. advances address key challenges hypoxia therapeutic resistance, opening new possibilities innovative photosensitizer-based treatments. This review highlights latest progress design applications, demonstrating their potential revolutionize stimuli-responsive

Language: Английский

Citations

1
Photodynamic Inactivation of Bacteria Using Nickel(II) Complexes with Catecholate and Phenanthroline Ligands DOI Open Access

Raval Devraj Prakashchandra,

Rohit Rai,

Arif Ali Mandal

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: 26(1)

Published: Nov. 20, 2024

Abstract Metal complexes activated by light can combat infections triggering the photodynamic inactivation of bacteria. Herein, we report six mixed‐ligand nickel(II) with formulation [Ni(NN) 2 (L)] ( 1 – 6 ), where NN represents an N,N‐donor phenanthroline ligand, specifically 1,10‐phenanthroline (phen in , dipyrido[3,2‐d:2’,3’‐f]quinoxaline (dpq 3 4 and dipyrido[3,2‐a:2’,3’‐c]phenazine (dppz 5 while L is O,O donor bidentate ligand derived from catechol (cat 2− ) or esculetin (esc ). The paramagnetic d 8 octahedral demonstrated good dark photostability solution phase exhibited significant absorption visible (400–700 nm) region. When exposed to low‐energy light, these activity against both Gram‐(+) Staphylococcus aureus S. Gram‐(−) Escherichia coli E. This resulted minimum inhibitory concentration (MIC) values ranging 0.31–9.49 μM. was caused cell‐damaging singlet oxygen species produced under exposure. Notably, showed no bacterial inhibition conditions. study marks first examples Ni(II) designed for light‐triggered antibacterial activity, illuminating path Ni(II)‐based non‐macrocyclic PDT applications.

Language: Английский

Citations

0