Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e31596 - e31596
Published: May 1, 2024
According to estimates, there were 570,000 new cases of cervical cancer in 2018, making it the fourth most common malignancy among women worldwide. Almost all 342,000 deaths from take place low- and middle-income countries, accounting for 90 % deaths. Few studies use structural equation modeling comprehensively analyze predictors screening.
Language: Английский
Published: Jan. 10, 2024
Cervical cancer, primarily caused by high-risk human papillomavirus (HR-HPV) types 16 and 18, is a major global health concern. Persistent HR-HPV infection can progress from reversible pre-cancerous lesions to invasive cervical which driven the oncogenic activity of (HPV) genes, particularly E6 E7. Traditional screening methods, including cytology HPV testing, have limited sensitivity specificity. This review explores ap-plication p16/Ki-67 dual-staining for cancer screening. advanced im-munocytochemical method allows simultaneously detecting p16 Ki-67 proteins within epithelial cells, offering more specific approach triaging HPV-positive women. Dual staining traditional methods are compared, demonstrating their high negative predictive value but low The increased dual results in higher detection rates CIN2+ lesions, crucial preventing progression. However, its specificity may lead false-positive unnecessary biopsies. implications integrating into contemporary strategies, considering evolving landscape vaccination changes genotype prevalence also discussed. New guidelines further research necessary elucidate long-term effects protocols.
Language: Английский
Citations
2
Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2024, Volume and Issue: 3(5), P. 59 - 79
Published: Oct. 22, 2024
Cancer of the cervix is a disease that ubiquitous and frequently severe, it affects women all over world. Conventional treatment methods, which include surgical procedures, chemotherapy, radiation therapy, have been shown to dramatically enhance survival rates; nevertheless, these methods are accompanied with adverse effects difficulties might an influence on quality life patient. In recent years, there has growing interest in utilisation essential oils cancer management cervical cancer. This review offers comprehensive investigation into function various play development It also includes insights possible advantages as well body research conducted them. Additionally, analysis dives future directions issues will be faced this developing industry, particular focus advancements delivery interesting areas. For purpose enhancing anticancer qualities oils, encapsulation solid lipid nanoparticles, nanoemulsification or combining conventional treatments demonstrated promising results. attempts provide viewpoint, balancing potential natural therapies obstacles need addressed. As employment continues develop, study attempt perspective. The strike balance between
Language: Английский
Citations
2
BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)
Published: Jan. 13, 2024
Abstract Background Human papillomavirus (HPV) is one of the most prevalent sexually transmitted diseases worldwide. The present review was conducted to accumulate evidence on relationship between cervicovaginal human infection and serum vitamin D status. Methods Electronic databases including Web Science, Embase, Scopus, PubMed were searched by different combinations keywords related “human papillomavirus” “vitamin D”, obtained from Mesh Emtree with AND, OR operators without any time restriction until December 24, 2022. Selection articles based inclusion exclusion criteria. Newcastle-Ottawa Scale used for quality assessment. Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) checklist applied reporting. Results In total, 276 citations retrieved. After removing duplicates, non-related articles, full texts 7 reviewed 11168 participants. Three studies reported that there a positive deficiency while three did not. One study showed significant association higher stores short-term high-risk persistence. Conclusions findings no firm level infection, although possible could not be discarded. Further investigations are needed reach sound evidence.
Language: Английский
Citations
1
PLOS Global Public Health, Journal Year: 2024, Volume and Issue: 4(1), P. e0002848 - e0002848
Published: Jan. 19, 2024
High-income countries have documented a significant decline in the incidence and mortality of cervical cancer over past decade but such data from low middle-income as Uganda is limited to ascertain trends. There also paucity on burden comparison other gynaecologic malignancies there likelihood that might be rise. To describe current trends magnitude gynaecological histological types, we conducted retrospective records review charts patients admitted with ward Mbarara Regional Referral Hospital (MRRH) between January 2017 December 2022. Of 875 MRRH 6-year period, 721 (82.4%) had cancer. Patients were significantly older than those malignancies: (50.2±11.5 versus 43.8± 15.0 respectively, p<0.001). Between 2022, rates increased by 17% annually compared cancers (OR:1.17; 95% CI 1.06–1.28, p = 0.0046), majority (92.7%, n 668) having squamous cell carcinoma. Most (87.9%, 634) late-stage disease (stage 2 above) referred Cancer Institute for chemoradiation. These results imply need scale up screening services preventive measures vaccination against human papilloma virus.
Language: Английский
Citations
1
Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e31596 - e31596
Published: May 1, 2024
According to estimates, there were 570,000 new cases of cervical cancer in 2018, making it the fourth most common malignancy among women worldwide. Almost all 342,000 deaths from take place low- and middle-income countries, accounting for 90 % deaths. Few studies use structural equation modeling comprehensively analyze predictors screening.
Language: Английский
Citations
1