Synthesis and Characterization of Gold Chiral Nanoparticles Functionalized by a Chiral Drug

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(9), P. 1526 - 1526

Published: April 30, 2023

Inorganic chiral nanoparticles are attracting more and attention due to their peculiar optical properties potential biological applications, such as bioimaging, therapeutics, diagnostics. Among inorganic nanoparticles, gold nanostructures were demonstrated be very interesting in this context, with good physical chemical stability also the possibility decorate surface, improving biomedical application interaction bio-systems. Gold (Au) synthesized according a seed-mediated procedure which envisages use of cetyltrimethylammonium bromide (CTAB) capping agent L- D-cysteine promote chirality. Au have been opposite circular dichroism signals depending on amino acid enantiomer used during synthesis. Then, surface penicillamine, drug for treatment Wilson's disease, was developed. The composite material nanoparticles/penicillamine characterized using electron microscopy, penicillamine functionalization monitored by means UV-Visible, Raman, infrared spectroscopy, highlighting formation Au-S bond. Furthermore, monitor chirality it that both enantiomers can successfully bonded without affecting nanoparticles' effective modification nanostructures' surfaces via introduction allowed us address important issue controlling nano-system.

Language: Английский

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Multiscale Chiral Synthesis via Self-Assembly of Achiral Nanoparticles for Next-Generation Chiral Material-Based Applications: The Role of Metal Ions as Chirality Messengers

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(21), P. 19632 - 19638

Published: Oct. 19, 2023

Chiroptical activity over a broad range is expected to enable numerous applications including bioimaging and nanothermometers. However, understanding the chemical mechanism behind producing multiscale chirality for chiroptical activities remains challenging. Here, we present simple chiral synthesis elucidate underlying self-assembly of achiral copper sulfide nanoparticles (NPs). The initially NPs assemble into anisotropically twisted structures with distinct handedness depending on molecules in solution. Importantly, reveal first time, our knowledge, that metal ions act as messengers transfer information from small microstructures. resulting exhibit strong ranging ultraviolet infrared. This study not only enhances but also offers effective approaches inorganic materials next-generation material-based applications.

Language: Английский

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Synthesis of Chiral Substituted meta ‐Bromoanilines as Ligands for Copper-Catalyzed Asymmetric Aldol Addition Reactions

Organic Preparations and Procedures International, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Sept. 9, 2024

Language: Английский

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Chiral nanomaterials for neurodegenerative diseases

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(2), P. 89 - 102

Published: May 8, 2024

Chiral nanomaterials with distinctive physical and chemical properties, including circular dichroism, circularly polarized photoluminescence, nonlinear optics, spintronics, have risen to the forefront of materials science research, remarkable potential for applications in drug delivery disease diagnosis treatment. In recent years, increasing attention has been drawn application chiral study treatment neurodegenerative diseases, mainly due their stereoselective interactions biomolecules, such as DNA, amino acids, peptides, which are also chiral. Although there some good reviews biological nanomaterials, little in-depth discussion diseases date. Thus, progress was summarized discussed this review. Firstly, classification, preparation methods characteristics were described. The subsequent focused on mechanism diseases. Moreover, current challenges future prospects filed thoroughly discussed. This review will provide valuable insights guidance construction that possess specific functions alleviating progression

Language: Английский

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A dicoumarol-graphene oxide quantum dot polymer inhibits porcine reproductive and respiratory syndrome virus through the JAK-STAT signaling pathway

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: June 19, 2024

Introduction Porcine reproductive and respiratory syndrome virus (PRRSV) causes substantial economic losses in the global swine industry. The current vaccine options offer limited protection against PRRSV transmission, there are no effective commercial antivirals available. Therefore, is an urgent need to develop new antiviral strategies that slow transmission. Methods In this study, we synthesized a dicoumarol-graphene oxide quantum dot (DIC-GQD) polymer with excellent biocompatibility. This was via electrostatic adsorption method using natural drug DIC GQDs as raw materials. Results Our findings demonstrated exhibits high anti-PRRSV activity by inhibiting replication stage. transcriptome sequencing analysis revealed treatment stimulates genes associated Janus kinase/signal transducer activator of transcription (JAK/STAT) signalling pathway. porcine alveolar macrophages (PAMs), DIC-GQDs induce TYK2, JAK1, STAT1, STAT2 phosphorylation, leading upregulation STAT2, interferon-β (IFN-β) interferon-stimulated (ISGs). Animal challenge experiments further confirmed effectively alleviated clinical symptoms pathological reactions lungs, spleen, lymph nodes PRRSV-infected pigs. Discussion These suggest significantly inhibits proliferation activating JAK/STAT hold promise alternative for infection.

Language: Английский

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