Composite Nanocoatings of Biomedical Magnesium Alloy Implants: Advantages, Mechanisms, and Design Strategies

Advanced Science, Journal Year: 2023, Volume and Issue: 10(18)

Published: April 25, 2023

The rapid degradation of magnesium (Mg) alloy implants erodes mechanical performance and interfacial bioactivity, thereby limiting their clinical utility. Surface modification is among the solutions to improve corrosion resistance bioefficacy Mg alloys. Novel composite coatings that incorporate nanostructures create new opportunities for expanded use. Particle size dominance impermeability may increase prolong implant service time. Nanoparticles with specific biological effects be released into peri-implant microenvironment during promote healing. Composite nanocoatings provide nanoscale surfaces cell adhesion proliferation. activate cellular signaling pathways, while those porous or core-shell structures carry antibacterial immunomodulatory drugs. vascular reendothelialization osteogenesis, attenuate inflammation, inhibit bacterial growth, thus increasing applicability in complex microenvironments such as atherosclerosis open fractures. This review combines physicochemical properties efficiency Mg-based biomedical summarize advantages nanocoatings, analyzes mechanisms action, proposes design construction strategies, purpose providing a reference promoting application further nanocoatings.

Language: Английский

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Targeted Drug Delivery Systems for Curcumin in Breast Cancer Therapy

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4275 - 4311

Published: July 1, 2023

Abstract: Breast cancer (BC) is the most prevalent type of in world and main reason women die from cancer. Due to significant side effects conventional treatments such as chemotherapy radiotherapy, search for supplemental alternative natural drugs with lower toxicity interest researchers. Curcumin (CUR) a polyphenol extracted turmeric. Numerous studies have demonstrated that CUR an effective anticancer drug works by modifying different intracellular signaling pathways. CUR's therapeutic utility severely constrained its short half-life vivo, low water solubility, poor stability, quick metabolism, oral bioavailability, potential gastrointestinal discomfort high doses. One practical solutions aforementioned issues development targeted delivery systems (TDDSs) based on nanomaterials. To improve targeting efficacy serve reference use TDDSs clinical setting, this review describes physicochemical properties bioavailability mechanism action BC, emphasis recent BC combination CUR, including passive TDDSs, active TDDSs. Keywords: breast cancer, curcumin, system, targeting,

Language: Английский

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Advances in lipid-based carriers for cancer therapeutics: Liposomes, exosomes and hybrid exosomes

Cancer Letters, Journal Year: 2023, Volume and Issue: 565, P. 216220 - 216220

Published: May 19, 2023

Language: Английский

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Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 879 - 879

Published: March 8, 2023

Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity breast is major challenge which coupled with patient-to-patient variations heterogeneity between cells within tumor. Revolutionary drug delivery expected provide solution that challenge. Chitosan nanoparticles (CSNPs) prospects as revolutionary system capable enhancing activity reducing negative impacts normal cells. use smart systems (SDDs) delivering materials improve bioactivity NPs understand intricacies has garnered significant interest. There are many reviews about CSNPs present various points view, but they not yet described series in therapy from cell uptake death. With this description, we will more complete picture for designing preparations SDDs. This review describes SDDSs, targeting stimulus response using their mechanism. Multimodal chitosan SDDs medication therapeutic results.

Language: Английский

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Glucose-Responsive Microparticle-Loaded Dissolving Microneedles for Selective Delivery of Metformin: A Proof-of-Concept Study

Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(2), P. 1269 - 1284

Published: Jan. 20, 2023

Diabetes mellitus (DM) is a metabolic disorder that one of the most common health problems in world, primarily type 2 DM (T2DM). Metformin (MTF), as first-line treatment DMT2, effective lowering glucose levels, but its oral administration causes problems, including gastrointestinal side effects, low bioavailability, and risk hypoglycemia. In this study, we formulated MTF into microparticles incorporating glucose-responsive polymer (MP–MTF–GR), which could potentially increase bioavailability extend control release according to levels. This system was delivered by dissolving microneedles (MP–MTF–GR–DMN), applied through skin, thereby preventing effects orally administered MTF. MP–MTF–GR using various concentrations gelatin combined with phenylboronic acid (PBA) material. encapsulated DMN polyvinyl pyrrolidone (PVP) alcohol (PVA) polymers. The physicochemical evaluation showed be completely entrapped MP percentage trapped increasing concentration without changing chemical structure producing stable MP. addition, results MP–MTF–GR–DMN had adequate mechanical strength properties penetration ability environmental changes. vitro ex vivo permeation study on media from formula increased levels media. successfully skin at 11.30 ± 0.29, 23.31 1.64, 36.12 3.77, 53.09 3.01 μg PBS, PBS + 1%, 2%, 4%, respectively, 24 h, indicates behavior. developed also proven nontoxic based hemolysis tests. Importantly, rat model combination approach provide better reduction compared other routes, reducing blood level normal after 3 h maintaining for 8 h. Furthermore, did not change moisture rats. promising alternative delivery overcome effectiveness T2DM therapy.

Language: Английский

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