International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 7273 - 7305
Published: July 1, 2024
Abstract:
Dried
toad
skin
(TS)
and
venom
(TV)
are
the
dried
of
Bufo
bufo
gargarizans
Cantor
melanostictus
Schneider
,
which
remove
internal
organs
white
secretions
retroauricular
glands.
Since
2005,
cinobufacini
preparations
have
been
approved
by
State
Food
Drug
Administration
for
use
as
adjuvant
therapies
in
treatment
various
advanced
cancers.
Meanwhile,
bufalenolides
has
identified
main
component
TS/TV,
exhibiting
antitumor
activity,
inducing
apoptosis
cancer
cells
inhibiting
cell
proliferation
or
metastasis
through
a
variety
signaling
pathways.
However,
clinical
agents
frequently
face
limitations
such
inherent
toxicity
at
high
concentrations
insufficient
tumor
targeting.
Additionally,
development
utilization
these
active
ingredients
hindered
poor
water
solubility,
low
bioavailability,
rapid
clearance
from
bloodstream.
To
address
challenges,
design
targeted
drug
delivery
system
(TDDS)
aims
to
enhance
improve
targeting
within
body,
increase
efficacy,
reduce
adverse
reactions.
This
article
reviews
TDDS
their
components,
including
passive,
active,
stimuli-responsive
TDDS,
provide
reference
advancing
use.
Keywords:
skin,
venom,
system,
passive
targeted,
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 114 - 114
Published: Jan. 15, 2025
Curcumin,
a
bioactive
compound
derived
from
the
rhizome
of
Curcuma
longa
L.,
has
garnered
significant
attention
for
its
potent
anticancer
properties.
Despite
promising
therapeutic
potential,
poor
bioavailability,
rapid
metabolism,
and
low
water
solubility
hinder
curcumin’s
clinical
application.
Nanotechnology
offers
viable
solution
to
these
challenges
by
enabling
development
curcumin-based
nanoparticles
(CNPs)
that
enhance
bioavailability
efficacy.
This
review
provides
comprehensive
overview
recent
advancements
in
design
synthesis
CNPs
cancer
therapy.
We
discuss
various
NP
formulations,
including
polymeric,
lipid-based,
inorganic
nanoparticles,
highlighting
their
role
improving
pharmacokinetic
pharmacodynamic
profiles.
The
mechanisms
which
exert
effects,
such
as
inducing
apoptosis,
inhibiting
cell
proliferation,
modulating
signaling
pathways,
are
explored
details.
Furthermore,
we
examine
preclinical
studies
have
demonstrated
efficacy
treating
different
types
tumors,
breast,
colorectal,
pancreatic
cancers.
Finally,
addresses
current
future
perspectives
translation
CNPs,
emphasizing
need
further
research
optimize
targeted
delivery
outcomes.
By
synthesizing
latest
research,
this
underscores
potential
avenue
advancing
Asian Journal of Pharmaceutical and Clinical Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 8 - 26
Published: Feb. 7, 2025
Hepatocellular
carcinoma
(HCC)
represents
a
significant
threat
to
global
health
and
is
responsible
for
mortality
rates
worldwide.
Conventional
treatment
options
such
as
surgery
chemotherapy
have
inherent
limitations.
In
order
remedy
these
deficits,
the
development
of
novel
therapeutic
strategies
essential.
Nanomedicines
shown
promise
in
HCC
they
offer
improved
stability,
controlled
release,
increased
drug
loading
capacity.
This
review
explores
application
nanoconstructs
treatment,
including
active
passive
targeting
strategies.
addition,
liver
cell
approaches,
moieties,
conjugation
chemistry
surface
functionalization
are
investigated.
A
compact
overview
various
approaches
also
given.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 8, 2024
Applying
artificial
intelligence
(AI)
to
nanomedicine
has
greatly
increased
the
production
of
specially
engineered
nanoscale
materials
for
tailored
medicine,
marking
a
significant
advancement
in
healthcare.
With
use
AI,
researchers
can
search
through
massive
databases
and
find
nano-properties
that
support
range
therapeutic
objectives,
eventually
producing
safer,
customized
nanomaterials.
AI
analyzes
patient
data,
including
clinical
genetic
information,
predict
results
individualized
care
makes
recommendations
therapy
improvement.
Furthermore,
logically
creates
nanocarriers
give
precise
controlled
drug
release
patterns
optimize
advantages
minimize
undesirable
side
effects.
Even
though
lot
potential
nanomedicine,
there
are
still
issues
data
integration
techniques,
moral
dilemmas,
requirement
governmental
backing.
Future
developments
tools
multidisciplinary
cooperation
between
scientists
with
expertise
biological
sciences
nanoengineering
essential
nanomedicine.
Together,
these
disciplines
propel
advancements
precision
contributing
ultimate
objective—a
future
which
combine
provide
really
The
authors
this
editorial
encourage
call
on
scientists,
physicians,
legislators
acknowledge
its
transform
treatment.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(7), P. 2131 - 2141
Published: Jan. 16, 2024
Ischemia/reperfusion
(IR)-induced
acute
lung
injury
(ALI)
has
a
high
mortality
rate.
Reactive
oxygen
species
(ROS)
play
crucial
role
in
causing
cellular
damage
and
death
IR-induced
ALI.
In
this
work,
we
developed
biomimetic
lung-targeting
nanoparticle
(PC@MB)
as
an
antioxidative
protector
for
treating
PC@MBs
showed
excellent
ROS
scavenging
Nrf2
activation
properties,
along
with
function
through
autologous
cell
membrane
coating.
The
exhibited
impressive
pulmonary
protective
via
redox
homeostasis
recovery
heme
oxygenase-1
activation.
could
maintain
viability
by
effectively
the
intracellular
restoring
equilibrium
lesion.
IR
mouse
model,
preferentially
accumulated
distinctly
repaired
pneumonic
damage.
Our
strategy
potential
to
offer
promising
therapeutic
paradigm
ALI
incorporation
of
different
mechanisms.
Journal of Inflammation Research,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 1735 - 1763
Published: March 1, 2024
Gouty
arthritis
(GA)
is
an
immune-mediated
disorder
characterized
by
severe
inflammation
due
to
the
deposition
of
monosodium
urate
(MSU)
crystals
in
joints.
The
pathophysiological
mechanisms
GA
are
not
yet
fully
understood,
and
therefore,
identification
effective
therapeutic
targets
paramount
importance.
Neutrophil
extracellular
traps
(NETs),
intricate
structure
DNA
scaffold,
encompassing
myeloperoxidase,
histones,
elastases
-
have
gained
significant
attention
as
a
prospective
target
for
gouty
arthritis,
their
innate
antimicrobial
immunomodulatory
properties.
Hence,
exploring
potential
NETs
remains
enticing
avenue
further
investigation.
During
process
formation
triggers
release
inflammatory
cytokines,
thereby
contributing
response,
while
MSU
cytokines
sequestered
degraded
aggregation
NETs.
Here,
we
provide
concise
summary
processes
underlying
initiation
resolution
mediated
Furthermore,
this
review
presents
overview
current
pharmacological
approaches
treating
summarizes
natural
synthetic
product-based
inhibitors
that
NET
novel
options,
alongside
elucidating
intrinsic
challenges
these
research.
Lastly,
limitations
HL-60
cell
suitable
substitute
neutrophils
research
summarized
discussed.
Series
recommendations
provided,
strategically
oriented
towards
guiding
future
investigations
effectively
address
concerns.
These
findings
will
contribute
enhanced
comprehension
interplay
between
GA,
facilitating
proposition
innovative
strategies
management
GA.
Drug Development and Industrial Pharmacy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 31
Published: March 21, 2025
This
review
examines
recent
advancements
in
nanoparticle-based
delivery
systems
for
phytochemicals,
focusing
on
their
role
overcoming
multidrug
resistance,
improving
therapeutic
efficacy,
and
facilitating
clinical
translation.
highlights
advances
nanoparticle-enabled
phytochemical
to
enhance
bioavailability,
improve
outcomes,
enable
targeted
applications.
By
comparing
various
nanoparticle
systems,
formulation
methods,
efficacy
data,
it
identifies
gaps
current
research
guides
the
development
of
more
effective,
next-generation
phytochemical-loaded
nanocarriers.
A
systematic
literature
published
between
2000
2024
was
conducted
using
PubMed,
Scopus,
Web
Science.
Articles
cancer
therapy
were
included.
Compounds
such
as
curcumin,
resveratrol,
quercetin,
epigallocatechin
gallate
demonstrate
enhanced
anti-cancer
when
encapsulated
nanoparticles,
leading
improved
increased
tumor
cell
targeting,
reduced
toxicity.
Clinical
trials
indicate
regression
fewer
adverse
effects.
Emerging
approaches-such
nanogels,
hybrid
combination
therapies
with
immune
checkpoint
inhibitors-further
refine
treatment
efficacy.
Nanoparticle-based
significantly
potential
making
them
promising
candidates
safer,
effective
treatments.
However,
challenges
related
regulatory
guidelines,
scalability,
long-term
safety
must
be
addressed
fully
realize
potential.
ABSTRACT
Breast
cancer
is
the
most
common
type
of
malignancy
among
women
worldwide.
Significant
achievements
have
been
made
in
diagnostic
tools
and
treatments
past
decade;
however,
complexity
heterogeneity
certain
breast
subtypes
often
lead
to
drug
resistance
metastatic
progression.
Owing
their
low
toxicity
high
variety,
natural
products
derivatives
are
becoming
increasingly
valuable
sources
for
small‐molecule
anticancer
drugs.
Polyphenols
more
widely
known
role
prevention
as
adjuvants
conventional
treatment
strategies.
Therefore,
this
review
focuses
on
antitumor
effects
curcumin,
resveratrol,
polydatin
cancer.
According
main
databases,
only
vitro
preclinical
studies
with
solid
scientific
backgrounds
reports
protective
were
included.
Curcumin,
antioxidant,
anti‐inflammatory,
effects;
indeed,
they
improve
efficacy;
reduce
chemoresistance,
angiogenesis,
tumor
growth;
induce
apoptosis,
autophagy,
cell
cycle
arrest
through
multiple
molecular
pathways,
including
suppression
epithelial–mesenchymal
transition
(EMT),
NF‐κB,
PI3K/Akt/mTOR,
c‐Jun
N‐terminal
kinase
(JNK),
MAPK,
ERK1/2,
STAT
signaling
pathways;
inhibition
cyclins
matrix
metalloproteinase
(MMP)‐2
MMP‐9;
activation
p53
microtubule‐associated
protein
light
chain
3
(LC3).
European Journal of Pharmaceutics and Biopharmaceutics,
Journal Year:
2024,
Volume and Issue:
200, P. 114343 - 114343
Published: May 25, 2024
Responsive
and
adaptive
soft-matter
systems
represent
an
advanced
category
of
materials
with
potential
applications
in
drug
delivery.
Among
these,
liquid
crystals
(LCs)
emerge
as
multifunctional
anisotropic
scaffolds
capable
reacting
to
temperature,
light,
electric
or
magnetic
fields.
Specifically,
the
ordering
physical
characteristics
thermotropic
LCs
are
primarily
contingent
on
temperature
external
stimulus.
This
comprehensive
review
aims
bridge
a
notable
gap
biomedical
application
mesogens
by
exclusively
focusing
Anticipated
inspire
diverse
ideas,
intends
facilitate
elegant
exploitation
controllable
temperature-induced
enhance
permeation.
Here,
we
delineate
recent
advancements
thermally-driven
substantial
emphasis
LC
monomer
mixtures,
elastomers,
polymers,
microcapsules
membranes.
Moreover,
special
is
placed
biocompatibility
toxicity
foremost
prerequisite
for
their
healthcare.
Given
promising
prospect
formulations
clinical
context,
section
devoted
skin
The
covers
content
from
multiple
disciplines,
targeting
researchers
interested
innovative
strategies
It
also
appeals
those
enthusiastic
about
firsthand
exploration
feasible
LCs.
To
best
our
knowledge,
this
marks
first
addressing
tunable
