Approach of a small protein to the biomimetic bis-(μ-oxo) dicopper active-site installed in MOF-808 pores with restricted access perturbs substrate selectivity of oxidase nanozyme DOI Creative Commons

Rasmi V. Morajkar,

Adarsh P. Fatrekar,

Amit A. Vernekar

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(28), P. 10810 - 10822

Published: Jan. 1, 2024

Development of substrate-selective nanozyme requires careful attention. We show that proteins with dimensions larger than the pore aperture MOF-808, installed a bis-(μ-oxo) dicopper active site in its adamantane pore, can compromise substrate selectivity oxidase nanozyme.

Language: Английский

Nanozymes: Potential Therapies for Reactive Oxygen Species Overproduction and Inflammation in Ischemic Stroke and Traumatic Brain Injury DOI
Yunfan Yang, Zi-Xiang Li, Xiaochong Fan

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16450 - 16467

Published: June 19, 2024

Nanozymes, which can selectively scavenge reactive oxygen species (ROS), have recently emerged as promising candidates for treating ischemic stroke and traumatic brain injury (TBI) in preclinical models. ROS overproduction during the early phase of these diseases leads to oxidative damage, has been a major cause mortality worldwide. However, clinical application ROS-scavenging enzymes is limited by their short vivo half-life inability cross blood-brain barrier. mimic catalytic function natural enzymes, several advantages, including cost-effectiveness, high stability, easy storage. These advantages render them superior disease diagnosis therapeutic interventions. This review highlights recent advancements nanozyme applications TBI, emphasizing potential mitigate detrimental effect overproduction, inflammation, barrier compromise. Therefore, nanozymes represent treatment modality conditions future medical practices.

Language: Английский

Citations

12
Peptide nanozymes: An emerging direction for functional enzyme mimics DOI
Shao‐Bin He,

Long Ma,

Qionghua Zheng

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 42, P. 284 - 298

Published: Sept. 4, 2024

Language: Английский

Citations

12
Prospects for the use of nanozyme-based electrochemical and colorimetric sensors for antibiotic detection DOI
О. I. Guliy, Л. А. Дыкман

Talanta, Journal Year: 2025, Volume and Issue: 286, P. 127524 - 127524

Published: Jan. 7, 2025

Language: Английский

Citations

1
Metal-organic framework-based nanozymes for water-soluble antioxidants and Total antioxidant capacity detection: Principles and applications DOI
Sameera Sh. Mohammed Ameen, Khalid M. Omer

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 143876 - 143876

Published: March 1, 2025

Language: Английский

Citations

1
Spatially Decoupled H2O2 Activation Pathways and Multi‐Enzyme Activities in Rod‐Shaped CeO2 with Implications for Facet Distribution DOI Creative Commons
Tianqi Cheng, Xinyu Wu, Yuwei Qiu

et al.

Small, Journal Year: 2024, Volume and Issue: 20(34)

Published: April 15, 2024

Abstract CeO 2 , particularly in the shape of rod, has recently gained considerable attention for its ability to mimic peroxidase (POD) and haloperoxidase (HPO). However, this multi‐enzyme activities unavoidably compete H O affecting performance relevant applications. The lack consensus on facet distribution rod‐shaped further complicates establishment structure‐activity correlations, presenting challenges progress field. In study, HPO‐like activity is successfully enhanced while maintaining POD‐like through a facile post‐calcination method. By studying spatial these two their exclusive activation pathways surfaces, study finds that increased originated from newly exposed (111) surface at tip shortened rods after calcination, unchanged attributed retained (110) lateral area. These findings not only address discrepancies commonly reported literature but also offer simple approach enhance antibacterial performance. This work expected provide atomic insights into catalytic correlations guide design nanozymes with improved reaction specificity.

Language: Английский

Citations

7
Multifunctional Fe/Cu Dual-Single Atom Nanozymes with Enhanced Peroxidase Activity for Isoniazid Detection and Levofloxacin Degradation DOI

Xiaoyi Xie,

Yan Zhao,

Yuxiu Fan

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(24), P. 12671 - 12680

Published: June 10, 2024

The design of single-atom nanozymes with dual active sites to increase their activity and for the detection degradation contaminants is rare challenging. In this work, a nanozyme (FeCu-NC) based on three-dimensional porous Fe/Cu site was developed as colorimetric sensor both quantitative analysis isoniazid (INH) efficient levofloxacin (LEV). FeCu-NC synthesized using salt template freeze-drying method hollow structure (Fe–Nx Cu–Nx). terms morphology structure, exhibits excellent peroxidase-like catalytic properties. Therefore, constructed around sensitive rapid INH linear range 0.9–10 μM limit low 0.3 μM, successfully applied in human urine. addition, promoted LEV by peroxymonosulfate activation, rate 90.4% at 30 min. This work sheds new light application antibiotics sensing degradation.

Language: Английский

Citations

4
Surface Au–H Species as Self-Generated Prosthetic Groups of a Formate Dehydrogenase-like Au Nanozyme to Engineer Multienzymatic Activities DOI
Xu Li,

Wenlong Tan,

Jinsong Fan

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(35), P. 24162 - 24172

Published: Aug. 20, 2024

Although the past decade has witnessed a rapid development of oxidoreductase-mimicking nanozymes, mimicry cofactors that play key roles in mediating electron and proton transfer remains limited. This study explores how surface Au-H species conjugated to Au nanoparticles (NPs) imitate formate dehydrogenase (FDH) can serve as cofactors, analogous NADH natural enzymes, offering diverse possibilities for FDH-mimicking nanozymes mimic various enzymes. Once O

Language: Английский

Citations

4
Thiourea enhanced oxidase-like activity of CeO2/CuxO nanozyme for fluorescence/colorimetric detection of thiourea and glutathione DOI
Weiwei Chen, Tao Wu,

Siyuan Wei

et al.

Talanta, Journal Year: 2024, Volume and Issue: unknown, P. 126868 - 126868

Published: Sept. 1, 2024

Language: Английский

Citations

4
Oxidase mimicking nanozyme based sensors: From classification and catalytic mechanisms to food safety applications DOI
Mohammed Asiri, Ayad Abdulrazzaq Mutar, Enwa Felix Oghenemaro

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112640 - 112640

Published: Jan. 1, 2025

Language: Английский

Citations

0
Selenium-Doped Copper Formate Nanozymes with Antisenescence and Oxidative Stress Reduction for Atherosclerosis Treatment DOI

Xiao Huang,

Yue Zhou, Yun Guo

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Atherosclerosis, resulting from chronic inflammation of the arterial wall, serves as underlying cause multiple major cardiovascular diseases. Current anti-inflammatory therapies often exhibit limited and unsatisfactory efficacy. To address this, we have designed a selenium-doped copper formate (Cuf-Se) nanozyme for treatment atherosclerosis, which possesses superoxide dismutase (SOD) glutathione peroxidase (GPx)-like activities. The Cuf-Se can efficiently scavenge reactive oxygen species (ROS), inhibit cellular senescence, prevent formation foam cells. It acts on macrophages to reduce ROS levels lipid oxidation, thereby significantly inhibiting inflammation-related processes. Notably, while cell formation, also alleviates endothelial cells senescence. After intravenous administration, effectively inhibits atherosclerosis in mice through synergistic effects antisenescence antioxidant properties, reducing plaque area by approximately 5-fold. This study provides an effective strategy atherosclerosis.

Language: Английский

Citations

0