British Journal of Pharmacy,
Journal Year:
2022,
Volume and Issue:
7(2)
Published: July 4, 2022
We
developed
a
set
of
methoxypoly(ethyleneglycol)-co-poly(N3-ε-caprolactone)
(mPEG-N3PCL)copolymers
with
different
types
amine
linkers
and
investigated
thecontribution
the
introduced
amino
linker
to
gene
delivery
efficiency
ofnanoparticles.
The
nanoparticles
were
crosslinked
from
caprolactone
regionswith
redox-responsive
linker.
Formulation
variables
including
Redox-crosslinkingand
N:P
ratio
examined
obtain
optimal
size
andhighest
siRNA
entrapment
efficacy
(EE).
characterized
byDLS,
nanodrop
UV-vis
spectroscopy.
Nanoparticle
size,
polydispersity
index
siRNAentrapment
found
depend
on
all
formulationvariables
specially
ratio.
formulation
5
with56.13
nm
in
92.24%
EE
was
chosen
as
formulation.Controllable
loading
releasepattern
by
redox-responsivity
make
this
class
novel
carriers
promisingcandidate
for
tumour
targeted
applications.
Journal of Composites Science,
Journal Year:
2023,
Volume and Issue:
7(2), P. 54 - 54
Published: Feb. 3, 2023
Extracting
the
mechanical
properties
of
a
composite
hydrogel;
e.g.,
bioglass
(BG)–collagen
(COL),
is
often
difficult
due
to
complexity
experimental
procedure.
BGs
could
be
embedded
in
COL
and
thereby
improve
for
bone
tissue
engineering
applications.
This
paper
proposed
deep-learning-based
approach
extract
hydrogel
directly
from
microstructural
images.
Four
datasets
various
shapes
(9000
2D
images)
generated
by
finite
element
analysis
showed
that
deep
neural
network
(DNN)
model
efficiently
predict
hydrogel,
including
Young’s
modulus
Poisson’s
ratio.
ResNet
AlexNet
architecture
were
tuned
ensure
excellent
performance
high
accuracy
methods
with
R-values
greater
than
0.99
mean
absolute
error
prediction
less
7%.
The
results
full
dataset
revealed
had
better
predicting
elastic
material
BGs-COL
0.97
compared
0.96
ratio,
respectively.
work
provided
bridging
combine
DNN
applications
diverse
fields
such
as
engineering,
materials
science,
medical
engineering.
Journal of Soft Computing and Decision Analytics,
Journal Year:
2023,
Volume and Issue:
1(1), P. 181 - 208
Published: Sept. 11, 2023
Encountering
numerous
vehicles
on
the
roads
can
pose
several
risks,
including
a
higher
probability
of
accidents.
To
address
these
issues,
thorough
examination
cars
significantly
reduce
dangers.
Technical
inspection
centers
play
crucial
role
in
this
process
and
should
be
easily
accessible.
provide
most
customer
service
coverage
at
lowest
cost
transportation
for
technical
centers,
facility
location
optimization
is
proposed
paper.
Specifically,
we
investigate
(TICs)
as
maximum
problem
while
minimizing
TIC
locations'
construction
customers'
transportation.
deal
with
problem,
propose
robust
programming
considering
our
numeric
data's
uncertainty.
Our
research
contributes
to
by
providing
novel
insight
into
solving
using
hybrid
mathematical
model.
It
presents
two-objective
linear
model
binary
variables
problem.
We
used
Augmented
Epsilon
Constraint
(AEC)
method
via
CPLEX
solver
Non-dominated
Sorting
Genetic
Algorithm
II
(NSGA-II)
large-scale
problems
solve
A
case
study
was
conducted
test
numerical
analysis
methodology
practical
varying
scales.
The
final
results
demonstrate
effectiveness
approach
meeting
optimality
feasibility
robustness
criteria.
Identifying
optimal
locations
regarding
paper's
main
objective
proves
advantage
mentioned
innovative
methodology.
International Journal for Numerical Methods in Biomedical Engineering,
Journal Year:
2025,
Volume and Issue:
41(3)
Published: March 1, 2025
ABSTRACT
Crestal
placement
of
short
plateau
implants
in
compromised
jaws
may
cause
implant
failure
due
to
bone
overstress.
The
aim
was
evaluate
the
impact
different
sized
on
adjacent
overload
and
load‐bearing
ability
terms
proposed
index—ultimate
functional
load
(UFL).
Three‐dimensional
models
osseointegrated
placed
types
III
IV
were
analysed
by
FEM
for
case
patient‐specific
variations
cortical
elasticity
modulus.
Maximum
von
Mises
stresses
surrounding
calculated
compared
with
cancellous
ultimate
strength
characteristics
determine
UFL
index
studied
implants.
magnitudes
influenced
their
dimensions,
elasticity,
quality.
predetermined
strength.
maxilla
moderate
modulus
allows
wide
screwless
molar
site
good
clinical
perspective.
Journal of Applied Biomaterials & Functional Materials,
Journal Year:
2025,
Volume and Issue:
23
Published: April 1, 2025
Bruxism
affects
millions
worldwide,
leading
to
dental
damage
like
worn
teeth
and
tooth
loss.
Resin
3D
printing
presents
a
promising
method
for
creating
intricate,
comfortable,
durable
occlusal
splints.
This
study
examines
how
parameters—layer
thickness,
orientation
angle,
curing
time—affect
the
mechanical
(compressive
strength,
wear
rate,
impact
strength)
physical
(water
sorption,
surface
roughness,
dimensional
accuracy)
properties
of
splints
made
from
methacrylate-based
resin.
A
total
120
specimens
were
produced
according
American
Society
Testing
Materials
(ASTM)
standards
using
different
parametric
combinations.
The
response
methodology
(RSM)
was
applied
optimize
key
parameters.
optimum
parameters
compressive
strength
include
layer
height
16.5
mm,
time
93.6
min,
an
angle
12.8º,
yielding
9.05
MPa,
rate
159
mm
3
/min,
71.58
J/m.
Similarly,
results
minimum
roughness
(8.013
microns),
maximum
accuracy
(97.67
water
sorption
(0.386%)
are
achieved
at
thickness
16
93
12º.
Results
show
that
optimizing
resin
significantly
reduces
production
costs,
particularly
in
regions
with
limited
access
care,
while
promoting
sustainable
solutions
by
minimizing
environmental
traditional
manufacturing
methods
enhancing
efficiency
splint
production.
Journal of Materials Research and Technology,
Journal Year:
2023,
Volume and Issue:
27, P. 3815 - 3824
Published: Nov. 1, 2023
This
paper
investigates
the
fabrication
and
characterization
of
piezoelectric
properties
in
electrospun
polylactic
acid
(PLA)
scaffolds
for
tissue
engineering
applications.
The
aim
is
to
enhance
mechanical
electrical
mimic
native
tissues.
Thermo-mechanical
processing
techniques,
including
post-processing
under
various
temperature,
weight,
time
conditions,
are
employed
modify
scaffolds.
effects
these
parameters
on
morphological,
piezoelectric,
crystalline
PLA
examined.
exhibit
partially
parallel
beadles
fibers
with
varying
degrees
alignment
thickness,
depending
applied
parameters.
These
morphological
features
play
a
crucial
role
enhancing
Differential
scanning
calorimetry
(DSC)
X-ray
diffraction
(XRD)
analyses
demonstrate
that
thermo-mechanical
promotes
formation
α
phase
increases
degree
crystallinity
orientation
influenced
by
time,
temperature
during
post-processing.
Furthermore,
study
examines
conductivity
ferroelectric
results
indicate
enhanced
scaffolds,
as
evidenced
measured
output
voltages.
However,
behavior
not
observed
due
absence
crystal
symmetry
PLA.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: April 10, 2024
Statistical
Shape
Models
(SSMs)
are
widely
used
in
orthopedics
to
extract
the
main
shape
features
from
bone
regions
(e.g.,
femur).
This
study
aims
develop
an
SSM
of
femoral
medullary
canal,
investigate
its
anatomical
variability,
and
assess
variations
depending
on
canal
length.
The
canals
were
isolated
72
CT
femur
scans,
through
a
threshold-based
segmentation.
A
region
interest
(ROI)
was
selected;
sixteen
segments
extracted
ROI,
ranging
25%
full
length
down
most
distal
segment.
An
developed
identify
modes
variation
for
each
number
Principal
Components
(PCs)
needed
explain
at
least
90%
variance
three/four
based
examined
relationship
between
identified
PCs
geometric
parameters
like
length,
radius
curvature,
ellipticity,
mean
diameter,
conicity,
reporting
range
percentage
these
SSMs
provide
insights
into
variability
emphasizing
importance
considering
different
capture
various
These
findings
can
contribute
design
personalized
orthopedic
implants
involving
femur.
Progress in Biomedical Engineering,
Journal Year:
2024,
Volume and Issue:
7(1), P. 012003 - 012003
Published: Oct. 16, 2024
Abstract
The
design
and
optimization
of
bone
scaffolds
are
critical
for
the
success
tissue
engineering
(BTE)
applications.
This
review
paper
provides
a
comprehensive
analysis
computational
methods
scaffold
architecture,
focusing
on
balance
between
mechanical
stability,
biological
compatibility,
manufacturability.
Finite
element
method
(FEM),
fluid
dynamics
(CFD),
various
algorithms
discussed
their
roles
in
simulating
refining
designs.
integration
multiobjective
topology
has
been
highlighted
developing
that
meet
multifaceted
requirements
BTE.
Challenges
such
as
need
consideration
manufacturing
constraints
incorporation
degradation
regeneration
models
into
process
have
identified.
underscores
potential
advanced
tools
additive
techniques
evolving
field
BTE,
aiming
to
improve
patient
outcomes
regeneration.
reliability
current
is
examined,
with
suggestions
incorporating
non-deterministic
approaches
vivo
validations
enhance
practical
application
optimized
scaffolds.
concludes
call
further
research
artificial
intelligence-based
advance
optimization.