Mendelian randomization combined with multi-omics explores the relationship between heart failure and cancer DOI Creative Commons
Tian Sun,

Na Mei,

Yanting Su

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(10), P. 2928 - 2939

Published: Jan. 1, 2024

Background: Whether there is an association between HF (HF) and cancer has not been conclusively established, it clear whether patients with can share similar hospitalization strategies outcomes HF.Methods: Genome-wide summary statistics were performed using a two-sample Mendelian randomization (MR) method for from the GWAS directory, co-localization Summary Data-Based Randomization (SMR) analyses to identify HF-associated genes, transcriptomic analyze roles of these genes in clinical diagnosis targeted therapies multiple types.Results: Two-sample MR analysis showed that increased risk was associated decreased cervical, brain, breast, colorectal, lung, skin cancers, combined SMR identified ABO SURF1 as factor protective against cancer, whereas cancer.Conclusion: There no causal relationship heart failure cancers (Cervical, lung cancers) factors, however trend toward negative occurrence.

Language: Английский

The Gut Microbiota: A Key Player in Cadmium Toxicity - Implications for Disease, Interventions, and Combined Toxicant Exposures DOI

Zahra Shamsipour Nehzomi,

Kobra Shirani

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 88, P. 127570 - 127570

Published: Nov. 23, 2024

Language: Английский

Citations

3
Mendelian randomization combined with multi-omics explores the relationship between heart failure and cancer DOI Creative Commons
Tian Sun,

Na Mei,

Yanting Su

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(10), P. 2928 - 2939

Published: Jan. 1, 2024

Background: Whether there is an association between HF (HF) and cancer has not been conclusively established, it clear whether patients with can share similar hospitalization strategies outcomes HF.Methods: Genome-wide summary statistics were performed using a two-sample Mendelian randomization (MR) method for from the GWAS directory, co-localization Summary Data-Based Randomization (SMR) analyses to identify HF-associated genes, transcriptomic analyze roles of these genes in clinical diagnosis targeted therapies multiple types.Results: Two-sample MR analysis showed that increased risk was associated decreased cervical, brain, breast, colorectal, lung, skin cancers, combined SMR identified ABO SURF1 as factor protective against cancer, whereas cancer.Conclusion: There no causal relationship heart failure cancers (Cervical, lung cancers) factors, however trend toward negative occurrence.

Language: Английский

Citations

1