Introduction to the Special Issue of Cytoskeleton on the molecular and cell biology of septins DOI
Serge Mostowy, Aurélie Bertin, Helge Ewers

et al.

Cytoskeleton, Journal Year: 2023, Volume and Issue: 80(7-8), P. 139 - 140

Published: June 6, 2023

Language: Английский

Chemical Proteomics Reveals Nε-Fatty-Acylation of Septins by Rho Inactivation Domain (RID) of the Vibrio MARTX Toxin to Alter Septin Localization and Organization DOI Creative Commons
Yaxin Xu, Ke Ding, Tao Peng

et al.

Molecular & Cellular Proteomics, Journal Year: 2024, Volume and Issue: 23(3), P. 100730 - 100730

Published: Feb. 2, 2024

Vibrio species, the Gram-negative bacterial pathogens causing cholera and sepsis, produce multiple secreted virulence factors for infection pathogenesis. Among these is multifunctional-autoprocessing repeats-in-toxin (MARTX) toxin that releases several critical effector domains with distinct functions inside eukaryotic host cells. One such domain, Rho inactivation domain (RID), has been discovered to catalyze long-chain N

Language: Английский

Citations

6
The Roles of Septins in Regulating Fission Yeast Cytokinesis DOI Creative Commons

Shengnan Zheng,

Biyu Zheng,

Chuanhai Fu

et al.

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(2), P. 115 - 115

Published: Jan. 30, 2024

Cytokinesis is required to separate two daughter cells at the end of mitosis, and septins play crucial roles in many aspects cytokinesis. While have been intensively studied model organisms, including budding yeast Saccharomyces cerevisiae, relatively less characterized fission Schizosaccharomyces pombe, which has proven be an excellent organism for studying fundamental cell biology. In this review, we summarize findings made yeasts mainly from four aspects: domain structure septins, localization during cycle, regulating cytokinesis, regulatory proteins septins.

Language: Английский

Citations

4
Septin dynamics and organization in mammalian cells DOI Creative Commons

Janik N. Schampera,

Carsten Schwan

Current Opinion in Cell Biology, Journal Year: 2024, Volume and Issue: 91, P. 102442 - 102442

Published: Nov. 6, 2024

Language: Английский

Citations

3
Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis DOI
Davinder Singh, Yajun Liu, Yihua Zhu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 12, 2024

Septins can function as scaffolds for protein recruitment, membrane-bound diffusion barriers, or membrane curvature sensors. are important cytokinesis, but their exact roles still obscure. In fission yeast, four septins (Spn1 to Spn4) accumulate at the rim of division plane rings. The octameric exocyst complex, which tethers exocytic vesicles plasma membrane, exhibits a similar localization and is essential deposition during cytokinesis. Without septins, spreads across absent from septum formation. These results suggest that physically interact proper localization. Indeed, we predicted six pairs direct interactions between septin subunits by AlphaFold2 ColabFold, most them confirmed co-immunoprecipitation yeast two-hybrid assays. Exocyst mislocalization in mistargeting secretory cargos, leads cell-separation delay mutants. Our indicate guide targeting complex on vesicle tethering cytokinesis through physical interactions.

Language: Английский

Citations

1
Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis DOI Open Access
Davinder Singh, Yajun Liu, Yihua Zhu

et al.

Published: Sept. 4, 2024

Septins can function as scaffolds for protein recruitment, membrane-bound diffusion barriers, or membrane curvature sensors. are important cytokinesis, but their exact roles still obscure. In fission yeast, four septins (Spn1 to Spn4) accumulate at the rim of division plane rings. The octameric exocyst complex, which tethers exocytic vesicles plasma membrane, exhibits a similar localization and is essential deposition during cytokinesis. Without septins, spreads across absent from septum formation. These results suggest that physically interact proper localization. Indeed, we predicted six pairs direct interactions between septin subunits by AlphaFold2 ColabFold, most them confirmed co-immunoprecipitation yeast two-hybrid assays. Exocyst mislocalization in mistargeting secretory cargos, leads cell-separation delay mutants. Our indicate guide targeting complex on vesicle tethering cytokinesis through physical interactions.

Language: Английский

Citations

0
Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis DOI Open Access
Davinder Singh, Yajun Liu, Yihua Zhu

et al.

Published: Sept. 4, 2024

Septins can function as scaffolds for protein recruitment, membrane-bound diffusion barriers, or membrane curvature sensors. are important cytokinesis, but their exact roles still obscure. In fission yeast, four septins (Spn1 to Spn4) accumulate at the rim of division plane rings. The octameric exocyst complex, which tethers exocytic vesicles plasma membrane, exhibits a similar localization and is essential deposition during cytokinesis. Without septins, spreads across absent from septum formation. These results suggest that physically interact proper localization. Indeed, we predicted six pairs direct interactions between septin subunits by AlphaFold2 ColabFold, most them confirmed co-immunoprecipitation yeast two-hybrid assays. Exocyst mislocalization in mistargeting secretory cargos, leads cell-separation delay mutants. Our indicate guide targeting complex on vesicle tethering cytokinesis through physical interactions.

Language: Английский

Citations

0
Introduction to the Special Issue of Cytoskeleton on the molecular and cell biology of septins DOI
Serge Mostowy, Aurélie Bertin, Helge Ewers

et al.

Cytoskeleton, Journal Year: 2023, Volume and Issue: 80(7-8), P. 139 - 140

Published: June 6, 2023

Language: Английский

Citations

0