Beilstein Journal of Nanotechnology,
Journal Year:
2024,
Volume and Issue:
15, P. 569 - 579
Published: May 22, 2024
Hepatocellular
carcinoma
(HCC)
is
the
sixth
most
common
malignant
tumor
and
third
leading
cause
of
cancer
death
worldwide.
Most
patients
are
diagnosed
at
an
advanced
stage,
systemic
chemotherapy
preferred
treatment
modality
for
HCC.
Curcumin
(CUR)
a
polyphenolic
antineoplastic
drug
with
low
toxicity
obtained
from
plants.
However,
its
bioavailability
poor
solubility
limit
functionality.
In
this
study,
radiofrequency-
(RF)
enhanced
responsive
nanoflowers
(NFs),
containing
superparamagnetic
ferric
oxide
nanoclusters
(Fe
3
O
4
NCs),
–
CUR
layer,
MnO
2
(CUR-Fe@MnO
NFs),
were
verified
to
have
thermal
therapeutic
effect.
Transmission
electron
microscopy
was
used
characterize
CUR-Fe@MnO
NFs,
which
appeared
flower-like
size
96.27
nm.
The
in
vitro
experimental
data
showed
that
RF
degradation
NFs
release
Mn
2+
CUR.
cytotoxicity
test
results
indicated
after
heating,
significantly
suppressed
HCC
cell
proliferation.
Moreover,
effective
T
1
/
contrast
agents
molecular
magnetic
resonance
imaging
due
Fe
NCs.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 114 - 114
Published: Jan. 15, 2025
Curcumin,
a
bioactive
compound
derived
from
the
rhizome
of
Curcuma
longa
L.,
has
garnered
significant
attention
for
its
potent
anticancer
properties.
Despite
promising
therapeutic
potential,
poor
bioavailability,
rapid
metabolism,
and
low
water
solubility
hinder
curcumin’s
clinical
application.
Nanotechnology
offers
viable
solution
to
these
challenges
by
enabling
development
curcumin-based
nanoparticles
(CNPs)
that
enhance
bioavailability
efficacy.
This
review
provides
comprehensive
overview
recent
advancements
in
design
synthesis
CNPs
cancer
therapy.
We
discuss
various
NP
formulations,
including
polymeric,
lipid-based,
inorganic
nanoparticles,
highlighting
their
role
improving
pharmacokinetic
pharmacodynamic
profiles.
The
mechanisms
which
exert
effects,
such
as
inducing
apoptosis,
inhibiting
cell
proliferation,
modulating
signaling
pathways,
are
explored
details.
Furthermore,
we
examine
preclinical
studies
have
demonstrated
efficacy
treating
different
types
tumors,
breast,
colorectal,
pancreatic
cancers.
Finally,
addresses
current
future
perspectives
translation
CNPs,
emphasizing
need
further
research
optimize
targeted
delivery
outcomes.
By
synthesizing
latest
research,
this
underscores
potential
avenue
advancing
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(7), P. 2131 - 2141
Published: Jan. 16, 2024
Ischemia/reperfusion
(IR)-induced
acute
lung
injury
(ALI)
has
a
high
mortality
rate.
Reactive
oxygen
species
(ROS)
play
crucial
role
in
causing
cellular
damage
and
death
IR-induced
ALI.
In
this
work,
we
developed
biomimetic
lung-targeting
nanoparticle
(PC@MB)
as
an
antioxidative
protector
for
treating
PC@MBs
showed
excellent
ROS
scavenging
Nrf2
activation
properties,
along
with
function
through
autologous
cell
membrane
coating.
The
exhibited
impressive
pulmonary
protective
via
redox
homeostasis
recovery
heme
oxygenase-1
activation.
could
maintain
viability
by
effectively
the
intracellular
restoring
equilibrium
lesion.
IR
mouse
model,
preferentially
accumulated
distinctly
repaired
pneumonic
damage.
Our
strategy
potential
to
offer
promising
therapeutic
paradigm
ALI
incorporation
of
different
mechanisms.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 8, 2024
Applying
artificial
intelligence
(AI)
to
nanomedicine
has
greatly
increased
the
production
of
specially
engineered
nanoscale
materials
for
tailored
medicine,
marking
a
significant
advancement
in
healthcare.
With
use
AI,
researchers
can
search
through
massive
databases
and
find
nano-properties
that
support
range
therapeutic
objectives,
eventually
producing
safer,
customized
nanomaterials.
AI
analyzes
patient
data,
including
clinical
genetic
information,
predict
results
individualized
care
makes
recommendations
therapy
improvement.
Furthermore,
logically
creates
nanocarriers
give
precise
controlled
drug
release
patterns
optimize
advantages
minimize
undesirable
side
effects.
Even
though
lot
potential
nanomedicine,
there
are
still
issues
data
integration
techniques,
moral
dilemmas,
requirement
governmental
backing.
Future
developments
tools
multidisciplinary
cooperation
between
scientists
with
expertise
biological
sciences
nanoengineering
essential
nanomedicine.
Together,
these
disciplines
propel
advancements
precision
contributing
ultimate
objective—a
future
which
combine
provide
really
The
authors
this
editorial
encourage
call
on
scientists,
physicians,
legislators
acknowledge
its
transform
treatment.
Asian Journal of Pharmaceutical and Clinical Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 8 - 26
Published: Feb. 7, 2025
Hepatocellular
carcinoma
(HCC)
represents
a
significant
threat
to
global
health
and
is
responsible
for
mortality
rates
worldwide.
Conventional
treatment
options
such
as
surgery
chemotherapy
have
inherent
limitations.
In
order
remedy
these
deficits,
the
development
of
novel
therapeutic
strategies
essential.
Nanomedicines
shown
promise
in
HCC
they
offer
improved
stability,
controlled
release,
increased
drug
loading
capacity.
This
review
explores
application
nanoconstructs
treatment,
including
active
passive
targeting
strategies.
addition,
liver
cell
approaches,
moieties,
conjugation
chemistry
surface
functionalization
are
investigated.
A
compact
overview
various
approaches
also
given.
Journal of Inflammation Research,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 1735 - 1763
Published: March 1, 2024
Gouty
arthritis
(GA)
is
an
immune-mediated
disorder
characterized
by
severe
inflammation
due
to
the
deposition
of
monosodium
urate
(MSU)
crystals
in
joints.
The
pathophysiological
mechanisms
GA
are
not
yet
fully
understood,
and
therefore,
identification
effective
therapeutic
targets
paramount
importance.
Neutrophil
extracellular
traps
(NETs),
intricate
structure
DNA
scaffold,
encompassing
myeloperoxidase,
histones,
elastases
-
have
gained
significant
attention
as
a
prospective
target
for
gouty
arthritis,
their
innate
antimicrobial
immunomodulatory
properties.
Hence,
exploring
potential
NETs
remains
enticing
avenue
further
investigation.
During
process
formation
triggers
release
inflammatory
cytokines,
thereby
contributing
response,
while
MSU
cytokines
sequestered
degraded
aggregation
NETs.
Here,
we
provide
concise
summary
processes
underlying
initiation
resolution
mediated
Furthermore,
this
review
presents
overview
current
pharmacological
approaches
treating
summarizes
natural
synthetic
product-based
inhibitors
that
NET
novel
options,
alongside
elucidating
intrinsic
challenges
these
research.
Lastly,
limitations
HL-60
cell
suitable
substitute
neutrophils
research
summarized
discussed.
Series
recommendations
provided,
strategically
oriented
towards
guiding
future
investigations
effectively
address
concerns.
These
findings
will
contribute
enhanced
comprehension
interplay
between
GA,
facilitating
proposition
innovative
strategies
management
GA.
European Journal of Pharmaceutics and Biopharmaceutics,
Journal Year:
2024,
Volume and Issue:
200, P. 114343 - 114343
Published: May 25, 2024
Responsive
and
adaptive
soft-matter
systems
represent
an
advanced
category
of
materials
with
potential
applications
in
drug
delivery.
Among
these,
liquid
crystals
(LCs)
emerge
as
multifunctional
anisotropic
scaffolds
capable
reacting
to
temperature,
light,
electric
or
magnetic
fields.
Specifically,
the
ordering
physical
characteristics
thermotropic
LCs
are
primarily
contingent
on
temperature
external
stimulus.
This
comprehensive
review
aims
bridge
a
notable
gap
biomedical
application
mesogens
by
exclusively
focusing
Anticipated
inspire
diverse
ideas,
intends
facilitate
elegant
exploitation
controllable
temperature-induced
enhance
permeation.
Here,
we
delineate
recent
advancements
thermally-driven
substantial
emphasis
LC
monomer
mixtures,
elastomers,
polymers,
microcapsules
membranes.
Moreover,
special
is
placed
biocompatibility
toxicity
foremost
prerequisite
for
their
healthcare.
Given
promising
prospect
formulations
clinical
context,
section
devoted
skin
The
covers
content
from
multiple
disciplines,
targeting
researchers
interested
innovative
strategies
It
also
appeals
those
enthusiastic
about
firsthand
exploration
feasible
LCs.
To
best
our
knowledge,
this
marks
first
addressing
tunable
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
177, P. 117118 - 117118
Published: July 14, 2024
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
prevalent
malignant
tumors
in
contemporary
era,
representing
a
significant
global
health
concern.
Early
HCC
patients
have
mild
symptoms
or
are
asymptomatic,
which
promotes
onset
and
progression
disease.
Moreover,
advanced
insensitive
to
chemotherapy,
making
traditional
clinical
treatment
unable
block
cancer
development.
Sorafenib
(SFB)
first-line
targeted
drug
for
with
anti-angiogenesis
anti-tumor
cell
proliferation
effects.
However,
efficacy
SFB
constrained
by
its
off-target
distribution,
rapid
metabolism,
multi-drug
resistance.
In
recent
years,
nanoparticles
based
on
variety
materials
been
demonstrated
enhance
targeting
therapeutic
against
HCC.
Concurrently,
advent
joint
delivery
systems
has
furnished
crucial
empirical
evidence
reversing
This
review
will
summarize
application
nanotechnology
field
over
past
five
years.
It
focus
research
progress
combined
multiple
modalities
treatment.
