Frontiers in Chemistry,
Journal Year:
2022,
Volume and Issue:
10
Published: Nov. 29, 2022
We
reported
a
general
transition
metal-free
transformation
to
access
C3-carbamoylated
2H-indazoles
via
visible
light-induced
oxidative
decarboxylation
coupling,
in
the
presence
of
oxamic
acids
as
coupling
sources,
4CzIPN
photocatalyst,
and
Cs2CO3
base.
The
great
application
potential
this
mild
condition
is
highlighted
by
late-stage
modification
drugs,
N-terminal
peptides,
good
antitumor
activity
novel
desired
product.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(20), P. 7971 - 7977
Published: Jan. 1, 2023
Alkyl
diacyl
peroxides
were
demonstrated
to
be
efficient
alkylating
reagents
for
the
visible-light-induced
4CzIPN-catalyzed
direct
C–H
alkylation
of
N
-heteroaromatics.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(12), P. 7331 - 7336
Published: Jan. 1, 2024
A
novel
photocatalytic
acylation
strategy
was
developed
harnessing
tetrabutylammonium
decatungstate
(TBADT)
as
a
hydrogen
atom
transfer
(HAT)
photocatalyst
to
facilitate
the
direct
coupling
of
aldehydes
with
N-heterocycles
at
ambient
temperature.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(21), P. 11530 - 11536
Published: May 16, 2023
Because
of
its
impressive
ability
to
promote
pharmaceutical
activity,
the
introduction
trifluoromethylacyl
(CF3CO)
functionality
into
organic
compounds
has
become
an
important
and
growing
research
area.
Although
various
protocols
have
been
developed
access
trifluoroketones,
use
trifluoroacetyl
radicals
remains
virtually
undeveloped.
Herein,
we
disclose
a
novel
method
for
trifluoroacetylation
through
umpolung
reagent,
thereby
transforming
electrophilic
radical
nucleophilic
radical.
The
applicability
this
transformation
is
highlighted
by
large-scale,
late-stage
reactions
complex
bioactive
molecules
sclareolide
loratadine.
Furthermore,
direct
trifluoromethyl
ketones
fluorinated
analogues
illustrates
potential
synthetic
application
our
method.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(45), P. 8265 - 8270
Published: Nov. 7, 2022
The
greener
synthesis
of
N-substituted
isonicotinamides
is
high
importance
and
remains
a
significant
challenge
to
the
chemistry
community.
Herein
we
delineated
visible-light-driven,
transition-metal-free,
external-oxidant-free
radical-radical
cross-coupling
reaction
access
via
consecutive
photoinduced
electron
transfer
(ConPET).
utility
this
protocol
highlighted
through
N-terminal
modification
peptides
late-stage
drugs.
Tetrahedron Chem,
Journal Year:
2024,
Volume and Issue:
10, P. 100073 - 100073
Published: April 16, 2024
A
protocol
based
on
photocatalytic
cycles
of
both
iron(III)chloride
and
9,10-dicyanoanthracene
(DCA)
is
developed
for
the
masked
hydroformylation,
hydroacylation,
hydrocarboxylation
Michael-Acceptors
utilizing
readily
available
1,3,5-trioxanes.
Initiated
by
LMCT
[FeCl4]–
to
generate
chlorine
radicals
that
promote
hydrogen
atom
transfer
(HAT)
from
trioxanes,
used
as
co-photocatalyst
accelerate
formation
desired
products
facilitating
reoxidation
iron(II)
iron(III).
The
methodology
robust,
allowing
generation
aldehydes,
ketones,
carboxylic
acids
either
altering
trioxane
deprotection
strategy
or
subsequent
photocatalyzed
conversion
initially
obtained
aldehydes.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(4), P. 2741 - 2747
Published: Feb. 1, 2024
Acyl
radicals
have
been
generated
from
the
decarboxylation
of
α-oxocarboxylic
acids
by
using
a
readily
accessible
organic
pyrimidopteridine
photoredox
catalyst
under
ultraviolet-A
(UV-A)
light
irradiation.
These
reactive
acyl
were
smoothly
added
to
olefins
such
as
styrenes
and
diverse
Michael
acceptors,
with
assistance
H2O/D2O
hydrogen
donors,
enabling
easy
access
range
ketones/β-deuterio
ketones.
A
wide
are
compatible
this
reaction,
which
shows
reliable,
atom-economical,
eco-friendly
protocol.
Furthermore,
postsynthetic
diversifications
applications
presented.
