Harnessing the Power of Artificial Intelligence in Pharmaceuticals: Current Trends and Future Prospects

Intelligent Pharmacy, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Economic income and survival in patients affected by glioblastoma: A systematic review and meta-analysis

Neuro-Oncology Practice, Journal Year: 2024, Volume and Issue: 11(5), P. 546 - 555

Published: May 11, 2024

Within socioeconomic variables, economic income has been associated with the prognosis of patients glioblastoma. However, studies investigating this issue provided conflicting results.

Language: Английский

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The Association of Neighborhood-Level Deprivation with Glioblastoma Outcomes: A Single Center Cohort Study

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Purpose Glioblastoma is the most common primary brain malignancy. Though literature has suggested association of glioblastoma outcomes and socioeconomic status, there limited evidence regarding neighborhood-level deprivation on outcomes. The aim this study was to assess impact survival. Methods We retrospectively reviewed all adult patients seen at a single institution from 2008 2023. Neighborhood assessed via Area Deprivation Index (ADI), with higher ADI indicating greater neighborhood deprivation. Log-rank tests multivariate cox regression used effect other variables while controlling for a priori selected clinical known relevance Results In total, 1464 met inclusion criteria. average age diagnosis 60 ± 14 years median overall survival 13.8 months (IQR 13-14.8). cohort 66(IQR 46-84). Patients high had worse compared low (11.7 vs 14.8 months, p=.001). multivariable model, (HR 1.25, 95%CI 1.09-1.43). To account changes in WHO guidelines, we implemented model diagnosed between 2017-2023 findings were consistent 1.26,95%CI 1.01-1.56). Conclusion report first demonstrating have after biomolecular markers. status may be prognostic marker

Language: Английский

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The association of neighborhood-level deprivation with glioblastoma outcomes: a single center cohort study

Journal of Neuro-Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Glioblastoma is the most common primary brain malignancy. Though literature has suggested association of glioblastoma outcomes and socioeconomic status, there limited evidence regarding neighborhood-level deprivation on outcomes. The aim this study was to assess impact survival. We retrospectively reviewed all adult patients seen at a single institution from 2008 2023. Neighborhood assessed via Area Deprivation Index (ADI), with higher ADI indicating greater neighborhood disadvantage. Log-rank tests multivariate cox regression used effect other variables while controlling for priori selected clinical known relevance In total, 1464 met inclusion criteria. average age diagnosis 60 ± 14 years median overall survival 13.8 months (IQR 13-14.8). cohort 66(IQR 46-84). Patients high disadvantage had worse compared those without (11.7 vs. 14.8 months, p =.001). multivariable model, (HR 1.25, 95%CI 1.09-1.43). To account changes in WHO guidelines, we implemented model diagnosed between 2017 2023 findings were consistent 1.26,95%CI 1.01-1.56). report first demonstrating have after biomolecular markers. status may be prognostic marker

Language: Английский

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Sex-Specific Differences in Patients withIDH1–Wild-Type Grade 4 Glioma in the ReSPOND Consortium

American Journal of Neuroradiology, Journal Year: 2024, Volume and Issue: 45(9), P. 1299 - 1307

Published: April 29, 2024

Understanding sex-based differences in patients with glioblastoma is necessary for accurate personalized treatment planning to improve patient outcomes. Our purpose was investigate sex-specific molecular, clinical, and radiologic tumor parameters, as well survival outcomes glioblastoma, isocitrate dehydrogenase-1 wild-type (IDH1-WT), grade 4. Retrospective data of 1832 IDH1-WT comprehensive information on parameters acquired from the Radiomics Signatures Precision Oncology Glioblastoma consortium. Data imputation performed missing values. Sex-based such age, molecular preoperative Karnofsky performance score (KPS), volumes, epicenter, laterality were assessed through nonparametric tests. Spatial atlases generated by using MRI maps visualize characteristics. Survival time analysis log-rank tests Cox proportional hazard analyses. diagnosed at a median age 64 years women compared 61.9 men (false discovery rate [FDR] = 0.003). Men had higher KPS (above 80) (60.4% versus 69.7% men, FDR 0.044). Women lower volumes enhancing (16.7 cm3 20.6 0.001), necrotic core (6.18 7.76 edema regions (46.9 59.2 0.0001). The right temporal region most common epicenter overall population. Right left lobes more frequently involved men. There no mortality ratios. Higher unmethylated O6-methylguanine-DNA-methyltransferase promoter undergoing subtotal resection increased risk both women. study demonstrates significant clinical glioblastoma. Sex not an independent prognostic factor influencing are identical

Language: Английский

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Disparities in Neuro-Oncology

Current Neurology and Neuroscience Reports, Journal Year: 2023, Volume and Issue: 23(12), P. 815 - 825

Published: Oct. 27, 2023

Language: Английский

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County-level disparities in care for patients with glioblastoma

Neurosurgical FOCUS, Journal Year: 2023, Volume and Issue: 55(5), P. E12 - E12

Published: Nov. 1, 2023

OBJECTIVE Racial and socioeconomic disparities in neuro-oncological care for patients with brain tumors remain underexplored. This study aimed to analyze county-level glioblastoma (GBM) the United States, focusing on access surgery use of adjuvant temozolomide chemotherapy radiation therapy. METHODS Using repeated cross-sectional data from Surveillance, Epidemiology, End Results 17 database; Area Health Resources File; American Community Survey, 2010 2019, authors performed multivariate regression analyses understand associations between racial characteristics, as well rates performed, delays surgery, therapy newly diagnosed GBM. RESULTS In total, 29,609 GBM 602 different US counties over a decade were included this study. Counties lower associated higher percentage Black residents (coefficient [CE] −0.001, 95% CI −0.002 0; p < 0.05) being located Midwest (CE −0.132, −0.195 −0.069; 0.001) or West −0.127, −0.189 −0.065; relative Northeast. delayed surgical treatment more likely lack neurosurgeons (adjusted OR [aOR] 2.52, 1.77–3.60; 0.001), have (aOR 1.011, 1.00–1.02; 0.05), be 3.042, 1.12–8.24; 3.175, 1.12–8.97 0.05). high less percentages 0.987, 0.980–0.995; 0.01) uninsured individuals 0.962, 0.937–0.987; 0.01). CONCLUSIONS without those demonstrate overall underscores need targeted interventions policies that address structural barriers healthcare access, improve equitable distribution neurosurgery workforce, ensure timely comprehensive all populations.

Language: Английский

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Patients with glioblastoma: A tale of health care access and genetic ancestry

Cancer, Journal Year: 2024, Volume and Issue: 130(22), P. 3797 - 3799

Published: July 8, 2024

The incidence of glioblastoma, previously described as a disease predominantly affecting non‐Hispanic White patients, was higher among non‐White patients in the authors' recent study which racial/ethnical composition representative overall population. These findings offer an opportunity to accurately redefine patient population with glioblastoma bearing burden this United States.

Language: Английский

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Ethnicity in neuro-oncology research: How are we doing and how can we do better?

Journal of Neuro-Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Language: Английский

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Neighborhood disadvantage is associated with treatment access outcomes and survival among individuals with a primary brain tumor

Neuro-Oncology Practice, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Neighborhood disadvantage is linked to lower rates of healthcare access. To understand how residence affects the primary brain tumor (PBT) population, we assessed neighborhood and population density with treatment access outcomes among a cohort 666 adult participants PBT study entry data in large observational at National Institutes Health (NIH) (NCT#: NCT02851706). We (measured by area deprivation index [ADI]) symptom duration before diagnosis time using ordinal logistic linear regression. Kaplan-Meier survival curves were estimated ADI, overall stratified residential distance NIH, grade, age. Among participants, 24% lived more disadvantaged areas. sample, there no associations between ADI or duration, but any was longer for patients living neighborhoods (β = 7.78; 95% confidence interval [CI] 0.02, 15.55), especially those low-grade PBTs 36.19; 95%CI 12.17, 60.20). Time nonurbanized areas further from NIH 0.63; CI 0.08, 1.17). Patients had higher 5-year compared less (P .02). Individuals treatment. Future efforts should focus on strategies reach neighborhoods.

Language: Английский

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