Reviewer #1 (Public Review): Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit DOI Open Access
Kei Jokura,

Nobuo Ueda,

Martin Gühmann

et al.

Published: Sept. 19, 2023

Nitric oxide (NO) produced by nitric-oxide synthase (NOS) is a key regulator of animal physiology. Here we uncover function for NO in the integration UV exposure and gating UV-avoidance circuit. We studied UV/violet avoidance mediated brain ciliary photoreceptors (cPRCs) larvae annelid Platynereis dumerilii. In larva, NOS expressed interneurons (INNOS) postsynaptic to cPRCs. stimulation cPRCs triggers INNOS activation production. signals retrogradely induce their sustained post-stimulus through an unconventional guanylate cyclase. This late inhibits serotonergic ciliomotor neurons downward swimming. mutants, retrograde signalling, circuit output are defective. By mathematical modelling, recapitulate phototransduction dynamics wild-type mutant larvae. Our results reveal how NO-mediated signalling gates synaptic induces short-term memory orchestrate light-avoidance behaviour.

Language: Английский

Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates DOI Open Access
Annamaria Locascio, Giovanni Annona,

Filomena Caccavale

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 11182 - 11182

Published: July 6, 2023

Nitric oxide (NO) is a key signaling molecule in almost all organisms and active variety of physiological pathological processes. Our understanding the peculiarities functions this simple gas has increased considerably by extending studies to non-mammal vertebrates invertebrates. In review, we report nitric synthase (Nos) genes so far characterized chordates provide an extensive, detailed, comparative analysis function NO aquatic tunicates, cephalochordates, teleost fishes, amphibians. This comprehensive set data adds new elements our Nos evolution, from single gene commonly found invertebrates three present vertebrates.

Language: Английский

Citations

8
Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit DOI Creative Commons
Kei Jokura,

Nobuo Ueda,

Martin Gühmann

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 4, 2023

Abstract Nitric oxide (NO) produced by nitric-oxide synthase (NOS) is a key regulator of animal physiology. Here we uncover function for NO in the integration UV exposure and gating UV-avoidance circuit. We studied UV/violet avoidance mediated brain ciliary photoreceptors (cPRCs) larvae annelid Platynereis dumerilii . In larva, NOS expressed interneurons (INNOS) postsynaptic to cPRCs. stimulation cPRCs triggers INNOS activation production. signals retrogradely induce their sustained post-stimulus through an unconventional guanylate cyclase. This late inhibits serotonergic ciliomotor neurons downward swimming. mutants, retrograde signalling, circuit output are defective. By mathematical modelling, recapitulate phototransduction dynamics wild-type mutant larvae. Our results reveal how NO-mediated signalling gates synaptic induces short-term memory orchestrate light-avoidance behaviour.

Language: Английский

Citations

4
Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit DOI Open Access
Kei Jokura,

Nobuo Ueda,

Martin Gühmann

et al.

Published: Sept. 19, 2023

Nitric oxide (NO) produced by nitric-oxide synthase (NOS) is a key regulator of animal physiology. Here we uncover function for NO in the integration UV exposure and gating UV-avoidance circuit. We studied UV/violet avoidance mediated brain ciliary photoreceptors (cPRCs) larvae annelid Platynereis dumerilii . In larva, NOS expressed interneurons (INNOS) postsynaptic to cPRCs. stimulation cPRCs triggers INNOS activation production. signals retrogradely induce their sustained post-stimulus through an unconventional guanylate cyclase. This late inhibits serotonergic ciliomotor neurons downward swimming. mutants, retrograde signalling, circuit output are defective. By mathematical modelling, recapitulate phototransduction dynamics wild-type mutant larvae. Our results reveal how NO-mediated signalling gates synaptic induces short-term memory orchestrate light-avoidance behaviour.

Language: Английский

Citations

4
Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit DOI Open Access
Kei Jokura,

Nobuo Ueda,

Martin Gühmann

et al.

Published: Sept. 19, 2023

Nitric oxide (NO) produced by nitric-oxide synthase (NOS) is a key regulator of animal physiology. Here we uncover function for NO in the integration UV exposure and gating UV-avoidance circuit. We studied UV/violet avoidance mediated brain ciliary photoreceptors (cPRCs) larvae annelid Platynereis dumerilii . In larva, NOS expressed interneurons (INNOS) postsynaptic to cPRCs. stimulation cPRCs triggers INNOS activation production. signals retrogradely induce their sustained post-stimulus through an unconventional guanylate cyclase. This late inhibits serotonergic ciliomotor neurons downward swimming. mutants, retrograde signalling, circuit output are defective. By mathematical modelling, recapitulate phototransduction dynamics wild-type mutant larvae. Our results reveal how NO-mediated signalling gates synaptic induces short-term memory orchestrate light-avoidance behaviour.

Language: Английский

Citations

1
Reviewer #1 (Public Review): Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit DOI Open Access
Kei Jokura,

Nobuo Ueda,

Martin Gühmann

et al.

Published: Sept. 19, 2023

Nitric oxide (NO) produced by nitric-oxide synthase (NOS) is a key regulator of animal physiology. Here we uncover function for NO in the integration UV exposure and gating UV-avoidance circuit. We studied UV/violet avoidance mediated brain ciliary photoreceptors (cPRCs) larvae annelid Platynereis dumerilii. In larva, NOS expressed interneurons (INNOS) postsynaptic to cPRCs. stimulation cPRCs triggers INNOS activation production. signals retrogradely induce their sustained post-stimulus through an unconventional guanylate cyclase. This late inhibits serotonergic ciliomotor neurons downward swimming. mutants, retrograde signalling, circuit output are defective. By mathematical modelling, recapitulate phototransduction dynamics wild-type mutant larvae. Our results reveal how NO-mediated signalling gates synaptic induces short-term memory orchestrate light-avoidance behaviour.

Language: Английский

Citations

0